Search results for "Nonsense"
showing 10 items of 140 documents
Sentir lo indecible. Sentido, sin sentido y carencia de sentido en el Tractatus de Wittgenstein
2008
Este artículo analiza la concepción wittgensteiniana del sin sentido y, contra las interpretaciones resolutas, defiende que, bajo la influencia quizás de Mauthner y Weininger, el autor del Tractutus consideró los sin sentidos ontológicos y éticos correctos como cercanos a las proposiciones tautológicas carentes de sentido. This article analyses Wittgenstein�s conception of nonsense and, against resolute interpretations, defends that, perhaps influenced by Mauthner and Weininger, the Tractatus author conceived corrects ontological and ethical nonsenses like nearly to tautological senseless.
Absurdist humor
2014
International audience
Eccentricity in Mervyn Peake’s work
2013
International audience; Ce chapitre analyse l’un des motifs principaux de l’œuvre de Mervyn Peake: l’excentricité et ses modes d’expression textuelle et picturale dans Letters from a Lost Uncle (1948) et Figures of Speech (1954), au sein de l’intertexte formé par les biographies d’excentriques et le nonsense.
Genome-wide chromosomal association of Upf1 is linked to Pol II transcription in Schizosaccharomyces pombe
2021
AbstractAlthough the RNA helicase Upf1 has hitherto been examined mostly in relation to its cytoplasmic role in nonsense mediated mRNA decay (NMD), here we report high-throughput ChIP data indicating genome-wide association of Upf1 with active genes in Schizosaccharomyces pombe. This association is RNase sensitive and it correlates with Pol II transcription and mRNA expression levels. While changes in Pol II occupancy were detected at only some genes in a Upf1-deficient (upf1Δ) strain, there is an increased Ser2 Pol II signal at all highly transcribed genes examined by ChIP-qPCR. Furthermore, upf1Δ cells are hypersensitive to the transcription elongation inhibitor 6-azauracil and display Po…
Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons
2020
Cystic fibrosis (CF) is caused by mutations in the gene encoding the transmembrane conductance regulator (CFTR) protein. Some CF patients are compound heterozygous or homozygous for nonsense mutations in the CFTR gene. This implies the presence in the transcript of premature termination codons (PTCs) responsible for a truncated CFTR protein and a more severe form of the disease. Aminoglycoside and PTC124 derivatives have been used for the read-through of PTCs to restore the full-length CFTR protein. However, in a precision medicine framework, the CRISPR/dCas13b-based molecular tool &ldquo
Early literacy skills in Latvian preschool children with specific language impairment
2014
The present study explores differences in early literacy skills of Latvian preschool children with Specific Language Impairment (SLI) compared to children from general population. The participants were 21 children with diagnosis of Specific developmental disorders of speech and language (F80; ICD-10) and 21 children as matched control group (in each group: mean age=79 months, 88% boys). Both samples were selected from the adaptation and standardization study of Dynamic Indicators of Basic Early Literacy Skills (DIBELS Next) in Latvia (Good & Kaminski et al., 2011; Latvian version, Rascevska et al., 2013a). The results show significant differences between two groups in DIBELS Next composite …
Le dégoût pour la raison face à la réalité sociale du XXe siècle dans des écrits choisis de Marguerite Duras
2020
One of the important problems raised in the works by Marguerite Duras is a specific opposition to rationalism, understood as the loss of meaning and absurdity of human existence in the face of the tragedy of World War Two. In this way, the author presents her attitude to Nazi barbarism, and in a broader context to the history of mankind. Her texts − exposing the writer’s doubts and obsessions − express the lack of logic of the world, the painful awareness of the inevitability of misfortune, existential emptiness, and the powerlessness of a man towards his own impotence. By rejecting “material life”, Duras’s work resounds with the contestation of rationalism illustrating the paradoxes of the…
Molecular Approaches Fighting Nonsense
2021
Nonsense mutations are the result of single nucleotide substitutions in the DNA that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of the mRNA [...]
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense
Pasila satiirin, koomisen ja absurdin rajoilla
2016
Pasila (Filmiteollisuus Fine Mediastation Oy tuotantokaudet 1.–2. vuosina 2007–2009 ja Yellow Film & TV tuotantokaudet 3.–6. vuosina 2011–2013) päättyi kuuden tuotantokauden jälkeen vuonna 2013 suosionsa huipulle. Sarjan nauttimasta innostuksesta kertoo jo se, että ohjaaja-käsikirjoittaja Atte Järvisen lopetuspäätöksestä huolimatta, YLE jatkoi sarjaa uuden tekijätiimin voimalla Pasila 2.5 - The Spin-off -version muodossa. Vaikka varsinaisen animaation viimeisestä kaudesta on ehtinyt kulua jo useampi vuosi, on Pasilaa tarkasteltu tutkimuksissa lähinnä animaatioteknisistä lähtökohdista. Sarjalla on kuitenkin annettavaa myös kirjallisuudentutkimukselle. Tässä kirjallisuuden maisterintutkielmas…