Search results for "Normal"

showing 10 items of 2571 documents

Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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On the relationships between tectonics and volcanism in the offshore capo vaticano, se tyrrhenian sea, during the plio-pleistocene.

2014

High-resolution bathymetry and a grid of single-channel reflection seismic profiles (Sparker and Chirp) were recently recorded in a sector of the upper slope of Capo Vaticano (CV) promontory (Tyrrhenian coast, W Calabria) where forward and inverse modeling of previously acquired aeromagnetic data highlight the presence of a WNW©\ESE elongated, 20 km long and 3¨C5 km wide, magnetized body extending from sea floor to about 3 km below sea level. Magnetic properties of this body are consistent with those of the medium to highly evolved volcanic rocks of the Aeolian Arc (De Ritis et al., 2010). Forthwith offshore promontory, the bathymetry highlights a complex-shape seamount that develops along …

Settore GEO/02 - Geologia Stratigrafica E SedimentologicaSettore GEO/03 - Geologia StrutturaleSub-marine volcano normal faults Calabria
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Evolved factor method for service life prediction of building components

2013

Key issues in the production process associated with construction are the implementation of quality and sustainability principles. Indeed, it is increasingly important in the maintenance of quality levels provided by materials, components and building structures, especially after the recent Regulation (EU) No. 305/2011. This document introduced the seventh requirement for the sustainable use of natural resources, guaranteeing the durability of construction products, thus being planned. The international standard for the assessment of durability of building materials and components is the ISO 15686 - Buildings and constructed assets - Service life planning, providing the definition of the Re…

Settore ICAR/11 - Produzione EdiliziaFactor method durability service life log-normal function probability distribution function
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Palmprint principal lines extraction

2014

The palmprint recognition has become a focus in biological recognition and image processing fields. In this process, the features extraction (with particular attention to palmprint principal line extraction) is especially important. Although a lot of work has been reported, the representation of palmprint is still an open issue. In this paper we propose a simple, efficient, and accurate palmprint principal lines extraction method. Our approach consists of six simple steps: normalization, median filtering, average filters along four prefixed directions, grayscale bottom-hat filtering, combination of bottom-hat filtering, binarization and post processing. The contribution of our work is a new…

Settore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniEngineeringGround truthBiometricsbusiness.industryFeature extractionsegmentationNormalization (image processing)Palm line extractionImage processingPattern recognitionGrayscalePalmprint; Palm line extraction; segmentation; biometricbiometricMedian filterComputer visionSegmentationArtificial intelligencePalmprintbusiness
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Sentence Induced Transformations in Conceptual Spaces

2008

The proposed work illustrates how "primitive concepts" can be automatically induced from a text corpus. The primitive concepts are identified by the orthonormal axis of a "conceptual" space induced by a methodology inspired to the latent semantic analysis approach. The methodology represents a natural language sentence by means of a set of rotations of an orthonormal basis in the "conceptual"space. The rotations, triggered by the sequence of words composing the sentence and realized by means of geometric algebra rotors, allow to highlight "conceptual" relations that can arise among the primitive concepts.

Settore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniSequenceComputer sciencebusiness.industryLatent semantic analysisChatbots conceptual spaces LSA semantic computingWord processingData_MISCELLANEOUScomputer.software_genreGeometric algebraSemantic role labelingOrthonormal basisArtificial intelligencebusinesscomputerNatural languageNatural language processingSentence
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Normalised compression distance and evolutionary distance of genomic sequences: comparison of clustering results

2009

Genomic sequences are usually compared using evolutionary distance, a procedure that implies the alignment of the sequences. Alignment of long sequences is a time consuming procedure and the obtained dissimilarity results is not a metric. Recently, the normalised compression distance was introduced as a method to calculate the distance between two generic digital objects and it seems a suitable way to compare genomic strings. In this paper, the clustering and the non-linear mapping obtained using the evolutionary distance and the compression distance are compared, in order to understand if the two distances sets are similar.

Settore ING-INF/05 - Sistemi Di Elaborazione Delle Informazionibusiness.industryCompression (functional analysis)Metric (mathematics)Normalized compression distanceuniversal similarity metric USM clustering DNA sequences normalised compression distance evolutionary distance genomic sequences nonlinear mapping bioinformaticsPattern recognitionArtificial intelligenceCluster analysisbusinessDistance matrices in phylogenyMathematics
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Indipendenza, dipendenza, interdipendenza in una società di singoli

2023

Questo testo è dedicato alla distinzione tra individualismo e singolarismo. Quest'ultimo richiede una profonda revisione del modo di considerare le relazioni sociali fondamentali

Settore IUS/20 - Filosofia Del DirittoIndividualism Singularity Normal
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Rules and norms: two kinds of normative behaviour:

2016

Celano’s notion of a “pre-convention” is grounded in the opposition between two allegedly different kinds of normative behaviour: observing a “rule” and conforming to a “norm”. This opposition plays a central role in Celano’s paper, and marks a crucial point in his intellectual trajectory. Nevertheless, it remains largely implicit. In this paper, I try to make it fully explicit, giving a more precise characterisation of both kinds of normative behaviour. I also focus on the importance of distinguishing between them, express some conjectures (or wishes) regarding Celano’s future research, and propose a (marginal) criticism.

Settore IUS/20 - Filosofia Del DirittoOpposition (politics)NormativeCriticismRule followingNorm (social)rule-following fast and slow mental processes rules and habits norms and normalityPsychologyLawCrucial pointSocial psychologyEpistemology
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Overestimation of numerical distances in the left space

2004

Normal subjects presented with a middle number and two left- and right-sided outer numbers overestimate the numerical distance between the middle number and that positioned at its left side. Repetitive transcranial magnetic stimulation (rTMS) of the right posterior parietal cortex specifically counteracts this bias, suggesting that the mental representation of space defined by numbers is shifted toward the left side depending on a greater activity of the right hemisphere.

Settore M-PSI/02 - Psicobiologia E Psicologia Fisiologicabiparietal distance female human human experiment left hemisphere male normal human parietal lobe priority journal right hemisphere transcranial magnetic stimulation
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A NOTE ON THE CATEGORICAL NOTIONS OF NORMAL SUBOBJECT AND OF EQUIVALENCE CLASS

2021

In a non-pointed category E, a subobject which is normal to an equivalence relation is not necessarily an equivalence class. We elaborate this categorical distinction, with a special attention to the Mal'tsev context. Moreover, we introduce the notion of fibrant equipment, and we use it to establish some conditions ensuring the uniqueness of an equivalence relation to which a given subobject is normal, and to give a description of such a relation.

Settore MAT/02 - AlgebraMal'tsev and protomodular categoriesunitalnormal subobjectequivalence classconnected pair of equivalence relations
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