Search results for "Normal"

showing 10 items of 2571 documents

Predicted and actual fetal weight throughout the last trimester.

1997

The aim of our study was to obtain, in normal pregnancies, references values of predicted and actual fetal weight for both male and female fetuses and for fetuses born to nulliparous and multiparous women between weeks 28 and 41 of gestation. Predicted fetal weight curves represented calculations of weight in the third trimester based on weight data obtained during the second trimester. These curves were obtained from 134 ultrasonograms obtained between weeks 20 and 27. Actual fetal weight curves represented the values calculated from third trimester measurements and were based on 374 ultrasonograms obtained between weeks 28 and 41. For predicted fetal weight minor differences were found be…

AdultMalemedicine.medical_specialtyPregnancy Trimester ThirdGestational AgeThird trimesterUltrasonography PrenatalFetusPredictive Value of TestsPregnancySecond trimestermedicineHumansRadiology Nuclear Medicine and imagingGynecologyFetusRadiological and Ultrasound TechnologyObstetricsbusiness.industryBody WeightFetal weightParityembryonic structuresNormal growthGestationFemaleParity (mathematics)businessJournal of Ultrasound in Medicine
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Analysis of thiamine transporter genes in sporadic beriberi

2014

Abstract Objective Thiamine or vitamin B 1 deficiency diminishes thiamine-dependent enzymatic activity, alters mitochondrial function, impairs oxidative metabolism, and causes selective neuronal death. We analyzed for the first time, the role of all known mutations within three specific thiamine carrier genes, SLC19 A2, SLC19 A3 , and SLC25 A19 , in a patient with atrophic beriberi, a multiorgan nutritional disease caused by thiamine deficiency. Methods A 44-year-old male alcoholic patient from Morocco developed massive bilateral leg edema, a subacute sensorimotor neuropathy, and incontinence. Despite normal vitamin B 1 serum levels, his clinical picture was rapidly reverted by high-dose in…

AdultMalemedicine.medical_specialtySLC19 A- SLC25 A19SLC19 AEndocrinology Diabetes and MetabolismGene mutationBeriberimedicine.disease_causeMitochondrial Membrane Transport Proteinslaw.inventionBeriberilawInternal medicineGenotypemedicineThiamine transporterObjective: Thiamine or vitamin B1 deficiency diminishes thiamine-dependent enzymatic activity alters mitochondrial function impairs oxidative metabolism and causes selective neuronal death. We analyzed for the first time the role of all known mutations within three specific thiamine carrier genes SLC19 A2 SLC19 A3 and SLC25 A19 in a patient with atrophic beriberi a multiorgan nutritional disease caused by thiamine deficiency. Methods: A 44-year-old male alcoholic patient from Morocco developed massive bilateral leg edema a subacute sensorimotor neuropathy and incontinence. Despite normal vitamin B1 serum levels his clinical picture was rapidly reverted by high-dose intramuscular thiamine treatment suggesting a possible genetic resistance. We used polymerase chain reaction followed by amplicon sequencing to study all the known thiamine-related gene mutations identified within the Human Gene Mutation Database. Results: Thirty-seven mutations were tested: 29 in SLC19 A2 6 in SLC19 A3 and 2 in SLC25 A19. Mutational analyses showed a wild-type genotype for all sequences investigated. Conclusion: This is the first genetic study in beriberi disease. We did not detect any known mutation in any of the three genes in a sporadic dry beriberi patient. We cannot exclude a role for other known or unknown mutations in the same genes or in other thiamine-associated genes in the occurrence of this nutritional neuropathy.HumansThiamineGenePolymerase chain reactionGeneticsMutationNutrition and DieteticsbiologyMembrane Transport ProteinsThiamine Deficiencymedicine.diseaseAlcoholismEndocrinologyMutationbiology.proteinThiamineMutations
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Training volume, androgen use and serum creatine kinase activity.

1989

Serum creatine kinase (CK) activities were investigated in elite male strength athletes (n = 20) during normal weight training and bodybuilding training (one training session per day), during high volume strength training (two sessions per day) and during strength training (one session per day) with the use of high dose synthetic androgens (five athletes in each subgroup). The findings demonstrated that the increase in serum CK was highest in the subgroup using androgens. These results suggest that strength training with the use of androgenic steroids leads to higher serum CK activities than normal strength training.

AdultMalemedicine.medical_specialtySynthetic androgensStrength trainingmedicine.drug_classeducationPhysical Therapy Sports Therapy and RehabilitationAnabolic AgentsInternal medicineMedicineHumansOrthopedics and Sports MedicineCreatine KinaseExercisePhysical Education and Trainingbiologybusiness.industryAthletesAndrogenic steroidsGeneral MedicineAndrogenbiology.organism_classificationEndocrinologyNormal weightbiology.proteinSerum creatine kinaseCreatine kinasebusinessResearch Article
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Results of the performance verification of the CoaguChek XS system.

2008

Abstract Background This is the first paper reporting a performance verification study of a point-of-care (POC) monitor for prothrombin time (PT) testing according to the requirements given in chapter 8 of the International Organization for Standardization (ISO) 17593:2007 standard “Clinical laboratory testing and in vitro medical devices — Requirements for in vitro monitoring systems for self-testing of oral anticoagulant therapy”. The monitor under investigation was the new CoaguChek XS system which is designed for use in patient self testing. Its detection principle is based on the amperometric measurement of the thrombin activity generated by starting the coagulation cascade using a rec…

AdultMalemedicine.medical_specialtyTime FactorsCoefficient of variationPoint-of-Care SystemsThromboplastinYoung AdultCoagulation cascadeAcceptance testingReference ValuesmedicineHumansIn patientInternational Normalized RatioBlood testingBlood CoagulationOral anticoagulationAgedReagent StripsProthrombin timeAged 80 and overmedicine.diagnostic_testbusiness.industryAnticoagulantsHematologyMiddle AgedRecombinant ProteinsSurgerySelf CareOral anticoagulantProthrombin TimeFemaleDrug MonitoringbusinessBiomedical engineeringThrombosis research
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Evaluation of urodynamic studies by computer

1978

In an attempt to simplify urodynamic evaluation, the data obtained from cystometry, urethral profile and flowmetry were analysed using the ICS recommendations for standardization and terminology. All studies were compiled from check lists feasible for computation. The aim was to establish standards and "typical" changes for the normal bladder and pathological states to enable automatic readout of computed data. The results did, in fact, show "typical" changes but failed to establish standard measurements suitable for completely computed diagnoses.

AdultMalemedicine.medical_specialtyUrethral ObstructionAdolescentStandardizationManometryUrologyUrinary BladderUrodynamic studiesTerminologyUrethraHydrostatic PressuremedicineHumansMedical physicsDiagnosis Computer-AssistedUrinary Bladder NeurogenicMedical diagnosisChildAgedmedicine.diagnostic_testElectromyographybusiness.industryInfantCystometryMiddle AgedSurgeryUrinary IncontinenceChild PreschoolNormal bladderFemalebusinessUrological Research
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Comparison of tactile sensitivity measured with a new digital esthesiometer (Beam Test) relative to Semmes–Weinstein monofilament analog esthesiometer

2019

The assessment of tactile sensitivity uses many tests, of which monofilaments are considered the best. The aim of this study was to develop a tactile sensitivity test, similar to the monofilament test, which eliminates the error risk related to manipulations by the observer, and to establish a correspondence scale. We studied 29 healthy subjects (18 women and 11 men) with a mean age of 27.8 years. The Semmes-Weinstein monofilament (SWM) analog esthesiometer and a digital beam esthesiometer (DBE) were used. We evaluated the tactile sensitivity threshold on the fingertip of each subject's dominant index using the SWM and the DBE. The DBE test consisted of applying the index against the tip of…

AdultMalemedicine.medical_specialty[SHS.INFO]Humanities and Social Sciences/Library and information sciences030230 surgeryAudiology[SHS]Humanities and Social SciencesFingers03 medical and health sciences0302 clinical medicineNormal sensationmedicineHumansOrthopedics and Sports MedicineComputingMilieux_MISCELLANEOUSMathematicsNeurologic Examination030222 orthopedicsRehabilitationHealthy subjectsMean ageHealthy Volunteers3. Good healthTest (assessment)Sensitivity testTouchSensory ThresholdsSurgeryFemaleEsthesiometerSensitivity (electronics)Beam (structure)
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Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study

2020

Abstract Aims  To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages. Methods and results  A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were −15.0% in men and −15.6% in women for epicardial strain, −16.8% …

AdultMalemedicine.medical_specialtyadult echocardiographydeformation imagingHeart Ventricles030204 cardiovascular system & hematologyVentricular Function LeftReference values2D echocardiography03 medical and health sciences0302 clinical medicine[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicinereference values.Healthy volunteersmedicineHumansRadiology Nuclear Medicine and imaging030212 general & internal medicineEndocardiumNormal rangeStrain (chemistry)business.industryMyocardiumHealthy subjectsreference valueMean ageGeneral MedicineMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREMiddle AgedApex (geometry)EchocardiographyCardiology[SDV.IB]Life Sciences [q-bio]/BioengineeringFemalebusinessLarge groupCardiology and Cardiovascular MedicineEndocardiumHuman
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Human papillomavirus is commonly present in psoriatic skin and normal skin samples from healthy subjects

2007

Letter to editor No abstract

AdultMalemedicine.medical_specialtybusiness.industryPapillomavirus InfectionsHealthy subjectsDermatologyMiddle AgedBiochemistryDermatologyPsoriatic skinPrevalencemedicineHumansPsoriasisFemaleHuman papillomavirusNormal skinbusinessMolecular BiologySkinJournal of Dermatological Science
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Effects of enzyme replacement therapy on growth in patients with mucopolysaccharidosis type II

2010

Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is an X-linked, recessive, lysosomal storage disorder caused by deficiency of iduronate-2-sulfatase. It has multisystemic involvement, with manifestations in the brain, upper respiratory tract, heart, abdomen, joints and bones. Bone involvement leads to decreased growth velocity and short stature in nearly all patients. A therapeutic option for patients with MPS II is enzyme replacement therapy (ERT) with idursulfase (Elaprase®). We compared annual growth rates before and during ERT in 18 patients from Mainz, Germany, and Manchester, UK. Group 1 included nine patients who started ERT before 10 years of age; group 2 contained nine patie…

AdultMalemedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesAdolescentIdursulfaseIduronate SulfatasePlaceboShort staturePlacebosYoung AdultChild DevelopmentClinical Trials Phase II as TopicmedicineGeneticsHumansGenetics(clinical)Enzyme Replacement TherapyMucopolysaccharidosis type IIYoung adultGrowth ChartsChildGenetics (clinical)Mucopolysaccharidosis IIbusiness.industrynutritional and metabolic diseasesHunter syndromeEnzyme replacement therapymedicine.diseaseBody HeightSurgerymedicine.anatomical_structureClinical Trials Phase III as TopicAbdomenOriginal Articlemedicine.symptombusinessmedicine.drugJournal of Inherited Metabolic Disease
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Clinical experience and perinatal outcome of blastocyst transfer after coculture of human embryos with human endometrial epithelial cells: a 5-year f…

2003

Abstract Objective To evaluate the reproductive and neonatal outcome of blastocyst transfer after coculture with human endometrial epithelial cells in IVF and oocyte donation. Design Retrospective study. Setting Private assisted reproductive center. Patient(s) Two hundred sixty women undergoing IVF and 469 oocyte recipients. Intervention(s) IVF or intracytoplasmic sperm injection (ICSI) and transfer of at least one blastocyst after coculture with human endometrial epithelial cells. Main outcome measure(s) Blastocyst formation rate, implantation and pregnancy rates, neonatal outcome, and congenital birth defects. Results Among patients who had transfer with their own oocytes, 1,193 of 2,349 …

AdultMalemedicine.medical_specialtymedicine.medical_treatmentBiologyEndometriumIntracytoplasmic sperm injectionCongenital AbnormalitiesEndometriumPregnancyRisk FactorsmedicineHumansBlastocystEmbryo ImplantationSex Ratioreproductive and urinary physiologyRetrospective StudiesGynecologyPregnancyurogenital systemBlastocyst TransferPregnancy OutcomeObstetrics and GynecologyEmbryo cultureEpithelial Cellsmedicine.diseaseEmbryo TransferEmbryo MammalianEmbryo transferCoculture Techniquesmedicine.anatomical_structureReproductive Medicineembryonic structuresGestationFemalePregnancy MultipleFollow-Up StudiesFertility and sterility
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