Search results for "Normal"

The interrelationship of religion and magic in the experience of Latvians in Timofeyevka, Siberia

2014

Analysis of a slow–fast system near a cusp singularity

2016

This paper studies a slow fast system whose principal characteristic is that the slow manifold is given by the critical set of the cusp catastrophe. Our analysis consists of two main parts: first, we recall a formal normal form suitable for systems as the one studied here; afterwards, taking advantage of this normal form, we investigate the transition near the cusp singularity by means of the blow up technique. Our contribution relies heavily in the usage of normal form theory, allowing us to refine previous results. (C) 2015 Elsevier Inc. All rights reserved.

Nuclear Translocation of Mismatch Repair Proteins MSH2 and MSH6 as a Response of Cells to Alkylating Agents

2000

Mammalian mismatch repair has been implicated in mismatch correction, the prevention of mutagenesis and cancer, and the induction of genotoxicity and apoptosis. Here, we show that treatment of cells specifically with agents inducing O(6)-methylguanine in DNA, such as N-methyl-N'-nitro-N-nitrosoguanidine and N-methyl-N-nitrosourea, elevates the level of MSH2 and MSH6 and increases GT mismatch binding activity in the nucleus. This inducible response occurs immediately after alkylation, is long-lasting and dose-dependent, and results from translocation of the preformed MutSalpha complex (composed of MSH2 and MSH6) from the cytoplasm into the nucleus. It is not caused by an increase in MSH2 gen…

Schools without measurements : towards a pedagogy of recognition

2017

Since the OECD launched the Program for International Student Assessment (PISA) in 2000, education measurements have mainly been concerned with recording and issuing results in terms of school success or failure based on items aimed at measuring academic achievement. A major consequence of this obsession with quantifiable results, which stems from a sort of statistical monoculture, has been a shift of our attention away from the seminal fact that, indeed, educational disparities are directly linked to social inequalities. Besides, the application of accountability criteria within systems of education tends to hide the increasing deregulation of the former. Contrary to its seeming appearance…

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a target in LKB1 Mutant Lung Cancer

2013

Abstract The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism. In non–small cell lung carcinoma, LKB1 is somatically inactivated in 25% to 30% of cases, often concurrently with activating KRAS mutations. Here, we used an integrative approach to define novel therapeutic targets in KRAS-driven LKB1-mutant lung cancers. High-throughput RNA interference screens in lung cancer cell lines from genetically engineered mouse models driven by activated KRAS with or without coincident Lkb1 deletion led to the identification of Dtymk, encoding deoxythymidylate kinase (DTYMK), which catalyzes dTTP biosynthesis, as synthetica…

In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi)

2020

Histone deacetylase inhibitors (HDACi) are already approved for the therapy of leukemias. Since they are also emerging candidate compounds for the treatment of non-malignant diseases, HDACi with a wide therapeutic window and low hazard potential are desirable. Here, we investigated a panel of 12 novel hydroxamic acid- and benzamide-type HDACi employing non-malignant V79 hamster cells as toxicology guideline-conform in vitro model. HDACi causing a &ge

Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus

2012

Coats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex. Consistent with the observation of shortened telomeres in an Arabidopsis CTC1 mutant and the phenotypic overlap of Coats plus with the telomeric maintenance disorders comprising dyskeratosis congenita, we observed shortened telomeres in three individuals with Coats plus and an increase in spontaneous γ 3H2AX-positive cells in cell lines derived from two affected individual…

Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition.

2014

ABSTRACT The Mycobacterium tuberculosis genome includes the large family of pe_pgrs genes, whose functions are unknown. Because of precedents in other pathogens in which gene families showing high sequence variation are involved in antigenic variation, a similar role has been proposed for the pe_pgrs genes. However, the impact of immune selection on pe_pgrs genes has not been examined. Here, we sequenced 27 pe_pgrs genes in 94 clinical strains from five phylogenetic lineages of the M. tuberculosis complex (MTBC). We found that pe_pgrs genes were overall more diverse than the remainder of the MTBC genome, but individual members of the family varied widely in their nucleotide diversity and in…

Analysis of the linkages between rainfall and land surface conditions in the West African monsoon through CMAP, ERS-WSC, and NOAA-AVHRR data

2005

International audience; The European Remote Sensing Wind Scatterometer (ERS-WSC) backscattering coefficient, NOAA Advanced Very High Resolution Radiometer (NOAA-AVHRR) Normalized Difference Vegetation Index (NDVI), and Climate Prediction Center Merged Analysis Precipitation ( CMAP) precipitation data sets are studied over the period August 1991 to December 2000 to document ( 1) the interannual and intra-annual evolutions of vegetation photosynthetic activity and soil-vegetation water content over West Africa and ( 2) their two-way links with precipitation. Over the Sahel, at interannual timescales the strongest relationships between vegetation, soil moisture, and precipitation are observed …

Parameter Rating by Diffusion Gradient

2014

Anomaly detection is a central task in high-dimensional data analysis. It can be performed by using dimensionality reduction methods to obtain a low-dimensional representation of the data, which reveals the geometry and the patterns that exist and govern it. Usually, anomaly detection methods classify high-dimensional vectors that represent data points as either normal or abnormal. Revealing the parameters (i.e., features) that cause detected abnormal behaviors is critical in many applications. However, this problem is not addressed by recent anomaly-detection methods and, specifically, by nonparametric methods, which are based on feature-free analysis of the data. In this chapter, we provi…