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showing 10 items of 2193 documents
Dynamic Antigen Presentation Patterns of Listeria monocytogenes-Derived CD8 T Cell Epitopes In Vivo
2001
Abstract Little information exists regarding the presentation of antigenic peptides in infected tissues. In this study the in vivo presentation of four different CD8 T cell epitopes of Listeria monocytogenes was monitored. Peptide presentation was measured by a new, highly sensitive, ex vivo Ag presentation assay that was based on the testing of freshly isolated cells from infected spleens with peptide-specific CD8 T cell lines in an IFN-γ-specific ELISPOT assay. Remarkably, the peptide presentation pattern of splenocytes and that of macrophages purified from spleens of L. monocytogenes-infected mice were different from those of in vitro infected macrophage-like cell lines. The in vivo Ag p…
Clostridium difficile Toxins Disrupt Epithelial Barrier Function by Altering Membrane Microdomain Localization of Tight Junction Proteins
2001
ABSTRACT The anaerobic bacterium Clostridium difficile is the etiologic agent of pseudomembranous colitis. C. difficile toxins TcdA and TcdB are UDP-glucosyltransferases that monoglucosylate and thereby inactivate the Rho family of GTPases (W. P. Ciesla, Jr., and D. A. Bobak, J. Biol. Chem. 273:16021–16026, 1998). We utilized purified reference toxins of C. difficile , TcdA-10463 (TcdA) and TcdB-10463 (TcdB), and a model intestinal epithelial cell line to characterize their influence on tight-junction (TJ) organization and hence to analyze the mechanisms by which they contribute to the enhanced paracellular permeability and disease pathophysiology of pseudomembranous colitis. The increase i…
A Dynamic Model of Ballasted Rail Track with Bituminous Sub-Ballast Layer
2012
AbstractThe bituminous sub-ballast layer within the ballasted rail track allows some mechanical and environmental advantages. An analytical model of a ballasted rail track with sub-ballast layer has been proposed by considering the rail as viscous-elastic continuous beam discretely supported, at four levels of elasticity.The model was used to compare the mechanical performance of both ballasted track with and without bituminous sub-ballast layer. The results confirmed that the bituminous sub-ballast layer reduces the dynamic forces on the ground and achieves the technical objectives as reduction of ground borne vibrations and increase of the design life of the rail track.
Optimization of the Mix-Design System for the Sub-ballast Railroad
2017
Bituminous sub-ballast is an alternative solution to the unbound granular sub-ballast used in the railway track due to several benefits that it can provide. Indeed, it contributes to maintain the moisture content in the subgrade unchanged during all year. This decreases the subgrade deterioration process. Moreover, the presence of bituminous sub-ballast can also reduce vertical stiffness variations on the track; it can have a positive effect in the maintenance needs at transition sections (bridge-embankment) and in the attenuation of the vibrations induced by the rail traffic. Despite the importance of the presence of the bituminous sub-ballast to conceive the construction and/or rehabilita…
The Quest for Raw Materials in the British Paper Trade : The Development of the Bamboo Pulp and Paper Industry in British India up to 1939
2018
The British paper trade history was defined since the mid-1850s by a quest for a new raw material to replace rags. The requirements of the paper trade were first met by a discovery that esparto grass from Spain, and later from North Africa, could be utilised in British mills. Beginning in the late 1870s, the success of using esparto encouraged mill developments in British India. The increased dependence on imported wood pulp, the likelihood of a pulp famine, and the consequent increase in price for imported wood pulp drew attention to the possibility of making commercial volumes of good quality pulp from indigenous Indian grasses. Bamboo began being treated after the First World War, when t…
¿Solamente platos? Cerámicas de barniz rojo en el depósito ibérico del Zacatín (Granada)
2015
We have taken, as a subject of our study, a homogeneous set of red indigenous glazed plates with a very particular profile and without a parallel known for the present time. The above mentioned set was part of the ritual deposit found in Zacatin, a very typical street from Granada. This deposit is a pit close to the River Darro which was filled with the waste of a sacred banquet, possibly related to this same river. In this work we consider the fact that these plates were made ex profeso for the ritual that took place out of Iliberri 's walls, around 370 B.C.
Coordination in a multi-cell multi-antenna multi-user W-CDMA system: a beamforming approach
2008
The problem of designing joint power control and optimal beamforming (JPCOB) algorithms for the downlink of a coordinated multi-cell WCDMA system is considered throughout this paper. In this case, the JPCOB design is formulated as the problem of minimizing the total transmitted power in the coordinated multi-cell system, subject to a certain quality of service requirement for each user. In this paper, the performance of two JPCOB algorithms based on different beamforming approaches is compared over the coordinated multi-cell system. The first one, obtains local beamformers by means of the well-known virtual uplink-downlink duality. In contrast, the second algorithm implements multi-base bea…
Mineralogical variability of Callovo-Oxfordian clays from the Paris Basin and the Subalpine Basin.
2006
High-resolution clay mineralogical data at the Middle/Upper Jurassic boundary from the French Subalpine Basin, the Jura Mountains and the Paris Basin (ANDRA boreholes) from Callovo-Oxfordian clayey deposits allow spatial and temporal terrigenous flux evolution to be considered over a period of 6 to 7 Myr. Recorded diachronisms of major mineralogical changes and complex clays distribution at the Paris Basin scale result to combined palaeogeographic/eustatic variations and climate input. In the French Subalpine Basin, mineralogical homogeneity confirms the burial diagenesis influence, but other terrigenous supplies must be involved in contrast to the Paris Basin domains. Volcanogenic clays (b…
Non-Indigenous Species (NIS) within Marine Protected Areas (MPAs). The case study of the Aegadian Islands MPA (Sicily, Tyrrhenian Sea) and the Dwejra…
2018
The introduction of non-indigenous species (NIS) has been pointed out as a major threat to biodiversity. NIS may become invasive alien species (IAS) and may cause biodiversity loss and ecosystem service changes. In the Mediterranean Sea, Sicily and surrounding islands, also including a high number of Marine Protected Area (MPAs), as a consequence of their geographic position and the intense maritime traffic, is a region particularly vulnerable and prone to NIS invasions. Since frontiers do not exist in the sea, biological invasions may severely affect MPAs, whose major aim is biodiversity conservation. Among the Sicilian MPAs, the Aegadian Islands MPA report the highest number of NIS (19). M…
GEOCHEMICAL AND MINERALOGICAL FINGERPRINTS OF THE SEDIMENTS SUPPLY AND EARLY DIAGENETIC PROCESSES IN THE BIZERTE LAGOON (TUNISIA)
2016
International audience; The Bizerte Lagoon (Tunisia) functions as a sedimentation environment characterized by receiving allochthonous sediments mainly transported by the Ben Hassine, Rharek and Guenich streams, as well as marine sediments from the Mediterranean Sea. It is subjected to significantenvironmental changes due to the natural and anthropic influences altering the natural patterns of circulation, extraction and/or deposition of mineralogical materials. The aim of this investigation is to analyze the sediments supply and early diagenetic processes in Bizerte Lagoon. Thephyicochemical parameter of the sediment pore water, as well as their texture, mineralogical composition (X-Ray di…