Search results for "Novobiocin"

showing 2 items of 2 documents

Geldanamycin and its derivatives as Hsp90 inhibitors

2012

The Hsp90 molecule, one of the most abundant heat shock proteins in mammalian cells, maintains homeostasis and prevents stress-induced cellular damage. Hsp90 is expressed under normal conditions at a level of about 1-2 Percent of total proteins, while its expression increases 2-10 fold in cancer cells. The two main constitutively expressed isoforms of Hsp90 are known as Hsp90-alpha and Hsp90-beta, and their upregulation is associated with tumor progression, invasion and formation of metastases, as well as development of drug resistance. The Hsp90 is a key target for many newly established, potent anticancer agents containing Hsp90 N-terminal ATP binding inhibitors, such as geldanamycin, and…

IndolesLactams MacrocyclicCyclin-Dependent KinaseAntineoplastic AgentsTanespimycinBenzoquinoneModels BiologicalAntineoplastic Agentchemistry.chemical_compoundDownregulation and upregulationTransforming Growth Factor betaCyclin-dependent kinaseHeat shock proteinBenzoquinonespolycyclic compoundsAnimalsHumansHSP90 Heat-Shock ProteinsbiologyAnimalTriazolesGeldanamycinHsp90Cyclin-Dependent KinasesProto-Oncogene Proteins c-rafHSP90 Heat-Shock Proteinsrc-Family KinaseschemistryTumor progressionMutationCancer cellbiology.proteinCancer researchMacrolidesMacrolideTriazoleTumor Suppressor Protein p53Animals; Antineoplastic Agents; Benzoquinones; Cyclin-Dependent Kinases; HSP90 Heat-Shock Proteins; Humans; Lactams Macrocyclic; Macrolides; Models Biological; Mutation; Novobiocin; Proto-Oncogene Proteins c-raf; Transforming Growth Factor beta; Triazoles; Tumor Suppressor Protein p53; src-Family KinasesNovobiocinHumanFrontiers in Bioscience
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Improved Salmonella recovery from moderate to highly polluted waters.

1982

A new enrichment procedure for the recovery of salmonellas from aquatic environments is proposed. It has been tested in a eutrophic lake showing moderate to high faecal contamination levels (the Albufera lake near Valencia, Spain), and in effluents coming into a wastewater treatment plant. The new method consists of the addition of sodium novobiocin to a modification of Rappaport's medium (R10/43°C). The new medium (NR10/43°C) allows a better recovery of salmonellas from water than selenite broth.

SalmonellaSewageEcologyAquatic ecosystemSodiumWater Pollutionchemistry.chemical_elementSelenite brothContaminationBiologymedicine.disease_causeApplied Microbiology and BiotechnologyMicrobiologyCulture MediachemistrySalmonellaEnvironmental chemistrymedicineSewage treatmentEutrophicationWater MicrobiologyEffluentNovobiocinThe Journal of applied bacteriology
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