Search results for "Np"

showing 10 items of 2567 documents

Quantitative study of ANP in hypothalamic supraoptic and paraventricular nuclei in trained rats.

2008

ANPSupraotic nucleusParaventricular nucleusTraining.Settore BIO/16 - Anatomia Umana
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Atrial natriuretic factor, but not oxytocin, is present in atherosclerotic plaques of human common carotid arteries: an immunohistochemical in vivo s…

2009

ANPoxytocinatherosclerosishuman common carotid arteries.Settore BIO/16 - Anatomia Umana
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ANP and vasopressin -presence in the ciliary body of eye in the pig, (Sus domesticus)

2014

The aqueous humor is produced in the ciliary body so, in this study we investigate on the ANP presence and vasopressin in the ciliary body of the pig eye since these peptide are involved in the homeostasis of the body fluids. The results show ANP-presence in the epithelial cells and in the endothelial cells of the blood vessels and VP-presence in the epithelial cells, in the endothelium of canal of Schelmm and in the muscle cells of the blood vessels. These peptides might regulate the synthesis and the composition of the aqueous humor and regulate the hydrodynamic flow and haemodynamic flow of the blood.

ANPvasopressinciliary bodypig eye.Settore BIO/16 - Anatomia Umana
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Objektu-relāciju kartēšanas rīku salīdzinājums ASP.NET ietvarā

2021

ORM rīki ir populāra izvēle ASP.NET lietotnes loģiskā slāņa savienošanai ar datubāzi. Tomēr jauniem izstrādātājiem ne vienmēr var būt skaidrs un zināms, kādu ORM rīku izmantot lietotnes realizācijā. “Bakalaura” darba galvenais mērķis ir izpētīt ASP.NET ORM rīku piedāvājumu un veikt savstarpēju salīdzināšanu autora izvēlētā ORM rīku izlasē. Darbā tiek izprasts, kas ir objektorientēta kartēšana, kādus ORM rīkus piedāvā ASP.NET ietvars, un tiek veikts izvēlētu ORM rīku praktisks salīdzinājums. Lai veiktu praktisku salīdzinājumu, tika izveidota ASP.NET lietotne, datubāze un vaicājumi, kas katram ORM rīkam ir jāizpilda. Praktiskā pētījuma rezultātā ir formulēti secinājumi par katru ORM rīku, ana…

ASP.NETDatorzinātneORMEntity FrameworkC#NPoco
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Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

Graphical abstract

ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
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A melanocortin 1 receptor (MC1R) gene polymorphism is useful for authentication of Massese sheep dairy products

2011

Massese is an Italian sheep breed, with black or grey coat colour, mainly reared in the Tuscany and Emilia Romagna regions. Recently, the emerging interests in this breed have resulted in the production of Pecorino cheese obtained with only Massese milk. In order to be profitable, this marketing link between Massese breed and its products should be defended against fraudsters who could include milk of other sheep breeds or cow milk in Massese labelled productions. To identify the genetic factors affecting coat colour in sheep, we have recently analysed the melanocortin 1 receptor (MC1R) gene and identified several single nucleotide polymorphisms (SNPs). In this work, as a first step to set …

AUTHENTICATION OF FOOD PRODUCTSCoatVeterinary medicineSNPFood ContaminationSingle-nucleotide polymorphismBiologyPolymerase Chain ReactionPolymorphism Single NucleotideSensitivity and SpecificityMASSESECow milkSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoGene FrequencySpecies SpecificityCheesePolymorphism (computer science)MC1RAnimalsAlleleGeneticsSheepfood and beveragesDNAGeneral MedicineBreedMilkFemaleAnimal Science and ZoologyDairy Productsauthentication Massese MC1R mono-breed products sheep breeds SNPReceptor Melanocortin Type 1DAIRY SHEEPPolymorphism Restriction Fragment LengthMc1r geneFood ScienceMelanocortin 1 receptor
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Plēsonīgo cenu jēdziens Latvijas konkurences tiesībās

2015

Plēsonīgo cenu stratēģijas realizēšana Latvijas doktrīnā līdz šim nav apskatīta. Lielākā problēma, kas saistīta ar plēsonīgajām cenām, ir plēsonīgo cenu piemērošanas nošķiršana no ikdienišķas biznesa prakses. Eiropas Savienības doktrīnā un Eiropas Savienības Tiesas praksē ir nostiprināti dažādi kritēriji, meklējot risinājumu iepriekš minētajai problēmai. Autors pētījuma gaitā analizē plēsonīgo cenu jēdzienu, kā arī Eiropas Savienības Tiesas praksi un tās piedāvātos kritērijus plēsonīgo cenu piemērošanas identificēšanai. Tāpat darba gaitā autors salīdzina Konkurences padomes nolēmumos nostiprinātos kritērijus ar Eiropas Savienības Tiesas praksi. Darbā, cita starpā, autors analizē arī Amerika…

Abuse of dominant positionAKZOPredatory pricingPlēsonīgās cenasDominējošā stāvokļa ļaunprātīga izmantošanaJuridiskā zinātne
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Addictive-like behaviour for Acetaldehyde: involvement of D2 receptors

2013

Acetaldehyde (ACD), ethanol's first metabolite, is centrally active and shows rewarding and motivational properties. It is able to activate mesolimbic dopamine system, since it enhances neuronal firing of dopamine cells in ventral tegmental area and exerts dopamine release in the nucleus accumbens (Foddai et al., 2004; Melis et al., 2007; Deehan et al., 2013). ACD motivational properties are demonstrated by self-administration studies in rodents (Rodd et al., 2005), particularly behavioural evidence suggests that ACD could produce positive reinforcing effects in operant-conflict paradigms (Cacace et al., 2012). In order to shed light on neurobiological substrate underpinning ACD-related beh…

Acetaldehyde Dopamine system Quinpirole Ropinirole D2 D2-autoreceptors modulation
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Standalone sauna vs exercise followed by sauna on cardiovascular function in non‐naïve sauna users: A comparison of acute effects

2021

Background and aimsSauna bathing and aerobic exercise have each been shown to affect cardiovascular function. However, direct comparisons between standalone sauna bathing and a combination of exercise and sauna on vascular indices remain limited. Therefore, we conducted a cross-over study using matched durations to explore the hemodynamic changes of sauna exposure when compared to a combination of aerobic exercise and sauna exposure.MethodsParticipants (N = 72) with at least one cardiovascular risk factor underwent, on two separate occasions: (a) a 30-minute sauna at 75°C (SAUNA) and (b) the combination of a 15-minute cycling exercise at 75% maximum heart rate followed by 15-minute sauna ex…

Acute effectsmedicine.medical_specialtyMean arterial pressurehypertensionsaunominenHemodynamicsvaltimotInternal medicinenon‐pharmocological therapyHeart ratekohonnut verenpainemedicineAerobic exerciseRisk factorResearch ArticlesAerobic exercisebusiness.industryRGeneral Medicineaerobinen harjoittelumedicine.diseaseverenpaineaerobic exerciseBlood pressureCardiologyArterial stiffnessMedicinelifestyle modificationnon-pharmocological therapybusinessarterial compliancefysiologiset vaikutuksetResearch ArticleHealth Science Reports
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Incident colorectal cancer in Lynch syndrome is usually not preceded by compromised quality of colonoscopy

2019

AbstractBackground: Lifetime incidence of colorectal cancer (CRC) especially in carriers of MLH1 and MSH2 pathogenic germline variants in mismatch repair genes is high despite ongoing colonoscopy s...

AdenomaAdultMaleOncologycongenital hereditary and neonatal diseases and abnormalitiesmedicine.medical_specialtyHereditary non-polyposis colorectal cancerCOLONOSCOPYColorectal cancersurveillance colonoscopyeducationColonoscopycolorectal cancerMLH1Germline03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumansRegistriesneoplasmsFinlandAgedNeoplasm StagingRetrospective Studiesmedicine.diagnostic_testbusiness.industryIncidenceIncidence (epidemiology)LYNCH SYNDROMEGastroenterologynutritional and metabolic diseasesMiddle Agedmedicine.diseaseColorectal Neoplasms Hereditary Nonpolyposisdigestive system diseasesLynch syndrome3. Good healthMSH2Population Surveillance030220 oncology & carcinogenesis3121 General medicine internal medicine and other clinical medicineFemale030211 gastroenterology & hepatologyDNA mismatch repairColorectal Neoplasmsbusiness
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