Search results for "ODD"

showing 10 items of 1532 documents

Baltu filoloģija, 24 (2)

2016

LithuanianRecenzijasUnexplained OdditiesDarbības vārdu pagātnes formas:HUMANITIES and RELIGION::Languages and linguistics::Other languages::Baltic languages [Research Subject Categories]Baltu valodasJ. Endzelīna un P. Šmita „Izrunas un rakstības vadonis“
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Hepatobiliary phase in cirrhotic patients with different Model for End-stage Liver Disease score: comparison of the performance of gadoxetic acid to …

2018

The purpose of this study was to compare the performance of gadobenate dimeglumine–enhanced MRI and gadoxetic acid–enhanced MRI in the hepatobiliary phase (HBP) in cirrhotic patients with different degrees of liver dysfunction. In this retrospective cross-sectional study, we analyzed the unenhanced phase and the HBP of 131 gadobenate dimeglumine–enhanced MRI examinations (gadobenate dimeglumine group) and 127 gadoxetic acid–enhanced MRI examinations (gadoxetic acid group) performed in 249 cirrhotic patients (181 men and 68 women; mean age, 64.8 years) from August 2011 to April 2017. For each MRI, the contrast enhancement index of the liver parenchyma was calculated and correlated to the Mod…

Liver CirrhosisAdultMaleGadolinium DTPAGadoxetic acidmedicine.medical_specialtyLiver CirrhosiContrast MediaSensitivity and SpecificitySeverity of Illness Index030218 nuclear medicine & medical imagingGadobenic acid03 medical and health sciencesLiver diseaseYoung Adult0302 clinical medicineModel for End-Stage Liver DiseaseMeglumineGadobenic acidRetrospective StudiemedicineGadolinium ethoxybenzyl DTPAOrganometallic CompoundsHumansRadiology Nuclear Medicine and imagingRetrospective StudiesNeuroradiologyAgedAged 80 and overCross-Sectional Studiemedicine.diagnostic_testMegluminebusiness.industryMagnetic resonance imagingGeneral MedicineOdds ratioMiddle Agedmedicine.diseaseMagnetic Resonance ImagingCross-Sectional Studies030220 oncology & carcinogenesisFemaleRadiologyNuclear medicinebusinessmedicine.drugHuman
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Fibronectin Type III Domain–Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Dis…

2017

Context Contrasting data have been reported on the role of irisin, a novel myokine encoded by the fibronectin type III domain-containing protein 5 (FNDC5) gene, in nonalcoholic fatty liver disease (NAFLD) pathogenesis. We tested in patients with suspected nonalcoholic steatohepatitis (NASH) the association of FNDC5 variants, hepatic expression, and circulating irisin with liver damage (F2 to F4 fibrosis as main outcome). We also investigated whether irisin modulates hepatocellular fat accumulation and stellate cell activation in experimental models. Methods We considered 593 consecutive patients who underwent liver biopsy for suspected NASH and 192 patients with normal liver enzymes and wit…

Liver CirrhosisMale0301 basic medicineEndocrinology Diabetes and MetabolismClinical BiochemistrySeverity of Illness IndexBiochemistryGastroenterologyMiceEndocrinologyNon-alcoholic Fatty Liver DiseaseFibrosisNonalcoholic fatty liver diseaseOdds RatioProspective StudiesCarbon Tetrachloridemedicine.diagnostic_testReverse Transcriptase Polymerase Chain ReactionHep G2 CellsMiddle AgedFNDC5LiverLiver biopsyFemaleAdultmedicine.medical_specialtyIn Vitro TechniquesDiet High-FatReal-Time Polymerase Chain ReactionPolymorphism Single Nucleotide03 medical and health sciencesDiabetes mellitusInternal medicineMyokineHepatic Stellate CellsmedicineAnimalsHumansFNDC5 IRISIN NAFLDGenetic Predisposition to Diseasebusiness.industryBiochemistry (medical)medicine.diseasedigestive system diseasesFibronectins030104 developmental biologyEndocrinologyCase-Control StudiesHepatic stellate cellSteatosisbusinessThe Journal of Clinical Endocrinology & Metabolism
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Association between MICA Gene Variants and the Risk of Hepatitis C Virus-Induced Hepatocellular Cancer in a Sicilian Population Sample

2018

There are currently no biomarkers that predict hepatocellular carcinoma (HCC) risk in patients with hepatitis C virus (HCV)-related cirrhosis. We investigated the relationships among major histocompatibility complex (MHC) class I chain-related gene A (MICA) polymorphisms, plasma levels of soluble MICA (sMICA), and HCC risk in patients with HCV-related HCC. One hundred fifty-four HCV-related HCC patients, 93 HCV-related liver cirrhosis (LC) cases, and 244 healthy controls, all sampled from the native Sicilian population, were genotyped using the KASP™ single-nucleotide polymorphism genotyping method. The MICA rs2596542 polymorphism showed that the G/G genotype was significantly more frequent…

Liver CirrhosisMale0301 basic medicineGenetic LinkageHepacivirusHepacivirusmedicine.disease_causeGastroenterologyBiochemistryLinkage DisequilibriumMiceLiver disease0302 clinical medicineGenotypeOdds RatioAged 80 and overeducation.field_of_studybiologyHepatitis Chepatocellular carcinomaMiddle AgedHepatitis CItalyPopulation Surveillance030220 oncology & carcinogenesisHepatocellular carcinomagenetic association studyHCVMolecular MedicineFemaleDisease SusceptibilityCell-Free Nucleic AcidsBiotechnologymedicine.medical_specialtyCarcinoma HepatocellularGenotypeHepatitis C virusPopulation03 medical and health sciencesInternal medicinemedicineGeneticsAnimalsHumanseducationMolecular BiologyAllelesAgedbusiness.industryliver cirrhosiDecision TreesHistocompatibility Antigens Class IGenetic VariationOdds ratiomedicine.diseasebiology.organism_classificationdigestive system diseases030104 developmental biologyMICAbusinessBiomarkers
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Effectiveness of telaprevir or boceprevir in treatment-experienced patients with HCV genotype 1 infection and cirrhosis. : Triple therapy in HCV geno…

2014

International audience; BACKGROUND & AIMS: We investigated the effectiveness of the protease inhibitors peginterferon and ribavirin in treatment-experienced patients with hepatitis C virus (HCV) genotype 1 infection and cirrhosis. METHODS: In the Compassionate Use of Protease Inhibitors in Viral C Cirrhosis study, 511 patients with HCV genotype 1 infection and compensated cirrhosis who did not respond to a prior course of peginterferon and ribavirin (44.3% relapsers or patients with viral breakthrough, 44.8% partial responders, and 8.0% null responders) were given either telaprevir (n = 299) or boceprevir (n = 212) for 48 weeks. We assessed percentages of patients with sustained viral respo…

Liver CirrhosisMaleCirrhosisComorbidityHepacivirusmedicine.disease_causeGastroenterologyPolyethylene GlycolsTelaprevirCohort Studieschemistry.chemical_compound0302 clinical medicinePegylated interferonboceprevirProspective StudiesTreatment FailureAged 80 and overGastroenterologyMiddle AgedRecombinant Proteins3. Good healthTreatment Outcome030220 oncology & carcinogenesisDrug Therapy CombinationFemale030211 gastroenterology & hepatologyOligopeptidesmedicine.drugAdultmedicine.medical_specialtyGenotypeProlineHepatitis C virusAntiviral Agents03 medical and health sciencesBoceprevirInternal medicineRibavirinmedicinechronic hepatitis CHumanstelaprevirAdverse effect[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular BiologyAgedHepatologybusiness.industrycirrhosisRibavirinInterferon-alphaOdds ratioHepatitis C Chronicmedicine.diseasechemistryMultivariate AnalysisImmunologybusinessFollow-Up StudiesGastroenterology
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Altered postural control and stability in cirrhotic patients with minimal hepatic encephalopathy correlate with cognitive deficits

2017

Background & Aims: Cognitive dysfunction in cirrhotic patients with minimal hepatic encephalopathy (MHE) is associated with falls. Alterations in postural control and stability could contribute to increase falls risk in these patients. We aimed to assess whether postural control and direction-specific limits of stability are altered in cirrhotic patients with MHE compared to patients without MHE and controls. We also assessed if alterations in postural control correlate with neurological impairment and/or blood biomarkers. Methods: Posturography analysis, attention Stroop test and bimanual and visuo-motor coordination tests were performed in 18 controls, 19 patients with cirrhosis without M…

Liver CirrhosisMaleCirrhosisPsychometricslimits of stabilityminimal hepatic encephalopathypostural control03 medical and health sciencesCognition0302 clinical medicineAmmoniaPredictive Value of TestsRisk FactorsfallsOdds RatiomedicineHumansAttentionPhysical ExaminationPostural BalanceHepatic encephalopathyBalance (ability)Chi-Square DistributionHepatologyImpaired Balancebusiness.industryInterleukinsPosturographyCognitionMiddle Agedmedicine.diseaseMotor coordinationLogistic ModelsCase-Control StudiesHepatic EncephalopathyAnesthesiaMultivariate AnalysisSensation DisordersStroop TestAccidental FallsFemale030211 gastroenterology & hepatologyCognition Disordersbusinesshuman activitiesPsychomotor Performance030217 neurology & neurosurgeryStroop effect
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Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis

2015

ABSTRACT Contrasting data exist on the effect of gender and menopause on the susceptibility, development and liver damage progression in non-alcoholic fatty liver disease (NAFLD). Our aim was to assess whether menopause is associated with the severity of liver fibrosis in individuals with NAFLD and to explore the issue of ovarian senescence in experimental liver steatosis in zebrafish. In 244 females and age-matched males with biopsy-proven NAFLD, we assessed anthropometric, biochemical and metabolic features, including menopausal status (self-reported); liver biopsy was scored according to ‘The Pathology Committee of the NASH Clinical Research Network’. Young and old male and female zebraf…

Liver CirrhosisMaleFibrosiBiopsyPhysiologylcsh:MedicineMedicine (miscellaneous)Body Mass IndexCohort StudiesImmunology and Microbiology (miscellaneous)FibrosisNon-alcoholic Fatty Liver DiseaseRisk FactorsOdds RatioZebrafishCellular Senescencemedicine.diagnostic_testAnthropometryFatty liverMiddle AgedOvarian senescenceMenopauseLiver biopsyModels AnimalDisease ProgressionFemaleMenopauselcsh:RB1-214Research ArticleSenescenceAdultmedicine.medical_specialtyFibrosis Menopause Non-alcoholic fatty liver disease Ovarian senescence ZebrafishNeuroscience (miscellaneous)Fibrosis; Menopause; Non-alcoholic fatty liver disease; Ovarian senescence; Zebrafish; Biochemistry Genetics and Molecular Biology (all); Medicine (miscellaneous); Immunology and Microbiology (miscellaneous); Neuroscience (miscellaneous)BiologyReal-Time Polymerase Chain ReactionGeneral Biochemistry Genetics and Molecular BiologyInternal medicinemedicinelcsh:PathologyAnimalsHumansAgedBiochemistry Genetics and Molecular Biology (all)lcsh:RSettore MED/09 - MEDICINA INTERNAOvaryOdds ratiomedicine.diseaseFibrosisEndocrinologySteatosisBody mass indexDisease Models & Mechanisms
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Oral lichen planus, hepatitis C virus, and HIV: no association in a cohort study from an area of high hepatitis C virus endemicity

2004

Abstract Objectives We sought to assess the age-specific prevalence of oral lichen planus (OLP) in Mediterranean patients with chronic hepatitis C virus (HCV) and to evaluate the features of OLP in relation to sex, smoking, HCV genotype, HIV-1 coinfection, and antiviral treatments. Methods In all, 178 anti-HCV-positive adults (60 women and 118 men; age range 20-66 years) recruited from two cohorts (104 HIV-negative patients and 74 patients with HIV coinfection) underwent oral examination. Results Overall prevalence of OLP was 2.8% (5 of 178) (male/female ratio 0.2; odds ratio=0.119; 95% confidence interval=0.013-1.106), only among HIV-negative participants, always in the reticular pattern, …

Liver CirrhosisMaleHepacivirusHIV Infectionsclinical-featureComorbidityHepacivirusmedicine.disease_causeCohort Studieschemistry.chemical_compoundPrevalenceMedicineExtrahepatic manifestationbiologySmokingvirus diseasesMiddle AgedHepatitis CCoinfectionFemalegeneral-populationmedicine.drugAdultmedicine.medical_specialtyGenotypeHepatitis C virushuman-immunodeficiency-viruDermatologyHCV hyperendemic areaAntiviral AgentsFlaviviridaeAge Distributionstomatognathic systemInternal medicineHumansInterferon alfaAgedbusiness.industryRibavirinChronic active hepatitiOdds ratiomedicine.diseasebiology.organism_classificationstomatognathic diseaseschemistrypositive patientsImmunologynegative patientliver-diseaseOral lichen planusinterferon therapybusinessLichen Planus Oral
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Early menopause is associated with lack of response to antiviral therapy in women with chronic hepatitis C.

2011

Background & Aims Chronic hepatitis C (CHC) and liver fibrosis progress more rapidly in men and menopausal women than in women of reproductive age. We investigated the associations among menopause, sustained virologic response (SVR), and liver damage in patients with CHC. Methods We performed a prospective study of 1000 consecutive, treatment-naive patients 18 years of age and older with compensated liver disease from CHC. Liver biopsy samples were analyzed (for fibrosis, inflammation, and steatosis) before patients received standard antiviral therapy. From women (n = 442), we collected data on the presence, type, and timing of menopause; associated hormone and metabolic features; serum lev…

Liver CirrhosisMaleTime Factorsmedicine.medical_treatmentBiopsyMenopause PrematuremenopauseHepacivirusmedicine.disease_causeGastroenterologySeverity of Illness IndexRisk FactorsOdds RatioProspective StudiesTreatment FailureProspective cohort studymedicine.diagnostic_testGastroenterologyAge FactorsHormone replacement therapy (menopause)Hepatitis CMiddle AgedViral LoadImmunohistochemistryMenopauseItalyLiver biopsyRNA ViralFemaleInflammation Mediatorshcv svr menopauseViral loadAdultmedicine.medical_specialtyantiviral therapy; menopause; prognostic factors; hcv therapyGenotypeHepatitis C virusAntiviral AgentsRisk AssessmentSex FactorsInternal medicinehcvmedicineHumanshcv; ifn; menopauseHepatologybusiness.industryInterleukin-6Tumor Necrosis Factor-alphaOdds ratioHepatitis C Chronicmedicine.diseaseifnEndocrinologyLogistic ModelsbusinessBiomarkersGastroenterology
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Anticardiolipin antibodies in patients with liver disease.

1999

OBJECTIVE: Our aim was to test the hypothesis that anticardiolipin antibodies (aCL) may cause an antiphospholipid syndrome and thrombotic events in patients with liver disease. METHODS: aCL were measured in 116 healthy controls and 372 patients with liver disease of different stage and etiology: 136 cases secondary to hepatitis C virus (HCV) infection, 139 due to hepatitis B virus (HBV) infection, 69 with alcoholic liver damage, and 28 cryptogenic in origin. Prior thrombotic events were recorded. The results were related to age, gender, stage, severity, and etiology of the liver disease, as well as to the occurrence of organ- and nonorgan-specific autoantibodies. RESULTS: aCL were positive …

Liver CirrhosisMalemedicine.medical_specialtyAlcoholic liver diseasemedicine.disease_causeGastroenterologyLiver diseaseHepatitis B ChronicAntiphospholipid syndromeInternal medicinemedicineHumansAutoantibodiesHepatitis B virusHepatologybusiness.industryLiver DiseasesGastroenterologyMuscle SmoothThrombosisOdds ratioHepatitis CHepatitis C ChronicMiddle AgedHepatitis BAntiphospholipid Syndromemedicine.diseaseLogistic ModelsAntibodies AnticardiolipinHepatocellular carcinomaChronic DiseaseImmunologyFemalebusiness
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