Search results for "ODR"
showing 10 items of 434 documents
“When You Thought That There Is No One and Nothing”: The Value of Psychodrama in Working With Abused Women
2018
This paper discusses how psychodrama methods and techniques can empower abused women and stimulate changes in their victim role. Through an in-depth exploration, we sought to gain an insider’s perspective of the experiences of change and perceived outcomes for abused women, which could contribute to optimizing gender violence intervention. Theoretically, the study is grounded in the female co-responsibility and trans-generational transmission of women’s victim role from mother to daughter. A mixed methods experimental design employing an explanatory sequential approach to data collection was implemented. A total sample of 33 abused women (15 in the experimental group, and 18 in the control …
Oxidation of carbidopa by tyrosinase and its effect on murine melanoma
2009
Oxidation of the anti-Parkinsonian agent carbidopa by tyrosinase was investigated. The products of this reaction were identified as 3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid and 6,7-dihydroxy-3-methylcinnoline. These results demonstrate that after oxidation of the catechol moiety to an o-quinone either a redox exchange with the hydrazine group or a cyclization reaction occur. The cyclization product underwent additional oxidation reactions leading to aromatization. The cyclization reaction is undesired in the case of hydrazine-containing anti-melanoma prodrugs and will have to be taken into account in designing such compounds. Carbidopa was tested against B16(F10) melanoma cells in cul…
Indirect oxidation of the antitumor agent procarbazine by tyrosinase—Possible application in designing anti-melanoma prodrugs
2008
The interaction of tyrosinase with the anticancer drug procarbazine has been investigated. In the presence of the enzyme alone no oxidation of this dialkylhydrazine above the background level was observed. However, when phenolic substrates (4-tert-butylcatechol or N-acetyl-l-tyrosine) were included in the reaction mixture, procarbazine was rapidly degraded. Oxygen consumption measurements showed that in a mixture both the phenolic substrate and the drug were oxidized. The major product of procarbazine degradation was isolated and identified as azoprocarbazine, the first active metabolite of this drug detected in previous in vivo and in vitro studies. This indirect oxidation of the hydrazine…
La heráldica en la puerta de los Apóstoles de la Catedral de Valencia
2013
Sobre la controversia en torno a la mejora moral
2019
El personaje de la nodriza en las tragedias de Séneca
2003
La nodriza de las tragedias de Séneca es un personaje secundario en la historia que se narra y en el formato dramático con el que se narra. Pero se le han concedido ciertos esbozos de diversidad que podrían haberles abierto un camino por el que ir dejando atrás su categoría de mero carácter. Por otra parte, todas en general y la de Fedra en particular, tienen un papel protagonista a la hora de plasmar y concretar en los episodios de la vida las enseñanzas morales que el autor quiere trasmitir. Y posiblemente también a la hora de reflexionar en lo profundo de su intimidad sobre las paradojas o incluso deficiencias del sistema que cree, o quiere creer, que es una solución al problema del homb…
Entrevista a Julian Savulescu: La evolución ha equipado al animal humano para decidir su propio destino
2019
Conversación con Baltasar Garzón
2021
El Santísimo Cristo del Rescate y su procesión delante del Palacio Real de Valencia
2010
María de Fonseca (c. 1486-1521) and the Marquis of Zenete (1473-1523): Aristocratic Rebels and Patrons of Renaissance Culture
2016
La historia de Rodrigo Díaz de Vivar, marqués de Zenete, el hijo primogénito del Cardenal Mendoza, y su segunda mujer María de Fonseca podría proporcionar a un escritor material más que suficiente para escribir una novela apasionante, y ciertamente merece ser mejor conocida, sobre todo en el mundo anglófono. Entre otras cosas, este artículo arroja algo de luz sobre la condición social vulnerable de la mujer en España durante la baja Edad Media y el Renacimiento, cuando había más oportunidades educativas para las damas de la nobleza, y pone en duda el supuesto papel jugado por la reina Isabel en defensa de la libertad y los derechos de la mujer; y discute cómo el marqués de Zenete expresó su…