Search results for "ODR"
showing 10 items of 434 documents
La reproducción asistida y la filiación. Especial referencia al caso de las parejas de mujeres homosexuales
2018
This paper analyses, in general, the evolution that has had the art. 7.3 LTRHA since its introduction by the Act 3/2007, 15 march. In that way, it shows which has been the legislator´s solution about the use of assisted reproduction tecniques by homosexual women couples. Likewise, it studies which resolutions on the matter have been more relevant in the last years. All this, to set out the legislator´s failure and the need to reformulate the filiation regime in face of the challenge that assisted reproduction implies.
Anulación del privacy shield en las transferencias internacionales de datos : ¿presenciamos un desplazamiento fáctico de la responsabilidad?
2021
This study provides a comprehensive analysis of international transfers of personal data to third countries or international organizations due to new privacy regulation. More specifically, it analyzes the effects on this regulatory scheme of the annulment of the Privacy Shield in the transatlantic information movements between the European Union and the United States and how this implies, in fact, a transfer of responsibility to the controller
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Acceso a la Justicia de los Consumidores a través del ADR y del ODR
2018
El avance de las tecnologías de información y la comunicación nos ha llevado a cambiar nuestra forma de relacionarnos tanto entre nosotros, como con las administraciones. Además, la adquisición de bienes de consumo a través del medio online es cada día más importante para en la economía global y doméstica. Todo ello, llevó a la Unión Europea a la creación del llamado Mercado Único Digital, donde se estableció como uno de los objetivos prioritarios mejorar la tutela efectiva de los ciudadanos comunitarios que realizan compras a través de internet. El presente trabajo tiene por objeto realizar un análisis sobre las facilidades y dificultades que encuentran los consumidores a la hora de accede…
Principal Poincar\'e Pontryagin Function associated to some families of Morse real polynomials
2014
It is known that the Principal Poincar\'e Pontryagin Function is generically an Abelian integral. We give a sufficient condition on monodromy to ensure that it is an Abelian integral also in non generic cases. In non generic cases it is an iterated integral. Uribe [17, 18] gives in a special case a precise description of the Principal Poincar\'e Pontryagin Function, an iterated integral of length at most 2, involving logarithmic functions with only one ramification at a point at infinity. We extend this result to some non isodromic families of real Morse polynomials.
The effect duration of candesartan cilexetil once daily, in comparison with enalapril once daily, in patients with mild to moderate hypertension.
2001
To determine the antihypertensive efficacy, effect duration and safety of the angiotensin II type 1 receptor blocker candesartan cilexetil and the angiotensin converting enzyme inhibitor enalapril once daily in patients with mild to moderate hypertension.A multicenter, randomised, double-blind parallel group study was performed in Finland, France, the Netherlands, Spain and Sweden. Three-hundred-and-ninety-five men and women in the age range 20-80 years with primary hypertension were randomised to an 8-week double-blind treatment period with either candesartan cilexetil 8-16 mg or enalapril 10-20 mg once daily, with forced dose titration after 4 weeks. Non-invasive ambulatory blood pressure…
Antecedents of manic versus other first psychotic episodes in 263 bipolar I disorder patients.
2013
Objective As initial episode type can predict later morbidity in bipolar disorder, we tested the hypothesis that clinical antecedents might predict initial episode types. Method We studied 263 first-episode, adult, DSM-IV-TR type I bipolar disorder (BD-I) subjects within the McLean-Harvard-International First-Episode Project. Based on blinded assessments of antecedents from SCID examinations and clinical records, we compared first lifetime manic vs. other (mixed, depressive, or non-affective) major psychotic episodes. Results We identified 32 antecedents arising at early, intermediate or later times, starting 12.3 ± 10.7 years prior to first lifetime major psychotic episodes. Based on multi…
Influence of loperamide and loperamide oxide on the anal sphincter
1992
The objective of this study was to investigate the effects of the opioid loperamide and its recently synthesized pharmacologically inactive prodrug loperamide oxide on the anal sphincter. In a double-blind, placebo-controlled crossover study, anorectal manometry was performed in 12 healthy volunteers five hours after oral bolus application of 10 mg of loperamide, loperamide oxide, or placebo. Loperamide significantly increased the threshold volumes for minimal perception and urgency to defecate (P less than 0.05) and raised the volume required to abolish recovery of the rectoanal inhibitory reflex (P less than 0.05). These findings suggest that loperamide has a specific continence-improving…
Activation-Induced Rigidity in Neurologically and Cognitively Healthy Individuals Aged 18-90 Years: A Cross-Sectional Study.
2021
Background: Rigidity is a key clinical feature of Parkinson’s disease (PD), but in a very early phase of the disease it may be absent and can be enhanced through active movements of the arm contralateral to the one being tested. Objective: To evaluate in a large cohort of neurologically and cognitively healthy (NCH) subjects aged 18–90 years if activation-induced rigidity (AR) is present in all age classes, and if there are biological differences between subjects showing AR (AR+) and not showing AR (AR-). Methods: 2,228 NCH subjects categorized as young adult (18–44 years), adult (45–64 years), elderly (65–74 years), and old/oldest-old (75–90 years) were included in the analysis, and underw…