Search results for "OMAS"
showing 10 items of 1725 documents
Pharmacologic screen identifies active combinations with BET inhibitors and LRRK2 as a novel putative target in lymphoma
2022
Inhibitors of the Bromo- and Extra-Terminal domain (BET) family proteins have strong preclinical antitumor activity in multiple tumor models, including lymphomas. Limited single-agent activity has been reported in the clinical setting. Here, we have performed a pharmacological screening to identify compounds that can increase the antitumor activity of BET inhibitors in lymphomas. The germinal center B-cell like diffuse large B-cell lymphoma (DLBCL) cell lines OCI-LY-19 and WSU-DLCL2 were exposed to 348 compounds given as single agents at two different concentrations and in combination with the BET inhibitor birabresib. The combination partners included small molecules targeting important bi…
LE METODICHE ANALITICHE
2022
Il processo analitico è frutto di una serie di tappe fondamentali (Fig. 13.1) che devono permettere di raggiungere lo scopo prefissato: ottenere un’informazione puntuale sul campione sottoposto ad analisi. Le scelte legate alla procedura di campionamento, di pretrattamento del campione e del metodo di analisi sono fortemente influenzate dal tipo di matrice, dal tipo di analita o del parametro da determinare e dal grado di incertezza tollerabile sul risultato finale affinché sia conforme alle esigenze normative, disciplinari o di indagine scientifica. Il campione, inteso come quantità di materia che si sottopone ad analisi, deve essere un’aliquota rappresentativa e omogenea della biomassa ne…
Un labirinto del tardo Quattrocento nel giardino di Giovan Tomaso Moncada
2017
Da un manoscritto databile intorno al 1550 e un saggio a stampa sulle feste reali celebrate a Palermo, pubblicato nel 1703, sappiamo dell'esistenza di un labirinto nel giardino dell'aristocratico Giovan Tomaso Moncada, costruito negli anni settanta o negli anni ottanta del XV secolo nella campagna vicino Palermo. Si tratta della scena in cui ebbe luogo un ricco banchetto offerto al Viceré Ferdinando de Acuña. Secondo l'autore del manoscritto, Gian Giacomo Adria, modello di riferimento per il labirinto siciliano era quello cretese del Minotauro e lo stesso aveva forma quadrata, con otto circuiti, circondato da un muro decorato con un motivo a chiavi spezzate. Sebbene non abbiamo elementi suf…
Assessment of bioenergy potential in Sicily: a GIS-based support methodology
2008
Abstract A Geographical Information System (GIS) supported methodology has been developed in order to assess the technical and economic potential of biomass exploitation for energy production in Sicily. The methodology was based on the use of agricultural, economic, climatic, and infrastructural data in a GIS. Data about land use, transportation facilities, urban cartography, regional territorial planning, terrain digital model, lithology, climatic types, and civil and industrial users have been stored in the GIS to define potential areas for gathering the residues coming from the pruning of olive groves, vineyards, and other agricultural crops, and to assess biomass available for energy cu…
Sorption of copper(II) ions in the biomass of alga Spirogyra sp.
2012
Abstract Sorption of copper ions by the alga Spirogyra sp. was investigated to determine the influence of experimental conditions and the methods of sample preparation on the process. The experiments were carried out both under the static and the dynamic conditions. Kinetics and equilibrium parameters of the sorption were evaluated. In addition, the influence was studied of the algae preparation methods on the conductivity of demineralized water in which the algae samples were immersed. The static experiments showed that the sorption of Cu2+ ions reached equilibrium in about 30 min, with approximately 90% of the ions adsorbed in the initial 15 min. The sorption capacity determined from the …
Designing biochar properties through the blending of biomass feedstock with metals: Impact on oxyanions adsorption behavior
2018
Metal-blending of biomass prior to pyrolysis is investigated in this work as a tool to modify biochar physico-chemical properties and its behavior as adsorbent. Six different compounds were used for metal-blending: AlCl3, Cu(OH)2, FeSO4, KCl, MgCl2 and Mg(OH)2. Pyrolysis experiments were performed at 400 and 700 °C and the characterization of biochar properties included: elemental composition, thermal stability, surface area and pore size distribution, Zeta potential, redox potential, chemical structure (with nuclear magnetic resonance) and adsorption behavior of arsenate, phosphate and nitrate. Metalblending strongly affected biochars' surface charge and redox potential. Moreover, it incre…
Probing Lorentz invariance and other fundamental symmetries in3He/129Xe clock-comparison experiments
2011
We discuss the design and performance of a very sensitive low-field magnetometer based on the detection of free spin precession of gaseous, nuclear polarized 3He or 129Xe samples with a SQUID as magnetic flux detector. Characteristic spin precession times T*2 of up to 60 h were measured in low magnetic fields (about 1μT) and in the regime of motional narrowing. With the detection of the free precession of co-located 3He/129Xe nuclear spins (clock comparison), the device can be used as ultra-sensitive probe for non-magnetic spin interactions, since the magnetic dipole interaction (Zeeman-term) drops out in the weighted frequency difference, i.e., Δω = ωHe− γHe/γXe·ωXe. We report on searches …
PML down-regulation in soft tissue sarcomas
2010
To date, little is known concerning the promyelocytic leukemia gene (PML) status in tumors of different origin, and its expression has never been evaluated in soft tissue sarcoma. The aim of the present study is focused on the identification of differences in terms of PML protein expression between different types of soft tissue sarcoma and the corresponding normal surrounding tissue. PML protein expression has been assessed by immunohistochemistry in six different histologic types of soft tissue sarcoma (synovial sarcoma, myofibroblastic sarcoma, angiosarcoma, liposarcoma, pleomorphic sarcoma, and leiomyosarcoma) and in the corresponding normal surrounding tissue. PML resulted significantl…
Retroperitoneale Sarkome: Diagnostik und Therapie
2006
Background Due to the fact that there are no distinct anatomical compartments, retroperitoneal sarcomas are moreover diagnosed with evidence of large tumors and infiltration of adjacent organs. In spite of improvement of the diagnostic facilities and surgical techniques, quite frequently local recurrences with unfavourable prognosis turn up even after complete removal. It was the aim of this study to analyze diagnosis, therapy and long-term prognosis in patients with retroperitoneal sarcomas over a period of 10 years. Patients and methods Between January 1995 and January 2005, 379 patients underwent surgery for a primary retroperitoneal tumor at our clinic. Among the 67 (17.1 %) malignant l…
Zola «onomaturge»: le sens et la portée symbolique des anthroponymes dans "Les Rougon-Macquart"
2016
Throughout the twenty volumes of his monumental novel series, Emile Zola carefully chose his characters’ family names and given names, looking for clues in authentic documents or inventing some new anthroponyms himself. The main principle of the relation between a character and his/her family name is the name’s meaning and the symbolical significance hidden in its phonetic and semantic structure. As far as the given names are concerned, their choice usually seems to be determined by irony, the writer’s favorite literary technique.