Search results for "OMEGA"
showing 10 items of 1174 documents
Enrichment of Immediate-Early 1 (m123/pp89) Peptide-Specific CD8 T Cells in a Pulmonary CD62LloMemory-Effector Cell Pool during Latent Murine Cytomeg…
2000
ABSTRACTInterstitial cytomegalovirus (CMV) pneumonia is a clinically relevant complication in recipients of bone marrow transplantation (BMT). Recent data for a model of experimental syngeneic BMT and concomitant infection of BALB/c mice with murine CMV (mCMV) have documented the persistence of tissue-resident CD8 T cells after clearance of productive infection of the lungs (J. Podlech, R. Holtappels, M.-F. Pahl-Seibert, H.-P. Steffens, and M. J. Reddehase, J. Virol. 74:7496–7507, 2000). It was proposed that these cells represent antiviral “standby” memory cells whose functional role might be to help prevent reactivation of latent virus. The pool of pulmonary CD8 T cells was composed of two…
Prevention of long-term IgE antibody production by gene gun-mediated DNA vaccination.
2004
Background Vaccination with allergen-encoding DNA represents a promising approach for the treatment of allergic diseases. Objective In a mouse model of type I allergy, we analyzed the ability of biolistic transfection to inhibit antigen-specific IgE production and to modulate T H 2 responses. Methods BALB/c mice were vaccinated by means of gene gun–mediated DNA immunization with plasmid vector pCMV-βGal, encoding β-galactosidase as a model allergen. Subsequently, mice were immunized by means of repeated intraperitoneal injection of β-galactosidase adsorbed to the adjuvant aluminum hydroxide. Development of IgE, IgG1, and IgG2a antibody titers during the course of immunization was followed, …
Murine model of interstitial cytomegalovirus pneumonia in syngeneic bone marrow transplantation: persistence of protective pulmonary CD8-T-cell infil…
2000
ABSTRACTInterstitial pneumonia (IP) is a severe organ manifestation of cytomegalovirus (CMV) disease in the immunocompromised host, in particular in recipients of bone marrow transplantation (BMT). Diagnostic criteria for the definition of CMV-IP include clinical evidence of pneumonia together with CMV detected in bronchoalveolar lavage or lung biopsy. We have used the model of syngeneic BMT and simultaneous infection of BALB/c mice with murine CMV for studying the pathogenesis of CMV-IP by controlled longitudinal analysis. A disseminated cytopathic infection of the lungs with fatal outcome was observed only when reconstituting CD8 T cells were depleted. Neither CD8 nor CD4 T cells mediated…
Clinical virology of cytomegalovirus infection following hematopoietic transplantation
2010
Cytomegalovirus (CMV) causes significant morbidity and mortality in allogeneic stem cell transplant recipients. The incidence of early CMV disease has been dramatically reduced by use of preemptive therapeutic strategies. Nevertheless, a trend toward a later appearance of CMV disease is being increasingly recognized. Currently, quantitative real-time PCR assays are the first-line choice for monitoring active CMV infection. However, no threshold DNAemia levels for triggering the initiation of preemptive therapy have been clinically validated in large studies. Although more time limited than universal prophylaxis, preemptive therapy strategies may also result in over treatment. Combined viro…
"Table 36" of "Measurements of Forward Proton Production with Incident Protons and Charged Pions on Nuclear Targets at the CERN Proton Synchroton"
2010
Differential cross section for proton production with a proton beam and Aluminium target in the angular range 0.200 to 0.250 radians. The errors are the square-root of the diagonal elements of the covariant matrix.
"Table 33" of "Measurements of Forward Proton Production with Incident Protons and Charged Pions on Nuclear Targets at the CERN Proton Synchroton"
2010
Differential cross section for proton production with a proton beam and Aluminium target in the angular range 0.050 to 0.100 radians. The errors are the square-root of the diagonal elements of the covariant matrix.
"Table 11" of "Measurements of Forward Proton Production with Incident Protons and Charged Pions on Nuclear Targets at the CERN Proton Synchroton"
2010
Differential cross section for proton production with a proton beam and Beryllium target in the angular range 0.150 to 0.200 radians. The errors are the square-root of the diagonal elements of the covariant matrix.
"Table 10" of "Measurements of Forward Proton Production with Incident Protons and Charged Pions on Nuclear Targets at the CERN Proton Synchroton"
2010
Differential cross section for proton production with a proton beam and Beryllium target in the angular range 0.100 to 0.150 radians. The errors are the square-root of the diagonal elements of the covariant matrix.
"Table 12" of "Measurements of Forward Proton Production with Incident Protons and Charged Pions on Nuclear Targets at the CERN Proton Synchroton"
2010
Differential cross section for proton production with a proton beam and Beryllium target in the angular range 0.200 to 0.250 radians. The errors are the square-root of the diagonal elements of the covariant matrix.
"Table 9" of "Measurements of Forward Proton Production with Incident Protons and Charged Pions on Nuclear Targets at the CERN Proton Synchroton"
2010
Differential cross section for proton production with a proton beam and Beryllium target in the angular range 0.050 to 0.100 radians. The errors are the square-root of the diagonal elements of the covariant matrix.