Search results for "ONCE"

Data from: Sublethal streptomycin concentrations and lytic bacteriophage together promote resistance evolution

2017

Sub-minimum inhibiting concentrations (sub-MICs) of antibiotics frequently occur in natural environments owing to wide-spread antibiotic leakage by human action. Even though the concentrations are very low, these sub-MICs have recently been shown to alter bacterial populations by selecting for antibiotic resistance and increasing the rate of adaptive evolution. However, studies are lacking on how these effects reverberate into key ecological interactions, such as bacteria–phage interactions. Previously, co-selection of bacteria by phages and antibiotic concentrations exceeding MICs has been hypothesized to decrease the rate of resistance evolution because of fitness costs associated with re…

Concentric force enhancement during human movement

2001

In order to understand the possible mechanisms contributing to enhanced concentric performance in stretch-shortening cycle exercises in vivo the present study examined knee extension torque, electromyogram (EMG) activity and fascicle length of the vastus lateralis muscle in maximal and submaximal human movements. Maximal concentric knee extensions (120 degrees s(-1)) were done after pre-stretch and pre-isometric conditions by nine volunteers. During shortening at the knee angle of 115 degrees (180 degrees = extended) the knee extension torque was found to be greater in pre-stretch condition (272 vs. 248 N m, P < 0.05) although the torque level prior to shortening was smaller than in pre-iso…

 A Mechanistic Approach to theIn VivoAnti-Inflammatory Activity of Sesquiterpenoid Compounds Isolated fromInula viscosa

2001

The present study was designed to examine the anti-inflammatory activity of the sesquiterpenoids ilicic acid and inuviscolide, isolated from Inula viscosa, on cell degranulation, leukotriene biosynthesis, neurogenic drive and glucocorticoid-like interactions. Swiss female mice were used to measure the ear oedema induced by phorbol esters or ethyl phenylpropiolate (EPP), and the paw oedema induced by phospholipase A(2) (PLA(2)) or serotonin. Drug treatment consisted of one topically-applied dose in the ear models and a subcutaneous or intraperitoneal injection in the paw models. Quantitative analysis of leukotriene B(4) (LTB(4)) formation was performed on rat peritoneal neutrophils by high p…

Synthesis of azoxystrobin transformation products and selection of monoclonal antibodies for immunoassay development

2012

The use of agrochemicals for crop protection may result in the presence of toxic residues in soils and aquatic environments, besides in foodstuffs. Most often just the parent compound is included in the definition of pesticide residue, even though chemicals resulting from biotransformation and degradation routes might also be of toxicological relevance. Azoxystrobin is a broad-spectrum systemic fungicide widely used worldwide to combat pathogenic fungi affecting plants. We herein report the synthesis and detailed chemical characterization of several of the most relevant metabolites and degradates of azoxystrobin. These compounds were further employed as ligands for screening a collection of…

An epidemiological study exploring a possible impact of treatment with ACE inhibitors or angiotensin receptor blockers on ACE2 plasma concentrations

2020

Concentric and/or Eccentric Training-Induced Alterations in Shoulder Flexor and Extensor Strength

1997

To examine the effect of specific concentric and eccentric training on muscular strength following an initial standardized period of excessive training, shoulder extensors and flexors were tested. The shoulder is a joint particularly susceptible to injury and requires a specific strength training program. For a period of 12 weeks, subjects performed training, including concentric and eccentric actions. Thereafter, they were divided into three groups that performed specific 12-week programs, including either concentric (C-E/C), eccentric (C-E/E), or a combination of both concentric and eccentric exercises (C-E/C-E). Following the initial period of training, significant increases (p0.05) in p…

Motor unit discharge rate in dynamic movements of the aging soleus

2014

Aging is related to changes at the muscular level, leading to a decline in motor performance increasing the risk of falling and injury. It seems that the age-related changes in motor unit activation are muscle- and intensity dependent. The purpose of this study was to examine possible differences in soleus motor unit discharge rate (MUDR) in both isometric and dynamic contractions between young and elderly adults. 11 young (YOUNG) and 8 elderly (OLD) males participated in the study. The subjects performed isometric and dynamic plantar flexions while seated in an ankle dynamometer. The force levels studied were 10, 20, 40, 60, 80 and 100% of the isometric (ISO) MVC in ISO and 10, 20 and 40% …

Tagesprofile von Plasmaaldosteron,-Cortisol, -Renin, -Angiotensinogen und -Angiotensinasen bei Normalpersonen

1976

Plasma cortisol and renin were estimated in 1 h intervals, plasma aldosterone, angiotensinogen and angiotensinases in 3 h intervals over periods of 24 h in six normal volunteers (age 20-26) under control conditions and subsequently under suppression of ACTH release by dexamethasone. Highest cortisol levels were found around 7 a.m., minimum levels between 9 p.m. and 1 a.m. Dexamethasone reduced cortisol to constantly low concentrations. Aldosterone was highest around 4 a.m. under control conditions and under dexamethasone, and showed lowest concentrations between 4 and 10 p.m. There were no significant differences between mean aldosterone concentrations at corresponding time points of the co…

Abnormal Nailfold Capillaries in Patients after Hand Transplantation

2020

Background: The development of graft vasculopathy may play a role in the long-term deterioration of hand grafts. The aim of study was to examine the patterns of the nailfold capillaries in hand transplant recipients. Methods: the study was performed on six patients who received hand transplantation. To normalize for the effect of immunosuppression an age- and sex-matched group of 12 patients with active kidney transplant was selected. As an additional control group, 12 healthy volunteers were recruited. Nailfold videocapillaroscopy was performed in all participants. Additionally, serum concentrations of vascular endothelial growth factor (VEGF) were measured. Results: Videocapillaroscopic e…

The normal circadian pattern of blood pressure: implications for treatment

2004

Blood pressure fluctuates over 24 h following a circadian rhythm that reaches a peak in the morning shortly after awakening. The onset of many acute cardiovascular and cerebrovascular events shows a synchronous cyclical pattern, with the highest incidence of morbidity and mortality in the early morning hours. Strong, although circumstantial, evidence suggests that the early morning surge in blood pressure may contribute to the onset of acute cardiovascular episodes. Sustained blood pressure control that blunts the early morning blood pressure surge may help to reduce the incidence of these events. Antihypertensive agents are needed that provide smooth and sustained blood pressure control fo…