Search results for "ONCE"
showing 10 items of 4997 documents
Muscle conduction velocity, strength, neural activity, and morphological changes after eccentric and concentric training
2014
This study compared the effects of concentric and eccentric training on neuromuscular adaptations in young subjects. Twenty-two men and women were assigned to one of two groups: concentric (CON, n = 11) and eccentric (ECC, n = 11) training. Training consisted of 6 weeks of isokinetic exercise, performed twice weekly, starting with two sets of eight repetitions, and progressing to five sets of 10 repetitions. Subjects were tested in strength variables [concentric, eccentric, and isometric peak torque (PT), and rate of force development (RFD)], muscle conduction velocity (CV), neuromuscular activity, vastus lateralis (VL) muscle thickness, and echo intensity as determined by ultrasonography. …
Managing Persistent Hypoxemia: what is new?
2017
Mechanical ventilation is the standard life-support technique for patients with severe acute respiratory failure. However, some patients develop persistent and refractory hypoxemia because their lungs are so severely damaged that they are unable to respond to the application of high inspired oxygen concentration and high levels of positive end-expiratory pressure. In this article, we review current knowledge on managing persistent hypoxemia in patients with injured lungs.
Cholesterol as stabilizer of the oxytocin receptor
2002
AbstractThe function of the oxytocin receptor system is strongly dependent on steroids as demonstrated by several physiological studies. One key element of this dependence on steroids may be the interaction of cholesterol and the oxytocin receptor. In this study, we show that cholesterol stabilizes the solubilized human oxytocin receptor against thermal inactivation and proteolytic degradation. In the absence of additional cholesterol, the soluble receptor inactivates within minutes. Maximal stabilization of the oxytocin receptor requires a continuous supply with cholesterol from a cholesterol-rich environment. A structure–activity analysis of various cholesterol analogues and their effect …
Differences in myoelectric activity of the lumbar muscles between recurrent and chronic low back pain: a cross-sectional study
2021
Abstract Background Altered lower back muscle activity is proposed as a contributing factor to the reoccurrence and chronicity of low back pain (LBP). This study compared lumbar muscle activity during trunk extension in patients with continuous chronic LBP (CLBP), non-continuous CLBP, recurrent LBP (RLBP) and healthy subjects. Methods In 75 subjects (16 continuous CLBP, 15 non-continuous CLBP, 23 RLBP, 21 healthy controls), surface electromyographic (EMG) activity of the lumbar erector spinae (ES), multifidus (MF), latissimus dorsi (LD) and gluteus maximus (GM) was recorded during the concentric, holding and eccentric phase of a modified Biering Sorenson exercise. Results Continuous CLBP pa…
Unusual oxygen binding behavior of a 24-meric crustacean hemocyanin.
2009
Abstract Hemocyanins from Crustacea usually are found as 1 × 6 or 2 × 6-meric assemblies. An exception is the hemocyanin isolated from thalassinidean shrimps where the main component is a 24-meric structure. Our analysis of oxygen binding data of the thalassinidean shrimp Upogebia pusilla based on a three-state MWC-model revealed that despite the 24-meric structure the functional properties can be described very well based on the hexamer as allosteric unit. In contrast to the hemocyanins from other thalassinidean shrimps the oxygen affinity of hemocyanin from U. pusilla is increased upon addition of l -lactate. A particular feature of this hemocyanin seems to be that l -lactate already enha…
Use of a three-factor interpretive optimisation strategy in the development of an isocratic chromatographic procedure for the screening of diuretics …
2000
Screening of diuretics in urine is feasible through direct injection of the samples into the chromatographic system and isocratic reversed-phase liquid chromatography (RPLC) with micellar-organic mobile phases of sodium dodecyl sulfate (SDS) and 1-propanol. The surfactant coverage of the chromatographic column makes the addition of organic competing amines less necessary than in conventional aqueous-organic RPLC to achieve well-shaped peaks. Also, the range of elution strengths of micellar mobile phases required to elute mixtures of hydrophobic and hydrophilic diuretics is smaller. This allows the isocratic separation of the diuretics within adequate analysis times. An interpretive methodol…
A hyaluronic acid/cyclodextrin based injectable hydrogel for local doxorubicin delivery to solid tumors
2020
Localized delivery of anticancer drugs is often the most useful therapeutic approach for the treatment of solid tumors. The use of injectable polymeric systems that maximize drug concentration in the proximal area of the tumor represents an extremely advantageous therapeutic strategy. Here, the development of an injectable in situ forming hydrogel was accomplished by exploiting the azo-type Michael reaction between an amine derivative of hyaluronic and vinylsulfone functionalized -cyclodextrins complexing doxorubicin. This injectable system can be easily prepared and administered with timelines compatible with normal operating room procedures, as demonstrated by rheological tests. In vitro…
Metaforas par Eiropas Savienību laikrakstā "Diena" no 2015. gada 1. janvāra līdz 30. jūnijam Latvijas prezidentūras Eiropas Savienības Padomē laikā.
2016
Maģistra darbā ir pētītas metaforas par Eiropas Savienību laikrakstā “Diena” no 2015. gada 1.janvāra līdz 30. jūnijam – Latvijas prezidentūras Eiropas Savienības padomē laikā, nolūkā izzināt metaforu lietojuma praksi drukātajā medijā un biežāk sastopamos metaforu izmantojuma gadījumus un īpatnības. Darba teorētisko daļu veido Džordža Leikofa (George Lakoff) radītās konceptuālās metaforu teorijas apskats, un citu autoru, kuru pētījumu objekts ir metafora, iebildumi Leikofa teorijai. Pētījuma lauka analizēšanai ir izmantota viena no biežāk lietotajām drukāto mediju satura izpētes metodēm – kontentanalīze. Kā atbalstošas metodes ir izmantotas pieņemamības sprieduma un brīvā apraksta metodes no…
Psicologia de la Memòria. Quadern de Pràctiques
2014
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. El cuaderno de prácticas de Psicología de la Memoria tiene como objetivos ilustrar a partir de ocho actividades, dirigidas y prácticas, algunos de los principales fundamentos teóricos de la Psicología de la Memoria, y ayudar a los estudiantes a familiarizarse con los procedimientos utilizados en la investigación básica de esta disciplina. En la 1ª actividad, se invita al alumno a reflexionar en torno al concepto de memoria y su complejidad y se complementa con una propuesta de trabajo con una de las pruebas conductuales utilizadas actualmente para la e…
Nie ma takiej wiedzy, która jest ostateczna. Każda stanowi przedsionek prowadzący do nowych obszarów niewiedzy. "Götz i Meyer" Davida Albahariego
2018
This article’s aim is to analyze David Albahari’s Götz and Meyer as the only Serbian literary text whose main theme is the extermination of the native Jews. The recurring key-word of the analysis is the notion of void, which appears both on the plot level and a more metaphorical one that connotes a less perceptible meaning of Albahari’s prose which can be summarized as a conviction about the insufficient memory of the Holocaust in Serbia. The main aim of this paper is to demonstrate what method Albahari employs to build his story. Consequently, juxtaposing history (ostensibly objective, linked with the order of reason) with fiction proves to be here of the utmost importance. It demonstrates…