Search results for "OPRA"
showing 10 items of 283 documents
Ion-exchange fibers and drugs: an equilibrium study
2001
The purpose of this study was to investigate the mechanisms of drug binding into and drug release from cation-exchange fibers in vitro under equilibrium conditions. Ion-exchange groups of the fibers were weakly drug binding carboxylic acid groups (-COOH), strongly drug binding sulphonic acid groups (-SO(3)H), or combinations thereof. Parameters determining the drug absorption and drug release properties of the fibers were: (i) the lipophilicity of the drug (tacrine and propranolol are lipophilic compounds, nadolol is a relatively hydrophilic molecule), (ii) the ion-exchange capacity of the fibers, which was increased by activating the cation-exchange groups with NaOH, (iii) the ionic streng…
Allium kyrenium (Amaryllidaceae), a new species from Northern Cyprus.
2015
Allium kyrenium, a new species of Allium sect. Codonoprasum, is described and illustrated from northern Cyprus. It is a very circumscribed geophyte growing on the calcareous cliffs of the Kyrenia range. This diploid species, with a somatic chromosome number 2n = 16, shows close morphological relationships with A. stamineum, a species complex distributed in the eastern Mediterranean area. Its morphology, karyology, leaf anatomy, ecology, conservation status and taxonomical relationships with the allied species belonging to the A. stamineum group are examined.
Mafia e costi psichici. Le ricadute nei familiari delle vittime di omicidio
La letteratura mostra che la morte di un familiare a causa di un omicidio rappresenta una perdita traumatica in grado di provocare un elevato distress (caratterizzato dal “sinergismo” di trauma e lutto) associato all’aumento del rischio di gravi conseguenze sia sulla salute psichica che sulla qualità della vita in generale (Green, 2000; Rynearson & McCreery, 1993). Recenti reviews (van Denderen et al., 2013; Connolly & Gordon, 2014) hanno messo in evidenza un’elevata incidenza di problematiche psicologiche a medio e a lungo termine nei familiari definiti dalla letteratura “ survivors” (Hertz et al., 2005). Tuttavia, ancora pochi sono gli studi sistematici sulle esperienze di lutto traumatic…
L’influenza del governo della dimensione socio-politica sulla sopravvivenza e sviluppo delle aziende
2010
This paper analysis the socio-political dimension of the firm, focusing the attention on how it affects the survival and development of the firm. In particular, the article emphasizes that in some conditions the management of the socio-political dimension is a necessity to the firm, whereas in other is a discretionary choice due to a particular conception of development.
Kardiopulmonale Parameter bei Hyperthyreose
1999
Background Hyperthyroid patients often suffer from impaired exercise capacity with dyspnoea. Two well established, non-invasive methods were used to evaluate the influence of hyperthyroidism on cardiopulmonary function. Patients and methods In 42 patients with hyperthyroidism we performed spirometry and cardiopulmonary exercise testing before and after 7 days of propranolol therapy as well as in euthyroidism. Results In hyperthyroidism reduced vital capacity and 1-second capacity were observed (95.5 +/- 2.4% vs 102.6 +/- 1.5%; p = 0.0087; 89.4 +/- 2.3% vs 95.2 +/- 2.2%; p = 0.0179). No changes showed during beta-blockade. At the anaerobic threshold reduced tidal volume and enhanced respirat…
Związek metropolitalny jako forma związku publicznoprawnego
2021
Od wielu lat poszukuje się formy prawnej właściwej dla zarządzania obszarami silnie zurbanizowanymi, obejmującymi wielomiejskie tereny o skomplikowanych układach społecznych, gospodarczych, komunikacyjnych oraz administracyjnych. Związek metropolitalny w województwie śląskim funkcjonuje czwarty rok. Także inne duże miasta wraz z gminami sąsiadującymi oczekują objęcia zbliżoną formą organizacji w celu realizacji zadań publicznych. Wśród wielu pytań pojawia się takie: czym jest związek metropolitalny w sensie prawnym? Niniejszy artykuł jest próbą sprawdzenia, na ile koncepcja Tadeusza Bigi z 1928 roku jest aktualna i czy może służyć jako pewien model teoretycznoprawny. Cechami związku publicz…
Topiramate in migraine prophylaxis
2006
Many of the drugs available for the prophylaxis of migraine never underwent rigorous placebo-controlled trials, and the effective drugs have side effects that are problematic in daily practice. Three double-blind studies involving more than 1500 patients (the largest clinical development program ever undertaken for migraine prophylaxis) consistently found topiramate, at doses of 100 and 200 mg/day, to be superior to placebo in migraine prophylaxis. Topiramate has demonstrated efficacy in reducing the frequency of migraines, producing a statistically significant effect at 1 month and maintaining effectiveness over more than 6 months. It is not associated with the side effects that may cause…
Vertical distribution of pharmaceuticals in lake sediments-citalopram as potential chemomarker
2012
The use of pharmaceuticals has increased enormously over the last few decades and serious concerns about their environmental fate and effects have arisen. Thus far, there is little knowledge about the historical pollution of the environment by pharmaceuticals. In the present study, sediment columns from three lake sites adjacent to wastewater treatment plants were collected, further divided in 2- or 2.5-cm slices, and analyzed for 15 pharmaceuticals by liquid chromatography-tandem mass spectrometry. In addition, sediment columns were historically interpreted by analyzing fecal sterols (coprostanol and cholesterol) as well as organic material and organic carbon. Several pharmaceuticals were …
El Teatro Principal de Valencia durante la temporada teatral 1875-1876
2021
El presente artículo revisa toda la actuación operística que hubo en Valencia durante la temporada de 1875 a 1876, la primera que coincide con la restauración de la monarquía de Alfonso XII. A través de la actividad que se produjo en el Teatro Principal de Valencia, examinamos toda la labor operística que hubo en esta ciudad, ya que fue el único lugar donde se representó ópera en Valencia. Una temporada marcada, sin duda alguna, por el estreno de la obra de Verdi, Aida. Un debut que fue posible gracias a la participación del tenor asturiano Lorenzo Abruñedo. Señalamos, asimismo, la importante presencia de la soprano Anna Romilda Pantaleoni, una de las cantantes más sobresalientes en aquel m…
Effects of deep cervical flexor training on pressure pain thresholds over myofascial trigger points in patients with chronic neck pain.
2012
The purpose of this study was to assess the effects of a low-load training program for the deep cervical flexors (DCFs) on pain, disability, and pressure pain threshold (PPT) over cervical myofascial trigger points (MTrPs) in patients with chronic neck pain.Thirty patients with chronic idiopathic neck pain participated in a 6-week program of specific training for the DCF, which consisted of active craniocervical flexion performed twice per day (10-20 minutes) for the duration of the trial. Perceived pain and disability (Neck Disability Index, 0-50) and PPT over MTrPs of the upper trapezius, levator scapulae, and splenius capitis muscles were measured at the beginning and end of the training…