Search results for "ORAL CANCER"
showing 10 items of 100 documents
Estudio de calidad de vida en pacientes diagnosticados de carcinoma epidermoide de mucosa oral, estadios I-IV, intervenidos en el Servicio de Cirugía…
2018
Los tumores de la cavidad oral corresponden al 3% de todos los tumores a nivel mundial. En la actualidad, se tiende a valorar la calidad de los tratamientos que aplicamos a los pacientes con cáncer, en función de la supervivencia, tiempo libre de enfermedad y calidad de vida. Por ello debemos intentar aproximar en la medida de lo posible, la calidad de vida de estos pacientes a la esperable en un estado de salud. Nuestra hipótesis es que la calidad de vida de los pacientes con carcinoma epidermoide de la mucosa oral presenta una importante afectación desde el mismo momento en que reciben el diagnostico. Entendemos que determinadas circunstancias como el estadio tumoral, los tratamientos rec…
Prevalence of aphthous stomatitis in patients with inflammatory bowel disease after the treatment with monoclonal antibodies: a systematic review and…
2022
Currently, the most frequently employed therapies in the treatment of inflammatory bowel diseases (IBD), i.e., Crohn's Disease (CD), Ulcerative Colitis (UC) or unclassified IBD (IBD-U) are monoclonal anti-TNFs and anti-integrin therapies, such as vedolizumab (VDZ). Forty-seven per cent of these patients present extra-intestinal manifestations, the second most prevalent being aphthous stomatitis (AS). The present study aims to investigate which of the two therapies is associated with a lower prevalence of AS after treatment. An electronic search of the MEDLINE (via PubMed), Web of Science, SCOPUS, LILACS and OpenGrey databases was carried out. The criteria used were those described by the PR…
Commonalities between ENT Specialists and Oral Medicine Experts: Old HPV Diseases and New Oral HPV-Cancer along the Borders
2021
A human papillomavirus (HPV) infection is globally one of the most common causes of sexually transmitted infections of the mucous membranes (genital, anal and oral). Over the last decade, an increasing number of young patients have been infected due to the changes in sexual habits in the general population. The majority of the lesions are benign; however, substantial scientific evidence has suggested a role for the HPV family in the carcinogenesis of squamous cell carcinoma (SCC). It is proposed that dentists, in addition to ENT specialists, should apply standardized management protocols in order to construct a well-defined pathway in terms of diagnosis, which is based on a PCR diagnostic t…
A histological and clinical study on oral cancer: Descriptive analyses of 365 cases
2007
Cancer is the second cause of death in Portugal right after cardio vascular diseases. In Portugal the incidence of oral and pharynx cancer (OPC) is higher than uterus and larynx cancers, and in US its frequency is higher than melanoma or uterus cancer, diseases that concern more population than oral cancer. Aims The aim of this paper is to identify preferable anatomic location for oral cancer, mean age of patients, the use of tobacco and alcohol, histological characteristics, staging, type of therapeutics, presence of metastases and 1 and 5 year follow up. Matherials and Methods Data was collected from clinical charts of 365 cases from the Centro de Lisboa do Instituto Português de Oncologi…
DNA integrity in diagnosis of premalignant lesions
2020
Background Carcinogenesis is a dynamic process which traditional biopsying can not keep up with. Saliva as fluid in the vicinity of the tumor can offer better insights to this process. This study aimed to identify the accuracy of salivary DNA integrity index in differentiating between oral premalignant lesions and oral cancer. Material and Methods This phase II diagnostic test accuracy study included 93 patients divided into three groups: 30 oral cancer patients, 33 patients with oral premalignant lesions divided into 21 oral lichen planus patients and 12 patients with leukoplakia and 30 normal individuals who acted as controls. Oral rinse was collected from all participants and they all un…
Cavernous sinus metastasis from oropharyngeal squamous cell carcinoma.
2007
Metastasis to the cavernous sinus from head and neck cancer is uncommon and has been previously reported by a few authors. It is usually a late manifestation of the primary tumor and may be the first evidence of a widespread dissemination of the disease. Main clinical findings are those related with involvement of cranial nerves III to VI as they pass through the cavernous sinus. Although diagnosis may be difficult, the appearance of clinical and radiological findings of cavernous sinus involvement in a context of head and neck cancer must alert us about an intracranial metastatic infiltration. In most cases treatment is palliative with radiotherapy and/or chemotherapy. The prognosis of thi…
The matrix metalloproteinase and insulin-like growth factor system in oral cancer : a prospective clinical study
2017
Aim The absence of reliable single serum biomarkers for oral premalignant lesion (OPL) and oral squamous cell carcinoma (OSCC) limits early diagnosis, monitoring of advanced disease, and prediction of prognosis. Methods In this prospective study, serum levels of matrix metalloproteinase (MMP)-2, MMP-3, MMP-13, insulin-like growth factor (IGF)-1, and IGF-binding protein (IGFBP)-3 were measured in 81 untreated OSCC patients, 49 healthy subjects, and 75 individuals with OPLs, and correlated with clinicopathological parameters. Results Serum levels of MMP-3 were significantly higher in OSCC patients compared to healthy subjects (p=0.004). Mean IGF-1 and IGFBP-3 levels in OSCC patients were sign…
Inflammatory response elements, glycan, and proteome profiles as salivary biomarkers for the early diagnosis of OSCC
2021
El cáncer oral, sobre todo el, carcinoma oral de células escamosas (COCE), es la neoplasia maligna más común en la cavidad oral que se caracteriza por un mal pronóstico y una baja tasa de supervivencia, cuando se diagnostica en estadios avanzados. Puede ser tratado de forma efectiva si se detecta en estadios iniciales, mejorando el pronóstico. Por tanto, tras la prevención, el diagnóstico precoz se ha convertido en el principal objetivo en el manejo del cáncer oral, dado su impacto positivo en la supervivencia y calidad de vida de estos pacientes. A menudo, los escasos síntomas iniciales pasan desapercibidos y la enfermedad se descubre en fases avanzadas, por lo que se requiere mejorar el d…
The matrix metalloproteinase and insulin-like growth factor system in oral cancer – a prospective clinical study
2017
Eik Schiegnitz,1 Peer W Kämmerer,2 Holger Schön,1 Christoph Gülle,1 Manfred Berres,3,4 Keyvan Sagheb,1 Bilal Al-Nawas5 1Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, 2Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre Rostock, Rostock, 3Department of Mathematics and Technology, University of Applied Sciences Koblenz, Remagen, 4Institute of Medical Biometry, Epidemiology and Informatics, Johannes Gutenberg University of Mainz, Mainz, 5Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre, Martin-Luther University Ha…