Search results for "ORATOR"
showing 10 items of 1840 documents
Mycotoxin contamination in laboratory rat feeds and their implications in animal research
2016
Compound feed is particularly vulnerable to multi-mycotoxin contamination. A method for the determination of 12 mycotoxins; enniatins A, A1, B, B1; aflatoxins B1, B2, G1, G2; OTA; ZEA; T-2 and HT-2 by liquid chromatography-tandem mass spectrometry has been developed and applied for the analysis of laboratory rat commercial feeds. The method trueness was checked by recovery assays at three different spiked levels (n = 9). Recoveries ranged from 73% to 112%, and the intra-day and inter-day precision were lower than 9% and 13%, respectively. Limits of quantitation were lower than 15 μg/kg. Twenty-seven laboratory rats feed samples showed multi-contamination by at least three up to six differen…
Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals
2011
Abstract Allergic contact dermatitis is induced by repeated skin contact with an allergen. Assessment of the skin sensitizing potential of chemicals, agrochemicals, and especially cosmetic ingredients is currently performed with the use of animals. Animal welfare and EU legislation demand animal-free alternatives reflected in a testing and marketing ban for cosmetic ingredients beginning in 2013. The underlying mechanisms of induction and elicitation of skin sensitization are complex and a chemical needs to comply several properties being skin sensitizing. To account for the multitude of events in the induction of skin sensitization an in vitro test system will consist of a battery of vario…
Human Hepatic Cell Cultures: In Vitro and In Vivo Drug Metabolism
2003
Drug metabolism is the major determinant of drug clearance, and the factor most frequently responsible for inter-individual differences in drug pharmacokinetics. The expression of drug metabolising enzymes shows significant interspecies differences, and variability among human individuals (polymorphic or inducible enzymes) makes the accurate prediction of the metabolism of a new compound in humans difficult. Several key issues need to be addressed at the early stages of drug development to improve drug candidate selection: a) how fast the compound will be metabolised; b) what metabolites will be formed (metabolic profile); c) which enzymes are involved and to what extent; and d) whether dr…
Diversity and Evolution of the Phenazine Biosynthesis Pathway
2010
ABSTRACT Phenazines are versatile secondary metabolites of bacterial origin that function in biological control of plant pathogens and contribute to the ecological fitness and pathogenicity of the producing strains. In this study, we employed a collection of 94 strains having various geographic, environmental, and clinical origins to study the distribution and evolution of phenazine genes in members of the genera Pseudomonas , Burkholderia , Pectobacterium , Brevibacterium , and Streptomyces . Our results confirmed the diversity of phenazine producers and revealed that most of them appear to be soil-dwelling and/or plant-associated species. Genome analyses and comparisons of phylogenies inf…
Early results of a low-profile stent-graft for thoracic endovascular aortic repair
2020
Purpose To assess outcomes of a low-profile thoracic stent-graft in the treatment of thoracic aortic pathologies. Methods A retrospective analysis of all consecutive patients with aortic thoracic pathologies treated with the RelayPro device in two university hospitals between October 2018 and July 2019. Results 23 patients (65% men; mean age 63.4 ± 15 years) were treated. Pathologies included aortic dissections (n = 10), 5 residual type A (22%) and 5 type B (22%), 6 degenerative aortic aneurysms (26%), 4 penetrating aortic ulcers (17%), and aortic erosion, intramural hematoma and aortic rupture (n = 1 and 4% in each case). Two cases (9%) were emergent and two urgent. Proximal landing was a…
Photocatalytic ozonation for a sustainable aquaculture: A long-term test in a seawater aquarium
2019
Abstract A long-term test at a laboratory scale with a closed system (a coral reef aquarium) has been carried out to study the potentialities of photocatalytic ozonation and photocatalysis for the removal of noxious organic compounds in recirculating systems (aquaria and recirculating aquaculture systems) working with a minimum make up of new water. Attention has been focused not only on the depuration capabilities but also on possible negative phenomena, some of which could become apparent only at long times. After having tuned the system by setting appropriate operating conditions and procedures, positive results were obtained. In particular, it was observed that the alternation of photoc…
An anthropic soil transformation fingerprinted by REY patterns
2009
Abstract This Focus article deals intentionally with modern soil disturbance in situ . This is of interest to archaeologists as after disturbances, both short- and long-term, pedogenesis (re-)starts obliterating previous signs. Soil modifications induced by human activity may be linked to pedogenetic evidence for disturbance with archaeological evidence for the cultural activities. We contrasted two 750-m 3 soil pedons, an Anthrosol and a Kastanozem, from which the Anthrosol is derived, using 77 descriptors of soil properties which have been utilized in archaeological studies (pedo-morphological, routine laboratory, biochemical, metals and rare earth elements plus yttrium, REY) with the aim…
A laboratory cave for the study of wall degradation in rock art caves : an implementation in the Vézère area
2013
The aim of this proposal is to present an original approach to the study and preservation of rock art caves. A multidisciplinary study of cave wall alteration will be performed to understand the impact of environmental context on the evolution of wall surfaces. The approach involves the choice of a cave with characteristics similar to painted caves in the studied area (Vézère Valley in Dordogne, France): e.g., cave wall alteration, lithology, morphology, etc. This selected cave is intended to become a laboratory cave, monitored for the acquisition of chemical, physical and biological environmental data on bedrock, air and fluids along with their characteristics. A cave without art or archae…
Imparare dall'architettura
2022
Il Laboratorio di progettazione architettonica della prima annualità si rivolge ad allievi che, per quanto non abbiano alcuna esperienza sulla pratica del progetto, sono chiamati, da subito, a confrontarsi con il fare progettuale, e ciò a differenza di quanto, in genere, accade in altri ambiti di apprendimento dell’esercizio di professioni specialistiche come quella dell’architetto. L’incipit, ovvero l’inizio, l’azione dell’incipĕre rappresenta, quindi, l’avvio, il principio, l’incominciare di un percorso formativo in cui tutti, benché neofiti, sono chiamati a un’immediata e iniziale frequenza del “saper fare” riguardo alla progettazione architettonica. E se il divenire dell’architettura, a…
INCIPIT LAB
2022
Il libro descrive un’esperienza didattica condotta dall’anno accademico 2015/2016 al 2017/2018 e segna l’avvio del coordinamento di Incipit Lab. Tale iniziativa ha offerto un confronto, a livello nazionale e internazionale, fra i laboratori di progettazione architettonica del primo anno accademico. La sperimentazione effettuata trova la sua origine nel coordinamento dei laboratori di primo anno del Corso di Studi in Architettura dell’Università degli Studi di Palermo con il coinvolgimento, inoltre, del Laboratorio di Architettura e Composizione I del Corso di Studi in Ingegneria Edile-Architettura, dello stesso Ateneo. Incipit Lab. propone, attraverso un coordinamento, giunto al suo sesto a…