Search results for "ORC"
showing 10 items of 4623 documents
Rationale and design of dal-VESSEL: a study to assess the safety and efficacy of dalcetrapib on endothelial function using brachial artery flow-media…
2011
Dalcetrapib increases high-density lipoprotein cholesterol (HDL-C) levels through effects on cholesteryl ester transfer protein (CETP). As part of the dalcetrapib dal-HEART clinical trial programme, the efficacy and safety of dalcetrapib is assessed in coronary heart disease (CHD) patients in the dal-VESSEL study (ClinicalTrials.gov identifier: NCT00655538), the design and methods of which are presented here. RESEARCH DESIGN AND STUDY METHOD: Men and women with CHD or CHD risk equivalent, with HDL-C levels50 mg/dL were recruited for a 36-week, double-blinded, placebo-controlled trial. After a pre-randomisation phase of up to 8 weeks, patients received dalcetrapib 600 mg/day or placebo in …
Combination of omalizumab and specific immunotherapy is superior to immunotherapy in patients with seasonal allergic rhinoconjunctivitis and co-morbi…
2008
Summary Background The treatment of allergic asthma by specific immunotherapy (SIT) is hampered by potential side-effects. Objective The aim of this study was to study the effect of omalizumab, a monoclonal anti-IgE antibody, in combination with SIT in patients with seasonal allergic rhinoconjunctivitis (SAR) and co-morbid seasonal allergic asthma (SAA) incompletely controlled by conventional pharmacotherapy. Methods A randomized, double-blind, placebo-controlled, multi-centre trial was performed to assess the efficacy and safety of omalizumab (Xolair®) vs. placebo in combination with depigmented SIT (Depigoid®) during the grass pollen season. Omalizumab or placebo was started 2 weeks befor…
Higher leisure-time physical activity is associated with lower sickness absence: cross-sectional analysis among the general workforce
2020
BACKGROUND: Prevention of sickness absence (SA) is a major public health challenge. Sufficient levels of physical activity may be an important protective factor. In contrast to the North European countries, little is known about physical activity behavior and its influence over SA in South European countries. METHODS: In the European Health Interview Survey (EHIS) 2014, a total of 9512 Spanish workers aged 17 to 70 (46.5% women) replied to questions about SA (last 12 months) and the frequency of leisure-time physical activity (LTPA). Multiple linear regression adjusted for age, sex, education, occupational class, smoking habits, body mass index, and chronic disease (diabetes, hypertension, …
Biomechanical factors affecting running economy.
2001
KYROLAINEN, H., A. BELLI, and P. V. KOMI. Biomechanical factors affecting running economy. Med. Sci. Sports Exerc., Vol. 33, No. 8, 2001, pp. 1330 -1337. Purpose: The present study was designed to investigate kinematics, kinetics, and muscle activity for explaining running economy at different running speeds. Methods: A total of 17 young endurance runners ran at 12-13 different running speeds. Respiratory gases were collected. Kinematic records were obtained by a high-speed video camera, and 3-D ground reaction forces (GRF) were measured simultaneously with telemetric EMG recordings of the selected leg muscles. In the analysis, joint moments and power were calculated by inverse dynamic meth…
Biomechanical and skeletal muscle determinants of maximum running speed with aging.
2009
Purpose: Aging diminishes the ability to run fast, but the specific mechanisms responsible for this deterioration remain largely unknown. In the present study, we investigated the age-related decline in sprint running ability through a cross-sectional examination of biomechanical and skeletal muscle characteristics in 77 competitive male sprinters aged 17-82 yr. Methods: Ground reaction force (GRF) and kinematic stride cycle parameters were measured during the maximum-velocity phase using a 9.4-m-long force platform. Knee extensor (KE) and ankle plantar flexor (PF) structural characteristics were investigated using ultrasonography and muscle biopsies (vastus lateralis). Force production cha…
The influence of ageing on the force-velocity-power characteristics of human elbow flexor muscles.
2003
Abstract The purpose of this study was to quantify the effects of ageing on the maximal power ( P max ) of the elbow flexor muscles and to determine the impact of velocity on the loss of power in older people. Sixteen elderly subjects (7 men and 9 women, age range 61–78 years) and 17 young subjects (11 men and 6 women, age range 18–27 years) participated in this study. Maximal elbow flexions were performed against increasing inertia. The maximal force ( F max ), maximal shortening velocity ( V max ), P max , dynamic constants ( a , b and a / F max ), optimal force ( F opt ), optimal velocity ( V opt ) and V opt / V max were determined from Hill's equation. Myoelectrical activity (EMG) of th…
Muscle activation during cycling at different cadences: Effect of maximal strength capacity
2007
International audience; The purpose of this study was to examine the influence of maximal strength capacity on muscle activation, during cycling, at three selected cadences: a low cadence (50 rpm), a high cadence (110 rpm) and the freely chosen cadence (FCC). Two groups of trained cyclists were selected on the basis of the different maximal isokinetic voluntary contraction values (MVCi) of their lower extremity muscles as follow: Fmin (lower MVCi group) and Fmax (higher MVCi group). All subjects performed three 4-min cycling exercises at a power output corresponding to 80 % of the ventilatory threshold under the three cadences. Neuromuscular activity of vastus lateralis (VL), rectus femoris…
Haemodynamic effects of a single intravenous dose of lorcainide in patients with heart disease
1980
The cardiovascular effects of a single i.v. dose (2 mg/kg over 5 min) of lorcainide were studied in 14 patients with heart disease. In the haemodynamic part of the study (6 patients), the aortic and pulmonary systolic, diastolic and mean pressures, left ventricular systolic and end-diastolic pressures, cardiac output and the rate of rise of left ventricular pressure were measured before and for 30 min after administration of the drug. Lorcainide produced a slight and short-lasting decrease in the aortic and pulmonary systolic pressures, and all other pressure values remained unchanged. The cardiac output and systemic vascular resistance were not altered by lorcainide. It consistently depres…
Acute stress impairs reward positivity effect in probabilistic learning
2019
Decision making based on feedback learning requires a series of cognitive processes, including estimating the probability of particular outcomes and modulating expectations between expected versus actual outcomes. It has been suggested that stress affects decision making and subsequent processing of feedback valence and magnitude. However, less is known about the effect of acute stress on reward expectancy. In the current study, participants performed a probabilistic learning task, in which they learned an association between response and feedback within different reward expectancy trials (30% and 70%) under the conditions of stress (threat of shock) and safety (no shock). We recorded event…
Non-classic cystic fibrosis associated with D1152HCFTR mutation
2010
Burgel P-R, Fajac I, Hubert D, Grenet D, Stremler N, Roussey M, Siret D, Languepin J, Mely L, Fanton A, Labbe A, Domblides P, Vic P, Dagorne M, Reynaud-Gaubert M, Counil F, Varaigne F, Bienvenu T, Bellis G, Dusser D. Non-classic cystic fibrosis associated with D1152H CFTR mutation. Background: Limited knowledge exists on phenotypes associated with the D1152H cystic fibrosis transmembrane conductance regulator (CFTR) mutation. Methods: Subjects with a D1152H allele in trans with another CFTR mutation were identified using the French Cystic Fibrosis Registry. Phenotypic characteristics were compared with those of pancreatic insufficient (PI) and pancreatic sufficient (PS) cystic fibrosis (CF)…