Search results for "OSTEOARTHRITIS"
showing 10 items of 345 documents
GASTRO-ESOPHAGEAL REFLUX MANIFESTATIONS IN THE TREATMENT OF OSTEOARTHRITIS WITH NON STEROIDAL ANTI-INFLAMMATORY DRUGS
2008
Intra-Articular Hybrid Hyaluronic Acid Injection Treatment in Overweight Patients with Knee Osteoarthritis: A Single-Center, Open-Label, Prospective …
2021
Background: A BMI >
Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E2 production in osteoarthritic chondrocytes
2009
Pro-inflammatory cytokines such as interleukin-1beta (IL-1beta) may participate in the pathogenesis of cartilage damage in osteoarthritis (OA) through the production of catabolic enzymes and inflammatory mediators. Induction of heme oxygenase-1 (HO-1) has previously been shown to exert anti-inflammatory effects in different cell types. We have investigated whether HO-1 induction may modify chondrocyte viability and the production of relevant mediators such as oxidative stress and prostaglandin E(2) (PGE(2)) elicited by IL-1beta in OA chondrocytes. Chondrocytes were isolated from OA cartilage and used in primary culture. Cells were stimulated with IL-1beta in the absence or presence of the H…
Kaulu smadzenu mononukleāro šūnu daudzumuun kvalitātiietekmējošie faktori cela locītavas osteoartrīta pacientiem
2020
Osteoartrīts ir visizplatītākā locītavu slimība ar ievērojamām ekonomiskām izmaksām un pieaugošu izplatību (Conaghan et al. 2014). Viena no galvenajām problēmām ir tā, ka nav nekādas ārstēšanas, izņemot locītavas aizvietošanu, kas var izārstēt osteoartrītu, tāpēc ir svarīgi izpētīt alternatīvas ārstēšanas metodes, piemēram, cilmes šūnu terapiju. Interese par mononukleāro šūnu izpēti kā ārstēšanas metodi ir plaši pieaugusi, bet vēl tikai nedaudz ir zināms par optimālo ievadīto mononukleāro šūnu daudzumu un par to, kāpēc mononukleāro un mezenhimālo cilmes šūnu daudzums un kvalitāte cilvēkiem ir atšķirīga. Pētījuma mērķis ir noskaidrot, vai starp pacientu faktoriem, piemēram, vecumu, dzimumu, …
Effects of exercise on life quality in a rheumatoid arthritis patient
2020
Rheumatoid arthritis (RA) is a chronic-degenerative disease characterized by symptoms that significantly impact on the functional capacity and thus, the ability to carry out daily functional activities reducing the quality of life (QoL). The aim was to evaluate the effects of a strength and conditioning (S&C) program on the quality of life (QoL), the self-perception disease impact, the self-fatigue perception and cardiovascular risk factors in a patient with rheumatoid arthritis (RA) and cardiovascular disease (CVD). 34-year-old woman (height: 1.40m; weight: 36.1kg) diagnosed with RA and CVD underwent a six-month S&C program with aerobic training 2-3 times a week in 1-3 sets of 5-15 minutes…
Oxidative stress in osteoarticular diseases
2016
Effect of chondroitin sulphate and glucosamine in combination in an animal model of osteoarthritis and osteoporosis
2014
Effects of a progressive aquatic resistance exercise program on the biomechanical composition and morphology of cartilage in women with mild knee ost…
2013
Background. Symptoms associated with osteoarthritis of the knee result in decreased function, loss of working capacity and extensive social and medical costs. There is a need to investigate and develop effective interventions to minimise the impact of and even prevent the progression of osteoarthritis. Aquatic exercise has been shown to be effective at reducing the impact of osteoarthritis. The purpose of this article is to describe the rationale, design and intervention of a study investigating the effect of an aquatic resistance exercise intervention on cartilage in postmenopausal women with mild knee osteoarthritis. Methods. A minimum of 80 volunteers who meet the inclusion criteria will…
Multidimensional prognostic index and the risk of fractures: an 8-year longitudinal cohort study in the Osteoarthritis Initiative
2021
Abstract Summary In this longitudinal study, with a follow-up of 8 years, multidimensional prognostic index (MPI), a product of the comprehensive geriatric assessment, significantly predicted the onset of fractures in older people affected by knee osteoarthritis. Purpose Frailty may be associated with higher fracture risk, but limited research has been carried out using a multidimensional approach to frailty assessment and diagnosis. The present research aimed to investigate whether the MPI, based on comprehensive geriatric assessment (CGA), is associated with the risk of fractures in the Osteoarthritis Initiative (OAI) study. Methods Community-dwellers affected by knee OA or at high risk f…