Search results for "OSTEOARTHRITIS"

Hip viscosupplementation under ultra-sound guidance riduces NSAID consumption in symptomatic hip osteoarthritis patients in a long follow-up. Data fr…

2011

Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) consumption is strictly related to a high gastrointestinal and cardiovascular mortality and morbidity rate. Osteoarthritis Research Society International (OARSI) recommendations in patients with symptomatic hip or knee OA stated that NSAIDs should be used at the lowest effective dose but their long-term use should be avoided if possible. OARSI guidelines for the treatment of the hip OA include the use of viscosupplementation, which aims to restore physiological and rheological features of the synovial fluid. Objective: Aim of this multicentric, open and retrospective study is to investigate if NSAID consumption may be reduced by t…

Knee extensor and flexor dominant gait patterns increase the knee frontal plane moment during walking

2013

High gait-induced knee frontal plane moment is linked with the development of knee osteoarthritis. Gait patterns across the normal population exhibit large inter-individual variabilities especially at the knee sagittal plane moment profile during loading response and terminal stance phase. However, the effects of different gait patterns on this moment remain unknown. Therefore, we examined whether different gait patterns are associated with atypically high knee frontal plane moments. Profiles of knee joint moments divided a sample of 24 subjects into three subgroups (11, 7, 6) through cluster analysis. Kinetics, kinematics, and spatio-temporal parameters were compared among clusters. Subjec…

Course of physical functioning and pain in osteoarthritis of the knee or hip: a systematic review

2014

Is time to joint replacement a valid outcome measure in clinical trials of drugs for osteoarthritis?

2003

The rate of radiographic joint space narrowing is commonly used today as a structural outcome measure in clinical trials evaluating potential disease-modifying drugs in patients with hip osteoarthritis, but this results in a continuous variable. Among the methods proposed to circumvent this problem, it has been suggested that the incidence of total hip arthoplasty (THA) provides a hard outcome measure. It is a dichotomized variable, easy to measure and sensitive to change, with acceptable intrinsic validity. However, because this measure is limited by the variability of factors underlying the decision to perform surgery and the length of waiting lists, it has been suggested that time to ful…

AB1076 Course of Physical Functioning and Pain in Osteoarthritis of the Knee or Hip: A Systematic Review

2014

Background The natural course of physical functioning in knee and/or hipOA is highly variable; some patients remain stable, while others improve or worsen. Knowledge on prognostic risk factors related to physical functioning are used to adapt interventions. Objectives (1) To systematically summarize the literature from March 2005 to January 2013 on the course of physical functioning and pain in patients with OA of the knee or hip and (2) to provide an overview of prognostic factors of physical functioning and future pain for these patients. Methods A search was conducted in PubMed, CINAHL, Embase and Psych-INFO in January 2013. Eligible studies were prospective cohort studies that included …

Die Kleinfragment-Doppelplattenosteosynthese bei C1- bis C3-Frakturen des Pilon tibiale

2008

Intra-articular fractures of the tibial pilon always have been a challenge for the surgeon and his operative technique. With conservative or operative management, we have to take care of destroyed articular surfaces and traumatised soft tissues. Therefore, tibial pilon fractures are known in the literature as complicated lesions with a high rate of complications. Between 1993 and 2001 twenty-one patients who were between 18 and 65 years old and suffered a monotrauma of the tibial pilon of the type C1 to C3 of the AO classification, were treated with a staged reconstruction. Stabilisation was done by small-fragment double plate osteosynthesis. In this retrospective study, we could review 17 …

Exercise for bone and cartilage in postmenopausal women with mild knee osteoarthritis

2016

The purpose of this study was to investigate the effects of high-impact exercise on bone mineral mass and strength, and on knee cartilage composition in postmenopausal women with mild knee osteoarthritis (OA). In addition, the association between knee OA and femoral neck bone structural characteristics in women with mild knee radiographic OA and those without radiographic knee OA was studied. Also, the reproducibility of measuring human knee joint cartilage by the delayed gadolinium-enhanced MRI (dGEMRIC) technique was determined in healthy asymptomatic subjects. Data from a 12-month randomized controlled trial (RCT) was used to assess the effects of exercise on bones and cartilages. The tr…

Interactive multiobjective optimization for finding the most preferred exercise therapy modality in knee osteoarthritis

2022

Abstract Background There are no explicit guidelines or tools available to support clinicians in selecting exercise therapy modalities according to the characteristics of individual patients despite the apparent need. Objective This study develops a methodology based on a novel multiobjective optimization model and examines its feasibility as a decision support tool to support healthcare professionals in comparing different modalities and identifying the most preferred one based on a patient’s needs. Methods Thirty-one exercise therapy modalities were considered from 21 randomized controlled trials. A novel interactive multiobjective optimization model was designed to characterize the effic…

Allelic variants of IL1R1 gene associate with severe hand osteoarthritis

2010

Background. In search for genes predisposing to osteoarthritis (OA), several genome wide scans have provided evidence for linkage on 2q. In this study we targeted a 470 kb region on 2q11.2 presenting the locus with most evidence for linkage to severe OA of distal interphalangeal joints (DIP) in our genome wide scan families. Methods. We genotyped 32 single nucleotide polymorphisms (SNPs) in this 470 kb region comprising six genes belonging to the interleukin 1 superfamily and monitored for association with individual SNPs and SNP haplotypes among severe familial hand OA cases (material extended from our previous linkage study; n = 134), unrelated end-stage bilateral primary knee OA cases (n…

Kuntoutuminen lonkan tekonivelleikkauksesta : kuntoutujien kertomat tarinamallit

2012

TIIVISTELMÄ Kuntoutuminen lonkan tekonivelleikkauksesta – kuntoutujien kertomat tarinamallit Knaapi-Junnila Sari Fysioterapian pro gradu-tutkielma. Jyväskylän yliopisto, liikunta- ja terveystieteiden tiedekunta, terveystieteiden laitos, 2012. 167 sivua, 36 liitesivua. Tämä tutkimus on osa Jyväskylän yliopiston johtamaa Osallistava potilasohjaus fysioterapiassa -tutkimushanketta. Tämän osatutkimuksen tavoitteena on ymmärtää kuntoutumisen merkityksiä lonkan tekonivelleikkauksesta kuntoutuville. Tutkimusaineisto koostuu kymmenen, 63–79-vuotiaan kuntoutujan haastatteluista leikkaukseen valmistautuessa ja siitä kuntoutumisen alkuvaiheessa. Tutkimuksessa selvitetään, minkälaisia tarinoita he kert…