Search results for "OSTEOPOROSI"

showing 10 items of 434 documents

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

2014

Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and repli…

MaleOncologyHeelBone densityOsteoporosisGenome-wide association studyCohort StudiesFractures Bonequantitative ultrasoundBone DensityGenetics (clinical)riskUltrasonographyAged 80 and overGeneticsmedicine.diagnostic_testAssociation Studies Articlesphenotypesta3141General MedicineMiddle Aged3. Good healthmedicine.anatomical_structureosteoporosis diagnostic radiologic examination roentgen rays ultrasonography bone mineral density fractures calcaneus chromosomes genes genome heel longevity single nucleotide polymorphism sound genetics chromosome 7q31 genotype determination genome-wide association study attenuation osteoporotic fracture risk/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemalewomenAdultmusculoskeletal diseasesmedicine.medical_specialtyx-ray absorptiometrySingle-nucleotide polymorphismdensitometryBiologyPolymorphism Single NucleotidecalcaneusYoung AdultSDG 3 - Good Health and Well-beingInternal medicineGeneticsmedicineHumansGenetic Predisposition to DiseaseMolecular BiologyDual-energy X-ray absorptiometryVLAGAgedGlobal NutritionWereldvoedingta1184ta3121medicine.diseaseosteoporosisCalcaneusGenetic epidemiologyfractureOsteoporosismineral densityCalcaneusGenome-Wide Association Study
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Bone status in adolescents and young adults with type 1 diabetes: a 10-year longitudinal study

2020

Introduction: This study presents a 10-year longitudinal assessment of bone status in adolescents and young adults with type 1 diabetes (T1D). Material and methods: Thirty-two patients (12 female, aged 20.5 ± 3.93 years, T1D duration 13.9 ± 1.97 years) were studied using quantitative ultrasound (QUS) and dual-energy X-ray absorptiometry (DXA). Standard deviation scores (SDS) for these results were calculated. The following clinical parameters were analysed: sex, age, T1D duration, anthropometric parameters, daily insulin requirement (DIR), mean glycated haemoglobin (HbA1c) in the year preceding the examination, medication other than insulin, history of bone fractures, and comorbidities. Res…

MalePediatricsmedicine.medical_specialtyLongitudinal studyAdolescentEndocrinology Diabetes and Metabolismmedicine.medical_treatmentBone and BonesAnthropometric parametersYoung AdultEndocrinologyAbsorptiometry PhotonBone DensitymedicineHumansReference populationLongitudinal StudiesYoung adultGlycated haemoglobinType 1 diabetesbusiness.industryInsulinmedicine.diseasetype 1 diabetes; glycaemic control; bone status; quantitative ultrasound; dual X-ray absorptiometryQuantitative ultrasoundDiabetes Mellitus Type 1OsteoporosisFemalebusinessEndokrynologia Polska (Polish Journal of Endocrinology)
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A Polymorphism in a Gene Encoding Perilipin 4 Is Associated with Height but not with Bone Measures in Individuals from the Framingham Osteoporosis St…

2011

There is increasing interest in identifying new pathways and candidate genes that confer susceptibility to osteoporosis. There is evidence that adipogenesis and osteogenesis may be related, including a common bone marrow progenitor cell for both adipocytes and osteoblasts. Perilipin 1 (PLIN1) and Perilipin 4 (PLIN4) are members of the PATS family of genes and are involved in lipolysis of intracellular lipid deposits. A previous study reported gender-specific associations between one polymorphism of PLIN1 and bone mineral density (BMD) in a Japanese population. We hypothesized that polymorphisms in PLIN1 and PLIN4 would be associated with bone measures in adult Caucasian participants of the …

MalePerilipin-1medicine.medical_specialtyCandidate geneGenotypeBone densityEndocrinology Diabetes and MetabolismOsteoporosisSingle-nucleotide polymorphismBiologyPerilipin-4Polymorphism Single NucleotideArticleAbsorptiometry PhotonEndocrinologyBone DensityInternal medicinemedicineBone mineral densityHumansSNPGenetic Predisposition to DiseaseOrthopedics and Sports MedicineHuman heightBone mineralBone geometryFramingham Osteoporosis StudyMiddle AgedPhosphoproteinsmedicine.diseaseBody HeightPerilipin 4EndocrinologyPerilipin 1PerilipinOsteoporosisFemaleCarrier Proteins
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Low bone mineral density in HIV-positive young Italians and migrants.

2020

Background Human immunodeficiency virus (HIV) infected individuals may have osteoporosis. We aimed to evaluate the bone mineral density (BMD) in naïve antiretroviral (ARV) treated HIV positive patients comparing native Italian group (ItG) to a Migrants group (MiG) upon arrival in Italy. Methods We conducted a cross-sectional study on 83 HIV patients less than 50 years old. We used the dual-energy X-ray absorptiometry (DXA) within six months from the HIV diagnosis. Participants were categorized as having low BMD if the femoral neck or total lumbar spine Z-score was– 2 or less. Results MiG showed low BMD more often than ItG (37.5% vs.13.6%), especially for the female gender (16.7% vs. 0.0%). …

MaleRNA virusesEuropean PeopleCritical Care and Emergency MedicineBone densityEpidemiologyOsteoporosisHIV InfectionsLogistic regressionPathology and Laboratory Medicine0302 clinical medicineAbsorptiometry PhotonImmunodeficiency VirusesBone DensityMedicine and Health SciencesEthnicities030212 general & internal medicineVitamin DConnective Tissue DiseasesMusculoskeletal SystemTrauma MedicineBone mineralTransients and MigrantsMultidisciplinaryQRvirus diseasesHuman immunodeficiency virus (HIV)HIV diagnosis and managementosteoporosis.Middle AgedItalian Peoplemedicine.anatomical_structureAnti-Retroviral AgentsItalyMedical MicrobiologyConnective TissueBone FractureViral PathogensVirusesMedicineInfectious diseasesFemalePathogensAnatomyTraumatic InjuryResearch ArticleAdultMedical conditionsmedicine.medical_specialtyScience030209 endocrinology & metabolismViral diseasesMicrobiology03 medical and health sciencesLumbarSex FactorsRheumatologyInternal medicineRetrovirusesmedicineVitamin D and neurologyHumansBoneMicrobial PathogensSkeletonFemoral neckbusiness.industryLentivirusOrganismsBiology and Life SciencesHIVBone fracturemedicine.diseaseDiagnostic medicineCD4 Lymphocyte CountCross-Sectional StudiesLogistic ModelsBiological TissueMedical Risk FactorsPeople and PlacesOsteoporosisPopulation GroupingsbusinessPloS one
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Statins, Fracture Risk, and Bone Remodeling: What Is True?

2006

Besides the action on plasma lipid levels, statins show a series of ancillary effects defined as all of their vascular and nonvascular effects independent from the cholesterol reduction. It has been recently hypothesized that one of these ancillary effects could be the improvement of bone health, due to the interference with bone metabolism. This may potentially represent the rationale for statins' use in the treatment of osteoporosis, the most common disease of the bone. Both experimental observations and clinical studies on this topic generated a number of conflicting results; however, the largest randomized clinical trials, the Scandinavian Simvastatin Survival Study (4S), Long Term Inte…

MaleRiskSimvastatinmedicine.medical_specialtyOsteoporosisMyocardial IschemiaBioinformaticsBone remodelinglaw.inventionFractures Bonechemistry.chemical_compoundRandomized controlled trialRisk FactorslawHumansMedicineLongitudinal StudiesRisk factorPravastatinRandomized Controlled Trials as Topicbusiness.industryCholesterolOsteoporosiStatinnutritional and metabolic diseasesGeneral Medicinemedicine.diseaseSurgerychemistrySimvastatinOsteoporosisFemalelipids (amino acids peptides and proteins)Bone RemodelingTherapyHydroxymethylglutaryl-CoA Reductase InhibitorsbusinessFracturesHeart Protection StudyPravastatinmedicine.drugThe American Journal of the Medical Sciences
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Classification of functioning and assessment of fracture risk of a large Italian osteoporotic population. The physiatric approach to osteoporosis pro…

2015

Background: Osteoporosis is a skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. Osteoporotic fractures cause significant morbidity, disability, and decrease in quality of life. Aim: The aims of the Physiatric Approach To Osteoporosis (PATO) project were to classify osteoporotic patients with or without fragility fractures, using the Brief ICF (International Classification of Functioning, Disability and Health) Core Set for Osteoporosis and to calculate the fracture risk with the WHO FRAX® (World Health Organization Fracture Risk Assessment Tool) algorithm. Design: Cross-sectional survey. Setting: Seventy-nine Italian Rehabilitation S…

MaleSettore MED/34 - Medicina Fisica E RiabilitativaRehabilitationOsteoporosiRisk Assessmentosteoporosis rehabilitation fractureDisability EvaluationFractureCross-Sectional StudiesItalyBone DensityRisk FactorsSurveys and QuestionnairesHumansOsteoporosisFemaleBoneAlgorithmsOsteoporotic FracturesAgedDemographyPain Measurement
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Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study

2017

Objectives: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients. Subjects and Methods: Retrospective analysis of data from 22 secondary care centres in seven countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012. Results: The median (95%CI) TTO was 6.0 years in patients treated with alendronate (n = 88) and 2.2 years in those treated with zoledronate (n = 218). Multiv…

MalebisphosphonateTime Factorsmedicine.medical_treatmentOsteoporosis0302 clinical medicineRisk Factors80 and overosteoporosijaw osteonecrosiAged 80 and overBone Density Conservation AgentsDiphosphonatesjaw osteonecrosisjaw osteonecrosis bisphosphonates breast cancer multiple myeloma prostate cance osteoporosisIncidenceIncidence (epidemiology)Otorhinolaryngology2734 Pathology and Forensic MedicineMiddle Agedprostate cancermultiple myeloma030220 oncology & carcinogenesisBisphosphonate-Associated Osteonecrosis of the JawFemaleAdultmedicine.medical_specialty2734Drug Administration SchedulePathology and Forensic Medicine03 medical and health sciencesbreast cancerbisphosphonates; breast cancer; jaw osteonecrosis; multiple myeloma; osteoporosis; prostate cancer; Adult; Aged; Aged 80 and over; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Cross-Sectional Studies; Diphosphonates; Drug Administration Schedule; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Retrospective Studies; Risk Factors; Time Factors; Otorhinolaryngology; 2734; Pathology and Forensic Medicine; Dentistry (all)Internal medicinemedicineHumansBisphosphonates; Breast cancer; Jaw osteonecrosis; Multiple myeloma; Osteoporosis; Prostate cancer; Otorhinolaryngology2734 Pathology and Forensic Medicine; Dentistry (all)prostate canceAdverse effectGeneral DentistrybisphosphonatesAgedProportional Hazards ModelsRetrospective StudiesBisphosphonate-associated osteonecrosis of the jawbusiness.industryProportional hazards modelRetrospective cohort study030206 dentistryBisphosphonatemedicine.diseaseosteoporosisSurgeryCross-Sectional StudiesOtorhinolaryngologyMultivariate AnalysisDentistry (all)businessOsteonecrosis of the jaw
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Relationship between Low Bone Mineral Density and Fractures with Incident Cardiovascular Disease: A Systematic Review and Meta-analysis

2017

An increasing evidence base suggests that low bone mineral density (BMD) and fractures are associated with cardiovascular disease (CVD). We conducted a systematic review and meta-analysis summarizing the evidence of low BMD and fractures as risk factors for future CVD. Two independent authors searched major databases from inception to August 1, 2016, for longitudinal studies reporting data on CVD incidence (overall and specific CVD) and BMD status and fractures. The association between low BMD, fractures, and CVD across longitudinal studies was explored by calculating pooled adjusted hazard ratios (HRs) ±95% confidence intervals (CIs) with a random-effects meta-analysis. Twenty-eight studie…

Maleddc:616IncidenceCARDIOVASCULAR DISEASECoronary Artery DiseaseMETA-ANALYSISOSTEOPOROSISArticleDiabetes and MetabolismFractures BoneEndocrinologyBone DensityRisk FactorsBONE MINERAL DENSITY; CARDIOVASCULAR DISEASE; META-ANALYSIS; OSTEOPOROSIS; Endocrinology Diabetes and Metabolism; Orthopedics and Sports MedicineHumansFemaleOrthopedics and Sports MedicineBONE MINERAL DENSITY
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Monoclonal gammopathy of undetermined significance and bone health outcomes: a systematic review and exploratory meta-analysis.

2017

Monoclonal gammopathy of undetermined significance (MGUS) is a common condition in the elderly. A number of studies have investigated the relationship between MGUS and bone health outcomes including bone mineral density (BMD), osteoporosis and fractures, but no meta-analysis exists. We conducted a systematic review and exploratory meta-analysis comparing bone health outcomes in patients with MGUS. Two independent authors searched PubMed and Scopus from inception until 19 October 2016. A meta-analysis of cross-sectional and longitudinal studies investigating fractures and BMD was conducted. Standardised mean differences (SMD) ± 95% confidence intervals (CIs) were calculated for BMD, and risk…

Malemedicine.medical_specialtyAgingEndocrinology Diabetes and MetabolismOsteoporosis030209 endocrinology & metabolismMonoclonal Gammopathy of Undetermined SignificanceBone and Bones03 medical and health sciencesFractures Bone0302 clinical medicineEndocrinologyBone DensityInternal medicinemedicineOdds RatioPrevalenceHumansOrthopedics and Sports MedicineLongitudinal StudiesFemoral neckAgedBone mineralbusiness.industryIncidence (epidemiology)IncidenceGeneral MedicineMiddle Agedmedicine.diseaseConfidence intervalAging; Fractures; Monoclonal gammopathy of undetermined significance; OsteoporosisSurgeryDiabetes and Metabolismmedicine.anatomical_structureCross-Sectional StudiesMonoclonal gammopathy of undetermined signifcance Osteoporosis Fractures Aging030220 oncology & carcinogenesisMeta-analysisRelative riskCase-Control StudiesAging; Fractures; Monoclonal gammopathy of undetermined significance; Osteoporosis; Endocrinology Diabetes and Metabolism; Orthopedics and Sports Medicine; EndocrinologyOsteoporosisFemalebusinessFracturesMonoclonal gammopathy of undetermined significanceJournal of bone and mineral metabolism
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Physiology of the aging bone and mechanisms of action of bisphosphonates.

2011

Fragility fractures, a major public health concern, are expected to further increase due to aging of the world populations because age remains a cardinal, independent determinant of fracture risk. With aging the balance between bone formation and resorption during the remodeling process becomes negative, with increased resorption and reduced formation. Bisphosphonates (BPs) are widely prescribed anti-resorptive agents that inhibit osteoclasts attachment to bone matrix and enhance osteoclast apoptosis. BPs can be divided into nitrogen-containing (N-BPs) and non-nitrogen-containing BPs (non-N-BPs). Both classes induce apoptosis but they evoke it differently. Several studies have examined the …

Malemedicine.medical_specialtyAgingSettore MED/09 - Medicina Internamedicine.medical_treatmentOsteoporosisurologic and male genital diseasesBone resorptionBone and BonesBone remodelingOsteoclastInternal medicinemedicineHumansCellular SenescenceBONE BONE TURNOVER FRAGILITY FRACTURES AGING BISPHOSPHONATESOsteoblastsBone Density Conservation AgentsDiphosphonatesbusiness.industryBone metastasisOsteoblastBisphosphonatemedicine.diseaseEndocrinologymedicine.anatomical_structureOsteocyteFemaleBone RemodelingGeriatrics and GerontologybusinessGerontologyhormones hormone substitutes and hormone antagonistsBiogerontology
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