Search results for "OSTEOPOROSI"

Osteoporosi, osteoartrosi ed attività motorie

2008

studio osservazionale retrospettivo della correlazione tra riduzione della massa ossea e disturbi comportamentali

Nel nostro studio sono stati esaminati due gruppi di soggetti, così suddivisi, un gruppo già con diagnosi strumentale di riduzione della massa ossea ed un gruppo controllo. Nel reclutamento del gruppo di controllo sono stati esclusi soggetti di età superiore a 65 anni, in terapia cortisonica per patologie croniche da più di sei mesi, individui che evidenziano all’anamnesi fattori che aumentano il rischio o le conseguenze delle cadute, quali disabilità, fattori ambientali, consumo di benzodiazepine, abuso di alcol o droghe, o con patologie note che possano essere responsabili di osteoporosi secondaria. La scheda di valutazione anamnestica, nei pazienti affetti da osteoporosi o osteopenia è c…

Correlation between osteoporosis and cardiovascular disease

2014

Several evidences have shown in the last years a possible correlation between cardiovascular diseases and osteoporosis. Patients affected with osteoporosis, for example, have a higher risk of cardiovascular diseases than subjects with normal bone mass. However, the heterogeneous approaches and the different populations that have been studied so far have limited the strength of the findings. Studies conducted in animal models show that vascular calcification is a very complex mechanism that involves similar pathways described in the normal bone calcification. Proteins like BMP, osteopontin, osteoprotegerin play an important role at the bone level but are also highly expressed in the calcifie…

El prolapso genital como factor de riesgo de fractura osteoporótica en la mujer

2022

El estudio consiste en analizar la correlación existente entre el prolapso genital y la fractura osteoporótica, ambas patología de alta prevalencia en la mujer envejecida. Ya existen indicios biblliográficos (en estudios de datos poblacionales) de esta posible asociación, pero siempre de manera retrospectiva y nunca buscando esta asociación como objetivo principal, con los sesgos inherentes a cada perfil de estudio. Proponemos un estudio analítico, observacional y prospectivo con el fin de demostrar nuestra hipótesis principal; que el propaso de órganos pélvicos es un factor de riesgo independiente para fractura osteoporótica. Como objetivo secundario, intentaremos demostrar que existen mar…

Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020

2020

The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention (primary and secondary). The present paper reports the update of the conclusions from the Consensus Conference—held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)—after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SI…

Bone Density, Balance and Quality of Life of Postmenopausal Women Taking Alendronate Participating in Different Physical Activity Programs

2010

Made available in DSpace on 2022-04-28T19:04:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01 Background: The objective of this study was to determine the effects of different physical activity (PA) programs on bone density, balance and quality of life of postmenopausal women taking concomitant alendronate. A quasi-experimental study was conducted with 35 volunteers divided into four groups: practitioners of resistance training (RTG, n = 9, 49.8±4.2 years), judo (JUG, n = 11, 52.2±5.3 years), water aerobics (WAG, n = 8, 57.1±7.4 years) and the control group (CG, n = 7, 53.8±4.4 years). Methods: The following assessment tools were used: bone mineral density (BMD) measured by d…

Anti-resorptive treatment in osteoporosis and their deleterious effects on maxillary bone metabolism in clinical dentistry

2017

Bisphosphonates (BPs) and other antiresorptive agents such as denosumab are widely prescribed for the treatment of osteoporosis and are also used in patients with multiple myeloma and metastatic breast or prostate cancer for avoiding bone reabsorption and fractures that result in increased morbidity–mortality among such individuals. Osteonecrosis of the jaws is an important complication of exposure to BPs or other antiresorptive agents, and although its prevalence is low, it can pose management problems. The definition, diagnosis, and classification of osteonecrosis have evolved since Marx reported the first cases in 2003. The present chapter offers a review and update on the existing diagn…

Tomographic study of Jaw bone changes in patients with bisphosphonate-related osteonecrosis

2020

Background Bisphosphonates (BP) are synthetic pyrophosphate-like substances with antiresorptive properties and specifically affect osteoclastic activity. In 2007, the American Association of Oral and Maxillofacial Surgeons (AAOMS) defined diagnostic criteria for Osteonecrosis of the Jaws Associated with Bisphosponates (BRONJ). BRONJ is mainly diagnosed by clinical features, but the detection of early bone changes by imaging may help prevent and better understand the disease. The objective of this study was to evaluate maxillary changes in CBCT in patients using BP. Material and methods All included patients were diagnosed with osteonecrosis and received bisphosphonate drugs in the last ten …

Peptide-Capped Mesoporous Nanoparticles: Toward a more Efficient Internalization of Alendronate

2020

[EN] Osteoporosis is an illness which appears when the osteoblast/osteoclast activities are unbalanced taking place bone resorption (caused by osteoclasts) in higher extension than bone formation (induced by osteoblasts). Alendronate is one of the most used drugs for osteoporosis treatment despite its scarce bioavailability. Here we present the synthesis and characterization of mesoporous gated nanoparticles (two sets) for the controlled release of alendronate. The first set of nanoparticles (S1) were loaded with sulforhodamine B and capped with a peptide that could be selectively hydrolyzed by cathepsin K enzyme (overexpressed in osteoclasts). The second set (S2) was functionalized with am…

Collagen overglycosylation: a biochemical feature that may contribute to bone quality.

2005

Skeletal ability to resist mechanical stress is determined by bone amount and quality, which relies on macro- and micro-architecture, turnover, bone matrix, and mineralisation; the role of collagen has not been clearly elucidated. Numerous post-translational steps are involved in collagen type I biosynthesis, including residue hydroxylation and glycosylation catalysed by enzymes that work until the protein folds forming the triple helix; therefore, folding rate regulates these processes. Overglycosylated hydroxylysines are poor substrates for epsilon-amino group deamination which initiates cross-link formation. Three clinical conditions associated with fractures may relate collagen overglyc…