Search results for "OSTEOPOROSIS"
showing 10 items of 393 documents
Are the serum levels of sCD40L modified by raloxifene in postmenopausal women?
2008
Muscle Cross-Sectional Area and Structural Bone Strength Share Genetic and Environmental Effects in Older Women
2009
The purpose of this study was to estimate to what extent muscle cross-sectional area of the lower leg (mCSA) and tibial structural strength are influenced by common and trait-specific genetic and environmental factors. pQCT scans were obtained from both members of 102 monozygotic (MZ) and 113 dizygotic (DZ) 63- to 76-yr-old female twin pairs to estimate the mCSA of the lower leg, structural bending strength of the tibial shaft (BSIbend), and compressive strength of the distal tibia (BSIcomp). Quantitative genetic models were used to decompose the phenotypic variances into common and trait-specific additive genetic (A), shared environmental (C), and individual environmental (E) effects. The …
Hsp60 and human aging: Les liaisons dangereuses
2013
Stressors can cause abnormal intracellular accumulation of Hsp60 and its localization in extramitochondrial sites, secretion, and circulation, with immune system activation. Dysfunction of chaperones associated with their quantitative and qualitative decline with aging (chaperonopathies of aging) characterizes senescence and is a potential causal factor in the physiological deterioration that occurs with it. The role of Hsp60 in aging is not easy to elucidate, because aging is accompanied by pathologies (e.g., cardiovascular and neurodegenerative disorders, osteoporosis, diabetes, cancer, etc.) in which Hsp60 has been implicated but, although those disorders are more frequent in the elderly…
Osteoporosis, jawbones and periodontal disease
2012
The association between osteoporosis and jawbones remains an argument of debate. Both osteoporosis and periodontal diseases are bone resorptive diseases; it has been hypothesized that osteoporosis could be a risk factor for the progression of periodontal disease and vice versa. Hypothetical models linking the two conditions exist: in particular, it is supposed that the osteoporosis-related bone mass density reduction may accelerate alveolar bone resorption caused by periodontitis, resulting in a facilitated periodontal bacteria invasion. Invading bacteria, in turn, may alter the normal homeostasis of bone tissue, increasing osteoclastic activity and reducing local and systemic bone density …
BPCO E OSTEOPOROSI
2013
COPD and osteoporosis are frequently associated because they have common risk factors, including age, smoking habits and reduced physical activity. COPD is also characterized by systemic inflammation, malnutrition (up to cachexia), hypovitaminosis D, and the use of local and systemic corticosteroids, all of which could cause deterioration in bone quality with a consequent increase in fragility fractures. These fractures may further impair mobility and increase disability and mortality. The vertebral and rib fractures can directly further affect lung function and promote exacerbations. As a result, the assessment of fracture risk in patients with COPD is of vital importance from the earliest…
FRAGILITY FRACTURES IN OLDER PERSONS WITH ALTERED THYROID FUNCTION
2016
Gli ormoni tiroidei sono peptidi che svolgono molteplici e complesse funzioni nell’organismo umano. Lo sche-letro è uno dei tessuti bersaglio degli ormoni tiroidei, ed una loro carenza o un loro eccesso ha importanti conseguenze sul tessuto osseo soprattutto nel periodo dello sviluppo e durante l’invecchiamento. I disturbi a carico della tiroide si osservano con maggior frequenza nei soggetti in età avanzata rispetto ai giovani. La tire-otossicosi è una causa nota di osteoporosi secondaria. L’ipertiroidismo conclamato e l’ipertiroidismo iatrogeno dovuto ad un eccesso nel dosaggio della terapia sostitutiva con ormoni tiroidei sono possibili cause di fratture ossee da fragilità. L’ipertiroidi…
Osteoporosis in pregnancy: A case report and review of the literature
2014
IL PAZIENTE ANZIANO CON FRATTURA DI FEMORE: VALUTAZIONE E SUPPORTO NUTRIZIONALE
2013
Osteoporosis in the elderly population is a major health problem worldwide, because it is associated with fragility fractures with consequent financial burden for health systems. Europe and North America are the regions where half of all hip fractures among elderly people occurred today, with Scandinavian countries reporting the highest incidence worldwide. Undernutrition, particularly protein malnutrition, is frequent in elderly with osteoporotic hip fracture, although, the role of dietary protein intake in osteoporosis remains controversial. Poor nutritional status is associated with higher comorbidity indices, mortality and readmissions in patients with femoral fracture. Another crucial …
Role of genetic predisposition as a risk factor for osteoporosis.
2005
BONE LOSS I INFLAMMATORI BOWEL DISEASE: OUR MULTICENTRIC STUDY
2011
Patients with inflammatory bowel disease are at increased risk of developing disorder in bone and mineral metabolism. The study was aimed to determine if inflammatory bowel disease (IBD) is a risk factor for osteoporosis in 103 adult patients. We included 103 IBD patients, 67 patients with Crohn's disease (CD) and 36 with ulcerative colitisi (UC). Bone mineral density was measured by dual-energy X-ray absorptiometry. we used T score to express bone loss (osteopenia: -25SD 2 years) and active disease would be risk of bone mineral loss in IBD.