Search results for "OSTEOPOROSIS"
showing 10 items of 393 documents
Effect of chondroitin sulphate and glucosamine in combination in an animal model of osteoarthritis and osteoporosis
2014
Efectos de la Hormona Paratiroidea PTH (1-84) en la consolidación de las fracturas
2015
1.- INTRODUCCIÓN La osteoporosis es una enfermedad sistémica crónica y progresiva que se caracteriza por una densidad ósea baja y un deterioro de la micro-arquitectura del tejido óseo, que reduce la resistencia a las fuerzas de carga, con un incremento de la fragilidad ósea y de la susceptibilidad de experimentar una fractura ante mínimos traumatismos. Por lo tanto, las fracturas por fragilidad son la consecuencia clínica de la osteoporosis. La incidencia de este tipo de fracturas es muy alta y con el envejecimiento de la población continúa aumentando. Las fracturas de cadera son las más importantes por sus consecuencias en cuanto a mortalidad (20-30% en el primer año) y morbilidad (sólo el…
Biosilica-Based Strategies for Treatment of Osteoporosis and Other Bone Diseases
2011
Osteoporosis is a common disease in later life, which has become a growing public health problem. This degenerative bone disease primarily affects postmenopausal women, but also men may suffer from reduced bone mineral density. The development of prophylactic treatments and medications of osteoporosis has become an urgent issue due to the increasing proportion of the elderly in the population. Apart from medical/hormonal treatments, current strategies for prophylaxis of osteoporosis are primarily based on calcium supplementation as a main constituent of bone hydroxyapatite mineral. Despite previous reports suggesting an essential role in skeletal growth and development, the significance of …
V?9V?2 T lymphocytes activation in osteoporotic patients treated with bisphosphonates
2014
Treatment with bisphosphonates induces differentiation and activation of Vγ9Vδ2 T lymphocytes obtained from peripheral blood showing also an antitumoral effect in both in vitro and in vivo models. Aim of the present study was to determine in vivo the effect of BPs treatment in patients affected with osteoporosis on Vγ9Vδ2 T lymphocytes. We have studied Vγ9Vδ2 T lymphocytes expansion and differentiation from PBMC obtained from osteoporotic patients treated with one of the following bisphosphonates zoledronate, alendronate, neridronate or risedronate. We have found that zoledronic acid, followed by alendronate was the most effective on reducing CM population (100%) and increasing TEM and TEMR…
Adverse reactions to the injection of face and neck aesthetic filling materials: a systematic review
2022
Adverse reactions, caused during the inflammation and healing process, or even later, can be induced by the injection of dermal filler and can present a variety of clinical and histological characteristics. In this study we aimed to review the adverse reactions associated with the injection of aesthetic filling materials in the face and neck. The review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Studies published that mentioned adverse reactions in patients with aesthetic filling materials in the face or neck were included. Risk of bias was assessed using the Joanna Briggs Institute appraisal tool. After a 2-step selection pro…
Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease
2020
Purpose: To evaluate circulating irisin levels in patients with active and controlled Cushing’s disease (CD). Design: Forty-four patients with CD evaluated during the active phase and after 12 months of biochemical remission and 40 controls were recruited. Methods: Phenotypic, anthropometric, hormonal and metabolic parameters, including insulin sensitivity estimation by homeostatic model of insulin resistance, Matsuda index and oral disposition index and circulating irisin levels were evaluated. Results: Patients with active CD showed lower irisin levels compared to controls (p<0.001) and controlled CD (p<0.001). The independent variables significantly associated with irisin were wais…
Pathophysiology of age-related diseases
2009
Abstract A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy on 7-8 April 2009. Three lectures from that Symposium by G. Campisi, L. Ginaldi and F. Licastro are here summarized. Ageing is a complex process which negatively impacts on the development of various bodily systems and its ability to function. A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Thus, a better understanding of the pathophysiology of age-related diseases is urgently required to improve our understanding of maintaining good health in the elderly and to program possible therapeutic intervention.
Physical activity, nutrition, and bone health
2018
This review aims to describe the roles that physical activity and nutrition have in bone metabolism and to examine their effects on bone in a situation of altered metabolism as a consequence of inadequate nutrition and/or excessive physical activity. Referring to the recent studies and the main guidelines in the literature on athlete nutrition, the paper also focuses on essential nutrients for bone health during performance. Finally, it discusses the negative effect of some nutrients on bone mineral density.
Targeted exercise against osteoporosis: A systematic review and meta-analysis for optimising bone strength throughout life
2010
Background. Exercise is widely recommended to reduce osteoporosis, falls and related fragility fractures, but its effect on whole bone strength has remained inconclusive. The primary purpose of this systematic review and meta-analysis was to evaluate the effects of long-term supervised exercise (≥6 months) on estimates of lower-extremity bone strength from childhood to older age. Methods. We searched four databases (PubMed, Sport Discus, Physical Education Index, and Embase) up to October 2009 and included 10 randomised controlled trials (RCTs) that assessed the effects of exercise training on whole bone strength. We analysed the results by age groups (childhood, adolescence, and young and …