Search results for "OSiS"
showing 10 items of 15931 documents
The use of diagnostic tools in GAMLSS for liver fibrosis detection
Ecologists overestimate the importance of predictor variables in model averaging: a plea for cautious interpretations.
2014
Abstract: Information-theory procedures are powerful tools for multimodel inference and are now standard methods in ecology. When performing model averaging on a given set of models, the importance of a predictor variable is commonly estimated by summing the weights of models where the variable appears, the so-called sum of weights (SW). However, SWs have received little methodological attention and are frequently misinterpreted. We assessed the reliability of SW by performing model selection and averaging on simulated data sets including variables strongly and weakly correlated to the response variable and a variable unrelated to the response. Our aim was to investigate how useful SWs are …
The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies.
2021
Since the approval of the first monoclonal antibody (mAb) in 1986, a huge effort has been made to guarantee safety and efficacy of therapeutic mAbs. As of July 2021, 118 mAbs are approved for the European market for a broad range of clinical indications. In order to ensure clinical efficacy and safety aspects, (pre-)clinical experimental approaches evaluate the respective modes of action (MoA). In addition to antigen-specificity including binding affinity and -avidity, MoA comprise Fc-mediated effector functions such as antibody dependent cellular cytotoxicity (ADCC) and the closely related antibody dependent cellular phagocytosis (ADCP). For this reason, a variety of cell-based assays have…
Caracterización Fenética y Genética de Individuos del Género Fasciola Linnaeus, 1758 (Trematoda: Fasciolidae) de México
2017
La fascioliasis es una importante enfermedad causada por dos especies de trematodos, Fasciola hepatica y Fasciola gigantica, que incluye un amplio espectro de especies hospedadoras definitivas tanto domésticas como silvestres. En el presente trabajo, como primer paso, se realizó una revisión bibliográfica exhaustiva de todos los casos humanos de fascioliasis en México, reportados tanto en la literatura mexicana, como casos de pacientes mexicanos diagnosticados en Canadá y USA. El estudio fenético y genético se realizó con adultos del parásito, obtenidos de bovinos del matadero de la Ciudad de Toluca, Estado de México, México, zona de endemia humana. Para el estudio fenético comparativo se u…
A genomic reappraisal of symbiotic function in the aphid/Buchnera symbiosis: reduced transporter sets and variable membrane organisations.
2011
International audience; Buchnera aphidicola is an obligate symbiotic bacterium that sustains the physiology of aphids by complementing their exclusive phloem sap diet. In this study, we reappraised the transport function of different Buchnera strains, from the aphids Acyrthosiphon pisum, Schizaphis graminum, Baizongia pistaciae and Cinara cedri, using the re-annotation of their transmembrane proteins coupled with an exploration of their metabolic networks. Although metabolic analyses revealed high interdependencies between the host and the bacteria, we demonstrate here that transport in Buchnera is assured by low transporter diversity, when compared to free-living bacteria, being mostly bas…
Application of tRNS to improve Multiple Sclerosis Fatigue: a sham-controlled study
2018
Background and aims: Fatigue is one of the most common, early, and disabling symptom in Multiple Sclerosis (MS). tDCS on Dorso-Lateral Prefrontal Cortex seems to give positive results on MS fatigue. Recently, a new stimulation protocol, transcranial Random Noise Stimulation (tRNS), showed powerful facilitatory effects on motor cortex in healthy subjects and ameliorated pain in MS patients. Here we aimed to explore effects of motor cortex tRNS in MS fatigue.Methods: 13 MS fatigued patients were enrolled in a blind, sham controlled tRNS study. 7 patients received 1.5 mA, 101-640 Hz tRNS stimulation and 6 patient received sham stimulation, both stimulations applied daily over M1 for 15 minutes…
Positive or negative involvement of heat-shock proteins in multiple sclerosis pathogenesis: an overview.
2014
Clinical Features and disease outcome in pt with pediatric and young adult onset multiple sclerosis
2012
The risk of disease worsening according to the length of exposure to IFNb in multiple sclerosis
2005
Correction to: Disability assessment using Google Maps (Neurological Sciences, (2022), 43, 2, (1007-1014), 10.1007/s10072-021-05389-7)
2022
Originally, the article has been published online with a spelling error in author name. The correct author name is Paolo Ragonese and not Paolo Raganose. The original article has been corrected.