Search results for "OSiS"
showing 10 items of 15931 documents
TRAIL acts synergistically with iron oxide nanocluster-mediated magneto- and photothermia
2019
International audience; Targeting TRAIL (Tumor necrosis factor (TNF)-Related Apoptosis-Inducing Ligand) receptors for cancer therapy remains challenging due to tumor cell resistance and poor preparations of TRAIL or its derivatives. Herein, to optimize its therapeutic use, TRAIL was grafted onto iron oxide nanoclusters (NCs) with the aim of increasing its pro-apoptotic potential through nanoparticle-mediated magnetic hyperthermia (MHT) or photothermia (PT). Methods: The nanovector, NC@TRAIL, was characterized in terms of size, grafting efficiency, and potential for MHT and PT. The therapeutic function was assessed on a TRAIL-resistant breast cancer cell line, MDA-MB-231, wild type (WT) or T…
La città e la dimensione ambientale: il paradigma dei servizi ecosistemici nella pianificazione alla scala urbana
Course and Predictors of Pain and Physical Functioning in Patients with Hip Osteoarthritis: Systematic Review and Meta-Analysis
2016
Objective: To systematically summarize the literature on: (i) the course of pain and physical functioning; and (ii) predictors of deterioration of pain and physical functioning in patients with osteoarthritis of the hip. Methods: A literature search was conducted in PubMed, CINAHL, Embase, PsychINFO and SPORTDiscus up to July 2015. Meta-analyses and qualitative data syntheses were performed. Results: Eleven of the 15 included studies were of high quality. With regard to the course of pain and physical functioning, high heterogeneity was found across studies (I2 >71%) and within study populations (reflected by large standard deviations of change scores). Therefore, the course of pain and phy…
La anamorfosis como acontecimiento visual
2015
A pesar de que el de anamorfosis es un concepto cuya definición parece clara, se observa vacilación e incluso contradicción a la hora de calificar como tal a diversos tipos de imágenes. Este trabajo busca establecer de la manera más precisa posible qué es y qué no es anamorfosis. Para ello revisa las notas o componentes esenciales que se hallan en las definiciones que se han hecho desde su aparición como neologismo en 1657. Profundiza en las fuentes de confusión que se derivan de ideas como "deformación", "transformación" y "engaño", para establecer las diferencias entre anamorfosis y otros tipos de imágenes con las que suele ser confundida, especialmente con el trampantojo, las correccione…
Plasma PAF-acetylhydrolase in patients with coronary artery disease: results of a cross-sectional analysis.
2003
Inflammation underlies both onset and perpetuation of atherosclerosis. Plasma lipoproteins transport the platelet-activating factor-acetylhydrolase (PAF-AH) with potentially anti-inflammatory activities. Our aim was to determine whether PAF-AH activity was associated with inflammatory markers and with coronary artery disease (CAD). PAF-AH activity and a panel of inflammatory mediators were measured in plasma of 496 patients with CAD and in 477 controls; 276 patients presented with stable angina pectoris and 220 with acute coronary syndrome (ACS). Individuals within the highest quartile of PAF-AH activity had an 1.8-fold increase in CAD risk [95% confidence interval (CI), 1.01 to 3.2; P = 0.…
Identificación de genes y polimorfismos asociados a fenotipos óseos
2017
El deterioro óseo sucede principalmente como consecuencia del envejecimiento en ambos sexos y particularmente con la depleción estrogénica que ocurre durante la menopausia en la mujer. Este deterioro en la calidad ósea puede desembocar finalmente en el desarrollo de patologías óseas como la osteoporosis, y en última instancia en el fenotipo clínico de peor pronóstico, la fractura ósea por fragilidad. Ambos fenotipos, la osteoporosis y la fractura por fragilidad, se consideran patologías complejas o multifactoriales; esto es, influenciadas por múltiples factores entre los que se encuentran factores genéticos, epigenéticos o ambientales. En la caracterización de los factores genéticos que int…
Improvements in Rational Design Strategies of Inulin Derivative Polycation for siRNA Delivery.
2016
The advances of short interfering RNA (siRNA)-mediated therapy provide a powerful option for the treatment of many diseases, including cancer, by silencing the expression of targeted genes involved in the progression of the pathology. On this regard, a new pH-responsive polycation derived from inulin, Inulin-g-imidazole-g-diethylenetriamine (INU-IMI-DETA), was designed and employed to produce INU-IMI-DETA/siRNA "Inulin COmplex Nanoaggregates" (ICONs). The experimental results showed that INU-IMI-DETA exhibited strong cationic characteristics and high solubility in the pH range 3-5 and self-aggregation triggered by pH increase and physiological salt concentration. INU-IMI-DETA showed as well…
PMN membrane fluidity, cytosolic Ca2+ content and beta2-integrin pattern in vascular atherosclerotic disease
2010
Regulatory networks underlying mycorrhizal development delineated by genome-wide expression profiling and functional analysis of the transcription fa…
2017
Background: Ectomycorrhizal (ECM) fungi develop a mutualistic symbiotic interaction with the roots of their host plants. During this process, they undergo a series of developmental transitions from the running hyphae in the rhizosphere to the coenocytic hyphae forming finger-like structures within the root apoplastic space. These transitions, which involve profound, symbiosis-associated metabolic changes, also entail a substantial transcriptome reprogramming with coordinated waves of differentially expressed genes. To date, little is known about the key transcriptional regulators driving these changes, and the aim of the present study was to delineate and functionally characterize the trans…
W kierunku konserwacji zdrowia - profilaktyka pozytywna
2018
Profilaktyka pozytywna stanowi nową koncepcję profilaktyki zachowań ryzykownych dzieci i młodzieży. Jest systemem działania zorientowanym na ideał wychowawczy oparty na czynnikach chroniących. W związku z przeformułowaniem akcentu działań powstała potrzeba zarówno weryfikacji założeń poziomów diagnozy, jak i roli specjalisty zewnętrznego.