Search results for "OSiS"

INFLUENZA DELL’ATEROSCLEROSI CAROTIDEA PRECLINICA SUGLI EVENTI CEREBRO- E CARDIOVASCOLARI IN 5 ANNI DI FOLLOW-UP. INFLUENCE OF PRECLINICAL CAROTID AT…

2009

Introduzione: numerosi studi hanno utilizzato la valutazione dello spessore intima-media carotideo (IMT) come marker di aterosclerosi (ATS) preclinica ed è stato ampiamente dimostrato che l’IMT correla con la presenza di ATS coronarica ed è predittivo di eventi sia cardio- che cerebrovascolari. Scopo dello studio: valutare se in soggetti asintomatici la presenza di ATS carotidea preclinica, ispessimento medio intimale carotideo (IMT) e placca carotidea asintomatica (PCA), aggiunga ulteriori informazioni nella stratificazione del rischio permettendo di individuare soggetti che potrebbero beneficiare di un trattamento più aggressivo, anche farmacologico, dei fattori di rischio presenti. Mater…

Molecular investigation on the etiology of preeclampsia and new strategies for its early diagnosis

2023

Endometrial decidualization is critical for pregnancy establishment and maintenance. This process promotes endometrial remodeling allowing placental cytotrophoblasts (CTBs) invasion up to an appropriate depth to form the maternal-fetal interface. A shallow CTBs invasion compromises healthy pregnancy and it is associated with the development of severe preeclampsia (sPE). Our working hypothesis is that defective decidualization impairs the adaptation of the maternal “soil” ─the decidua─ to be invaded by CTBs and plays a pivotal role in the etiology of sPE. Previously, we have demonstrated the existence of an in vitro defective decidualization of endometrial stromal cells isolated from women w…

Evaluation and improvement of the quality of the discharge prescription in Cystic Fibrosis children hospitalised for intravenous antibiotic therapy

2017

1.Antecedentes. La Fibrosis Quística (FQ) es una enfermedad conocida desde la edad media, aunque durante esa época no estaba descrita como tal sino más bien como un hechizo maligno. En 1943, Farber propuso el término mucoviscidosis y este término se sigue utilizando en la actualidad. La FQ es la enfermedad hereditaria autosómica recesiva grave más frecuente en la población blanca, con una incidencia en Europa que oscila entre 1:1.353 en Irlanda y entre 1:25.000 en Finlandia, y una frecuencia de portadores de 1 por cada 2527. Es una enfermedad de las células epiteliales exocrinas, que se caracteriza por la producción de un moco espeso y viscoso que obstruye los conductos del órgano donde se …

Adrb3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis1

2008

The pathophysiology underlying preterm labor triggered by inflammatory conditions such as chorioamnionitis remains largely unclear. It has already been suggested that beta-3 adrenergic (ADRB3) agonists might be of interest in the pharmacological management of preterm labor. Although there is evidence implicating ADRB receptors in the control of inflammation, there are minimal data relating specifically to ADRB3. To explore the cellular consequences of chorioamnionitis and detect apoptosis, we first performed immunostaining and Western blot experiments on human myometrial samples obtained from women with confirmed chorioamnionitis. We then developed an in vitro model of chorioamnionitis by i…

Mycobacterium tuberculosis rezistences noteikšana pret pirmās rindas prettuberkulozes medikamentiem

2019

Neskatoties uz mūsdienu medicīnas attīstību, tuberkuloze joprojām ir viens no lielākiem draudiem cilvēcei. Tuberkulozi izraisa Mycobacterium tuberculosis un šai baktērijai ir raksturīga izteikta rezistence pret antibakteriāliem līdzekļiem. Darbā tiek apkopota literatūra par M. tuberculosis, prettuberkulozes medikamentiem, rezistences mehānismiem un statistikas dati par tuberkulozes saslimšanu Latvijā un pasaulē. Praktiskā daļā tika iegūti dati par zāļu jutības testu rezultātiem (ar BACTEC MGIT) periodā no 2018. gada 2. janvāra līdz 2019. gada 23. janvārim Tuberkulozes un plaušu slimību centrā. Kopumā, saslimšana ar tuberkulozi samazinās gan Latvijā, gan pasaulē, kā arī, pateicoties pareizām…

Efecto de la dosis de intervención del Programa de Apoyo Psicológico P/Materno Infantil© sobre las madres y sus bebés

2014

This paper presents an analysis of the intervention dose-effect of the Parent Child Psychological Support Program© (Cerezo 1990) a program aimed at promoting protective adaptive system in children which is offered to all new-borns in a given catchment area. The program offers support to parents during the first 18 months of the baby's life. The program dose-effect is examined regarding the parents by examining the level of distress reported by them and with babies by examining the development of attachment using the Strange Situation test of Ainsworth et al. (1978). The study is based on 342 families who made between 2 and 4 visits to the Program before being evaluation post-intervention. T…

The importance of prevention in the diagnosis and treatment of oral cancer

2018

Periodontitis and alzheimer´s disease

2020

Background Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays a fundamental role in its onset and progression. The bacteria present in the disbiotic microbiome generated during the course of periodontitis (PE) are capable of inducing a systemic inflammatory response, exacerbating the production of proinflammatory mediators that have the potential to spread to the systemic circulation. Material and Methods A literature review was made using the databases Scielo, PubMed, EBSCO and key words "Alzheimer disease", "Periodontitis", "Neurodegeneration", "Inflammati…

Ceļa locītavu artrozes profilaktiskie pasākumi

2017

Bakalaura darba tēmas – “Ceļa locītavu artrozes profilaktiskie pasākumi” ietvaros analizēti 36 literatūras avoti, no tiem 11 latviešu valodā, 7 krievu valodā, 16 angļu valodā un 1 vācu valodā. Ar ceļa locītavu artrozes saslimšanu pasaulē slimo 630 miljonus cilvēku. Katru gadu pacientu skaits pakāpeniski pieaug. Bakalaura darba mērķis ir noskaidrot ceļa locītavu artrozes profilakses pasākumus. Darba gaitā tika analizēti dati, lai sniegtu atbildi uz pētījuma jautājumu - “Kādi ir ceļa locītavu artrozes profilaktiskie pasākumi?” Pētījumā tika izmantota kvalitatīvā metode, veikta respondent intervija, kā arī izvērtēts ekspertu viedoklis. Pētījuma veikšanas gaitā tika noskaidroti būtiskākie ceļa …

Efecto terapéutico del compuesto BO-110 en un modelo animal de leiomioma

2023

Los miomas son los tumores benignos más frecuentes en las mujeres en edad reproductiva y pueden asociar numerosos síntomas como dolor, sangrado y problemas reproductivos. Sin embargo, actualmente no existe una terapia totalmente satisfactoria por lo que es de suma importancia la evaluación de nuevos tratamientos. En la búsqueda de opciones terapéuticas alternativas, hemos seleccionado el ácido poliinosina-policitidílico (pIC) conjugado con polietilenimina (PEI) [pICPEI], cuyo nombre comercial es BO-100. El compuesto pIC es un ARN sintético de doble cadena sin toxicidad asociada, que induce de manera selectiva la autofagia y apoptosis en un gran espectro de células tumorales. Presen…