Search results for "OSiS"

TP53 mutations and S-phase fraction but not DNA-ploidy are independent prognostic indicators in laryngeal squamous cell carcinoma

2005

To prospectively evaluate the prognostic significance of TP53, H-, K-, and N-Ras mutations, DNA-ploidy and S-phase fraction (SPF) in patients affected by locally advanced laryngeal squamous cell carcinoma (LSCC). Eight-one patients (median follow-up was 71 months) who underwent resective surgery for primary operable locally advanced LSCC were analyzed. Tumor DNA was screened for mutational analysis by PCR/SSCP and sequencing. DNA-ploidy and SPF were performed by flow cytometric analyses. Thirty-six patients (44%) had, at least, a mutation in the TP53 gene. Of them, 22% (8/36) had double mutations and 3% (1/36) had triple mutations. In total, 46 TP53 mutations were observed. The majority (41…

La valeur partenariale : vers une mesure opérationnelle.

2007

L’objectif de cet article est de proposer une mesure operationnelle de la valeur partenariale. Cette mesure est illustree par une application a un certain nombre de firmes europeennes du secteur automobile. Cette application met en evidence l’interet de la demarche pour construire un diagnostic financier permettant de mieux mettre en relation la conception contractuelle de la firme et l’approche strategique.

Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases.

2022

Vitamin D is a steroid hormone regulating calcium-phosphorus homeostasis, immune response and brain function. In the past thirty years, an increasing number of cohort studies, meta-analyses and randomized controlled trials (RTCs) evaluated the serum levels of 25-hydroxyvitamin D [25(OH)D], which is considered the Vitamin D status biomarker, in patients affected by neurological, psychiatric and autoimmune diseases. Although an association between low 25(OH)D serum levels and the prevalence of these diseases has been found, it is still unclear whether the serum 25(OH)D measurement can be clinically useful as a biomarker for diagnosis, prognosis and predicting treatment response in neurodegene…

Implicación y caracterización de Staphylococcus aureus en las poliposis nasales.

2016

La rinosinusitis crónica (RSC) es una enfermedad inflamatoria, de más de 12 semanas de duración, que afecta a la mucosa de las fosas nasales y de los senos paranasales. Se caracteriza por presentar, obstrucción o congestión nasal, y/o rinorrea; y además poder presentar uno de estos dos síntomas, dolor o sensación de presión facial, y/o pérdida total o parcial del sentido del olfato. La RSC se divide en dos grupos RSC con ausencia o RSC con presencia de poliposis nasal (PN). Además clínicamente la rinosinusitis crónica con presencia de poliposis nasal (RSCcPN) pueden subclasificarse en (a) RSCcPN eosinofílica, que es bilateral e idiopática, pudiendo presentarse de forma aislada, asociada a a…

Analisi dei gruppi morfo-funzionali del fitoplancton per la determinazione dello stato ecologico degli ecosistemi acquatici continentali.

2011

USE OF THE DRUG ELUTING STENTS WITH RAPAMICIN IN PATIENTS WITH ANATOMICAL OR CLINICAL PATTERNS FAVOURING RESTENOSIS: RESULTS OF A 6-MONTHS FOLLOW-UP …

2004

Graves’ disease

2017

Oral biopsy in dental practice

2007

The conclusions drawn from the study of an oral biopsy are considered essential for the definitive diagnosis of diseases of the oral mucosa, and for the subsequent planning of appropriate treatment. Although the obtainment of biopsies is widely used in all medical fields, the practice is not so widespread in dental practice - fundamentally because of a lack of awareness of the procedure among dental professionals. In this context, it must be taken into account that the early diagnosis of invasive oral malignancy may be critical for improving the patient prognosis. However, in some cases the results are adversely affected by incorrect manipulation of the biopsy material. The present study pr…

The matrix metalloproteinase and insulin-like growth factor system in oral cancer : a prospective clinical study

2017

Aim The absence of reliable single serum biomarkers for oral premalignant lesion (OPL) and oral squamous cell carcinoma (OSCC) limits early diagnosis, monitoring of advanced disease, and prediction of prognosis. Methods In this prospective study, serum levels of matrix metalloproteinase (MMP)-2, MMP-3, MMP-13, insulin-like growth factor (IGF)-1, and IGF-binding protein (IGFBP)-3 were measured in 81 untreated OSCC patients, 49 healthy subjects, and 75 individuals with OPLs, and correlated with clinicopathological parameters. Results Serum levels of MMP-3 were significantly higher in OSCC patients compared to healthy subjects (p=0.004). Mean IGF-1 and IGFBP-3 levels in OSCC patients were sign…

Tumoren der Ceruminaldrüsen

1987

Tumours originating from the ceruminous glands can be classified into five types: adenomas, adenocarcinomas, adenoid-cystic carcinomas, pleomorphic adenomas and mucoepidermoid carcinomas. The diagnosis is based on histological findings and can be quite difficult if the tumour status has to be determined. Classification into one of the five types of tumours may be facilitated at times by studying the clinical pattern. Three case reports are quoted as examples to illustrate that neoplasias originating from the ceruminous glands can assume considerable proportions and must be considered in differential diagnosis when assessing space-occupying growths in the soft tissue of the neck. Whereas pro…