Search results for "OSiS"

Role of osteoprotegerin in the pathogenesis of thalassemia induced osteoporosis

2006

A Particular Focus on the Prevalence of α- and β-Thalassemia in Western Sicilian Population from Trapani Province in the COVID-19 Era

2023

Thalassemia is a Mendelian inherited blood disease caused by α- and β-globin gene mutations, known as one of the major health problems of Mediterranean populations. Here, we examined the distribution of α- and β-globin gene defects in the Trapani province population. A total of 2,401 individuals from Trapani province were enrolled from January 2007 to December 2021, and routine methodologies were used for detecting the α- and β-globin genic variants. Appropriate analysis was also performed. Eight mutations in the α globin gene showed the highest frequency in the sample studied; three of these genetic variants represented the 94% of the total α-th…

Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[ b ]thiophene derivatives

2014

A new series of 3-benzoylamino-5-imidazol-5-yl-benzo[b]thiophenes and the parent amino derivatives were synthesized and screened as antitumor agents. All tested compounds showed concentration-dependent antiproliferative activity profile against HeLa cell line, exhibiting GI50 values in the low micromolar range. The most active compounds were tested in cell cycle perturbation experiments. A rapid accumulation of cells in the G2/M phase, with a concomitant reduction of cells in both the S and G0/G1 phases, was observed, suggesting that cell exposure to selected derivatives produces mitotic failure. To rationalize the biological results, the 3-benzoylamino-benzo[b]thiophenes were analyzed thro…

Prevention of venous thromboembolism in patients with cancer: guidelines of the Italian Society for Haemostasis and Thrombosis

2012

Modified Glasgow Prognostic Score is Associated With Risk of Recurrence in Bladder Cancer Patients After Radical Cystectomy

2015

Recently, many studies explored the role of inflammation parameters in the prognosis of urinary cancers, but the results were not consistent. The modified Glasgow Prognostic Score (mGPS), a systemic inflammation marker, is a prognostic marker in various types of cancers. The aim of the present study was to investigate the usefulness of the preoperative mGPS as predictor of recurrence-free (RFS), overall (OS), and cancer-specific (CSS) survivals in a large cohort of urothelial bladder cancer (UBC) patients.A total of 1037 patients with UBC were included in this study with a median follow-up of 22 months (range 3-60 months). An mGPS = 0 was observed in 646 patients (62.3%), mGPS = 1 in 297 pa…

Toll Like Receptors as Sensors of the Tumor Microbial Dysbiosis: Implications in Cancer Progression

2021

Microbiota is a complex ecosystem of active microorganisms resident in the body of mammals. Although the majority of these microorganisms resides at the distal gastrointestinal tract, high-throughput DNA sequencing technology have made possible to understand that several other tissues of the human body host their own microbiota, even those once considered sterile, such as lung tissue. These bacterial communities have important functions in maintaining a healthy body state and the host immune system has evolved multiple mechanisms by which maintaining a symbiotic relationship with the microbiota. The maintenance of this dialogue allows the induction of protective responses to pathogens and r…

Aplicación clínica de la topografía de superficie de la espalda mediante luz estructurada en el screening, diagnóstico y seguimiento de las deformida…

2014

En condiciones normales la columna vertebral no presenta ninguna curvatura en el plano frontal y cuatro curvaturas fisiológicas en el plano de perfil. Existen patologías en las que se produce una alteración de estas curvaturas fisiológicas, como la escoliosis, la hipercifosis torácica y la cifoescoliosis. La escoliosis consiste en una compleja deformidad tridimensional de la columna vertebral en los tres planos del espacio, consistente en una extensión intervertebral en el plano sagital, una inclinación lateral en el plano frontal y un componente de rotación en el plano axial. La hipercifosis torácica consiste en un aumento por encima de un límite normal de la cifosis torácica fisiológica (…

The Effects of Transcutaneous Spinal Direct Current Stimulation on Neuropathic Pain in Multiple Sclerosis: Clinical and Neurophysiological Assessment

2019

Background: Central neuropathic pain represents one of the most common symptoms in multiple sclerosis (MS) and it seriously affects quality of life. Spinal mechanisms may contribute to the pathogenesis of neuropathic pain in MS. Converging evidence from animal models and neurophysiological and clinical studies in humans suggests a potential effect of transcranial direct current stimulation (tc-DCS) on neuropathic pain. Spinal application of DCS, i.e., transcutaneous spinal DCS (ts-DCS), may modulate nociception through inhibition of spinal reflexes. Therefore, ts-DCS could represents an effective, safe and well-tolerated treatment for neuropathic pain in MS, a largely unexplored topic. This…

Relationship of transforming growth factor-beta1 with tumor necrosis factor-alpha and endothelial activation in patients with stable renal transplant…

2008

Elaboración de un plan de intervención para habilidades sociales en personas con esquizofrenia: estudio piloto del programa CONECTA

2015

Los programas de entrenamiento en Habilidades Sociales (HHSS) son una modalidad de intervención que forma parte de los programas de rehabilitación psicosocial dirigido a los enfermos mentales graves en los sistemas de atención a la salud mental. Estos programas cuentan con una larga trayectoria de implantación desde que se inició la reforma psiquiátrica y con una literatura científica que los avala como una técnica eficaz en el tratamiento de las personas con esquizofrenia. Estos programas se encuentran en la cartera de servicios de los planes de intervención de numerosos países. En España están integrados dentro de diversos dispositivos asistenciales, destacando su utilización en los Centr…