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Innovazione sociale e creatività. Nuovi scenari di sviluppo per il territorio sicano
2018
Innovazione sociale e creatività. Nuovi scenari di sviluppo per il territorio sicano, attraverso il paradigma emergente della Circular Land e alcune esperienze d'innovazione locale in Sicilia, traccia un nuovo scenario di sviluppo in Sicilia, evidenziando le relazioni tra l'innovazione sociale, quale processo territorialmente radicato e il contesto spaziale in cui agisce, e identificando nella dimensione relazionale della connettività il principale campo d'azione per le politiche territoriali regionali. In the contribution Innovation and creativity. New development scenarios for the Sicani area, starting from the emerging concept of Circular Land and from some experiences of local innovatio…
FMECA Application in Tomotherapy: Comparison between Classic and Fuzzy Methodologies
2022
Accident analysis in radiotherapy highlighted the need to increase quality assurance (QA) programs by the identification of failures/errors with very low probability (rare event) but very severe consequences. In this field, a Failure Mode, Effects and Criticality Analysis (FMECA) technique, used in various industrial processes to rank critical events, has been met with much interest. The literature describes different FMECA methods; however, it is necessary to understand if these tools are incisive and effective in the healthcare sector. In this work, comparisons of FMECA methodologies in the risk assessment of patients undergoing treatments performed with helical tomotherapy are reported. …
Epistemic, interpersonal, and moral stances in the construction of us and them in Christian metal lyrics
2011
Religious groupings and subcultures both tend to have well-articulated interests, aims, and values that unite certain people but also alienate those who do not share their interests. The case is then made for the construction of difference between 'us' and 'them'. This paper examines the construction of such a group boundary in the previously little studied context of the Christian metal (CM) music subculture. The focus of analysis is on the kinds of stances that are taken and attributed to 'us' and 'them' in the English lyrics of Finnish CM groups. The particular types of stance are related to questions of epistemology, interpersonality, and morality. The paper shows that the borderlines b…
Newborn crawling and rooting in response to maternal breast odor
2021
International audience; A growing literature shows that perception and action are already tightly coupled in the newborn. The current study aimed to examine the nature of the coupling between olfactory stimuli from the mother and the newborn's crawling and rooting (exploratory movements of the head). To examine the coupling, the crawling and rooting behavior of 28 2-day-old newborns were studied while they were supported prone on a mobility device shaped like a mini skateboard, the Crawliskate®, their head positioned directly on top of a pad infused with either their mother's breast odor (Maternal) or the odor of water (Control). Video and 3D kinematic analyses of the number and types of li…
Catholicisme, patriotisme et sport en Alsace (1898-1939)
2002
L’Elsässischer Turnerbund, devenue en 1918 l’Avant-garde du Rhin, avait pour principe de faire des sportifs de bons catholiques et de bons patriotes. Cet objectif rejoignait en théorie celui de la Fédération gymnastique et sportive des patronages de France à laquelle elle était affiliée depuis la fin de la Première Guerre mondiale. Très vite cependant elle se distingua par sa volonté farouche de préserver son identité régionale et sa conception fédéraliste de la nation.
Méthodologie de modélisation et de caractérisation des réseaux spatiaux. Application au réseau viaire de Paris
2016
International audience; Les graphes spatialisés soulèvent différentes questions qui intéressent plusieurs disciplines, depuis la biologie (veinures de feuilles, réseaux neuronaux) ou la géomorphologie (réseaux fluviaux) jusqu’aux études urbaines (réseaux de transports), sans oublier celle des réseaux d’énergie (réseaux électriques, de gaz ou de pétrole) et de télécommunication. Nous nous concentrerons ici sur les exemples apportés par les réseaux viaires. C’est à travers ceux-ci que nous définirons dans cet article d’abord un objet d’étude multi-échelle, la voie, puis cinq indicateurs liés qui permettront une lecture enrichie de la spatialité urbaine. Nous expliciterons ainsi les particular…
Study of the Strengths and Weaknesses of Nursing Work Environments in Primary Care in Spain
2021
Background: Nursing work environments are defined as the characteristics of the workplace that promote or hinder the provision of professional care by nurses. Positive work environments lead to better health outcomes. Our study aims to identify the strengths and weaknesses of primary health care settings in Spain. Methods: Cross-sectional study carried out from 2018 to 2019. We used the Practice Environment Scale of the Nursing Work Index and the TOP10 Questionnaire of Assessment of Environments in Primary Health Care for data collection. The associations between sociodemographic and professional variables were analyzed. Results: In total, 702 primary care nurses participated in the study. …
Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor
2020
Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …
Safety and immunogenicity of the PRAME cancer immunotherapeutic in metastatic melanoma: results of a phase I dose escalation study
2016
Purpose The PRAME tumour antigen is expressed in several tumour types but in few normal adult tissues. A dose-escalation phase I/II study (NCT01149343) assessed the safety, immunogenicity and clinical activity of the PRAME immunotherapeutic (recombinant PRAME protein (recPRAME) with the AS15 immunostimulant) in patients with advanced melanoma. Here, we report the phase I dose-escalation study segment. Patients and methods Patients with stage IV PRAME-positive melanoma were enrolled to 3 consecutive cohorts to receive up to 24 intramuscular injections of the PRAME immunotherapeutic. The RecPRAME dose was 20, 100 or 500 µg in cohorts 1, 2 and 3, respectively, with a fixed dose of AS15. Advers…
Double blind randomized clinical trial comparing minimally- invasive envelope flap and conventional envelope flap on impacted lower third molar surge…
2022
The latest trend in surgery is to look for minimally invasive procedures, with fewer complications and a shorter recovery time. This study aims to compare the minimally- invasive envelope flap, with smaller incision and fewer dissection and the conventional envelope flap, with a 20mm incision, on impacted mandibular third molar surgery, focusing on the hypothesis that there were no differences in postoperative outcomes. A double-blind randomized clinical trial was designed to compare both incisions, focused on determining the approach with minor postoperative side-effects and minor impact on quality-of-life. A total of 60 patients were enrolled for the study if their presented impacted mand…