Search results for "OTOF"
showing 10 items of 15 documents
Photoferrotrophy: Remains of an Ancient Photosynthesis in Modern Environments
2017
Photoferrotrophy, the process by which inorganic carbon is fixed into organic matter using light as an energy source and reduced iron [Fe(II)] as an electron donor, has been proposed as one of the oldest photoautotrophic metabolisms on Earth. Under the iron-rich (ferruginous) but sulfide poor conditions dominating the Archean ocean, this type of metabolism could have accounted for most of the primary production in the photic zone. Here we review the current knowledge of biogeochemical, microbial and phylogenetic aspects of photoferrotrophy, and evaluate the ecological significance of this process in ancient and modern environments. From the ferruginous conditions that prevailed during most …
Disruption of otoferlin alters the mode of exocytosis at the mouse inner hair cell ribbon synapse
2019
Sound encoding relies on Ca2+-mediated exocytosis at the ribbon synapse between cochlear inner hair cells (IHCs) and type I spiral ganglion neurons (SGNs). Otoferlin, a multi-C-2 domain protein, is proposed to regulate Ca2+-triggered exocytosis at this synapse, but the precise mechanisms of otoferlin function remain to be elucidated. Here, performing whole-cell voltage-clamp recordings of excitatory postsynaptic currents (EPSCs) from SGNs in otoferlin mutant mice, we investigated the impact of Otof disruption at individual synapses with single release event resolution. Otof deletion decreased the spontaneous release rate and abolished the stimulus-secretion coupling. This was evident from f…
On the photophysics and photochemistry of biological chromophores: An ab initio quantum chemical study
2014
La presente tesis se enmarca dentro de las líneas de investigación del grupo QCEXVAL, y en particular en el estudio de la fotofísica y fotoquímica de cromóforos de interés biológico. A continuación, se van a resumir los resultados obtenidos en los cinco trabajos publicados y presentados en esta tesis: la fotofísica de la molécula 1-aminonaftaleno, la fotofísica del cromóforo indol, el mecanismo fotoinducido de formación del fotodímero (6-4) timina-timina, el estudio y descripción crítica de la principal vía de decaimiento noradiativo en la citosina, y la respuesta del herbicida asulam frente a la radiación UVA y UVB. 1-aminonaftaleno La optimización del estado fundamental converge a una est…
Studying the stability of Solvent Red 19 and 23 as excise duty components under the influence of controlled factors
2020
Abstract In this study, we examine the chemical stability of two disazo dyes, namely Solvent Red 19 and 23 (SR 19 and SR 23), under simulated conditions. Both dyes are considered to be chemically stable under normal exploitation conditions and therefore, are used extensively as excise duty components that enable a rapid visual verification of the tax levels that were imposed on fuel products as well as identifying fuel usage. However, the results from this study confirmed that the colour of the samples that had been fortified with either SR 19 or SR 23 fades under the influence of external conditions such as UV-A irradiation and temperature over time. The UV-A irradiation was the dominant f…
Multipole strength distributions and form factors forE1,E2/E0, andE3 fromU238(e,e’f) coincidence experiments
1987
A model-independent multipole analysis of $^{238}\mathrm{U}$(e,e'f) coincidence data, taken at four momentum transfers (0.2\ensuremath{\le}${q}_{\mathrm{eff}\mathrm{\ensuremath{\le}}0.7}$ ${\mathrm{fm}}^{\mathrm{\ensuremath{-}}1}$; \ensuremath{\omega}=4--22 MeV) yields both E1, E2/E0, and E3 form factors and strength distributions. The E2/E0 strength distribution in the fission channel shows two distinct bumps centered at \ensuremath{\omega}\ensuremath{\simeq}10 and 14 MeV, exhausting up to 12 MeV (19\ifmmode\pm\else\textpm\fi{}2)% of the isoscalar E2 sum rule. The extracted form factors can be described within a hydrodynamical model by use of parameters ${c}_{\mathrm{tr}/{c}_{0}=1.2}$ and …
Study of three-nucleon mechanisms in the photodisintegration of 3He
1997
Abstract The cross section of the 3He(γ,pp)n reaction has been measured for the first time over a wide photon energy and proton angular range (200 MeV ≤ Eγ ≤ 800 MeV; 20° ≤ ϑplab ≤ 160°) using the large acceptance detector DAPHNE at the tagged photon facility of the MAMI microtron in Mainz. The wide kinematical coverage of the measurement has allowed a detailed analysis of three-nucleon absorption mechanisms. A model developed by Laget explains the main characteristics of the data in the Δ resonance region.
Essential of audiology: screening and postscreening
2014
Newborn hearing screening is a type of screening testfor the early detection of hearing loss. It can recognizewith good accuracy newborns affected by hearingimpairment allowing an early diagnosis and interventionand avoiding cognitive and linguistic deficits [1-6].The incidence of bilateral sensorineural hearing loss(SNHL) in Sicily is 2.35 cases per 1000 newborns; thisvalue increases to 2.95 if we consider also unilateral SNHL[2,3] and to 10 cases per 1000 births among infants at risk[7-9].A correct newborn hearing screening programme isbased on different protocols depending on the presence/absence of audiologic risk factors:† Newborns without risk factors: [1-3]Initial Hearing Screening (…
Photofission of235U and238U at intermediate energies: absolute cross sections and fragment mass distributions
1994
The total photofission cross section σγ,F for235U and238U has been measured in the energy range 50≤E γ≤800 MeV at the 855 MeV Mainz Microtron MAMI using energy and time tagged photons (Glasgow Tagger) and a 4π arrangement of position sensitive fragment detectors. Besides the absolute photofission cross section σγF , which almost completely exhausts the total photon absorption cross section for these nuclei, fragment mass distributions in this energy domain were determined via time of flight techniques (TOF). The results for the total photofission cross sections σγ,F normalized to the atomic numberA for both isotopes coincide, and agree in theΔ-resonance region, within the systematic errors,…
Total photofission cross section for 238U as a substitute for the photon absorption cross section in the energy range of the first baryon resonances
1992
Abstract The total photofission cross section σγ, F for 238U has been measured as a substitute for the total photon absorption cross section σtot in the energy range of the first baryon resonances (50⩽Eγ⩽800 MeV). The experiments were performed at the tagging facility of the new 855 MeV Mainz Microton MAMI B using monochromatic photons and a sophisticated 4π-arrangement of position sensitive fragment detectors. The measured cross section agrees in the Δ-resonance region with previous results and the so-called universal curve αtot/A. In the energy region of the D13-resonance near 710 MeV resonancelike structure could be observed as is seen for the free proton.
(e,e'f) Coincidence experiments on 235U and 238U
1990
Abstract Coincidence experiments for (e, e'f) on the actinide nuclei 235 U and 238 U have been performed at the Mainz Microtron (MAMI A) concentrating on three subjects: multipole strength distributions and form factors for the lowest multipolarities, the mass split in the fission decay of various giant multipole resonances, and the separation of near barrier fission channels. Data were taken at four values of momentum transfer ( q eff ≈ 0.20, 0.28, 0.53, and 0.71 fm −1 for 238 U, q eff ≈ 0.20, 0.44, 0.57, and 0.71 fm −1 for 235 U) for excitation energies ω = 4–22 MeV. The fission fragments have been detected using the Giessen PPAC-Ball. A model-independent multipole analysis yields both fo…