Search results for "OTR"
showing 10 items of 6791 documents
Mutations in the Cone Photoreceptor G-Protein α-Subunit Gene GNAT2 in Patients with Achromatopsia
2002
Achromatopsia is an autosomal recessively inherited visual disorder that is present from birth and that features the absence of color discrimination. We here report the identification of five independent families with achromatopsia that segregate protein-truncation mutations in the GNAT2 gene, located on chromosome 1p13. GNAT2 encodes the cone photoreceptor-specific alpha-subunit of transducin, a G-protein of the phototransduction cascade, which couples to the visual pigment(s). Our results demonstrate that GNAT2 is the third gene implicated in achromatopsia.
Reflexionsakustische Lagebestimmung von Trachealkanülen
1997
Non-invasive acoustic airway monitoring was evaluated in an experimental study. Recording amplitude and travel time of acoustic pulse response, an area-distance function of the cross sectional dimensions of the endotracheal tube and the adjacent airway was calculated to obtain an acoustic pattern of the airway. Measurements on models and excised human cadaver lungs were performed to discover whether displacement or obstruction of the artificial airway can be detected in the acoustic equivalent. Regression analysis revealed a close correlation between displacement of tracheostomy tubes and the shifting of the acoustic area-distance function (corr. coeff. 0.97-1). Dispersion analysis confirme…
A spatially resolved investigation of the local, micro-magnetic domain structure of single and polycrystalline Co2FeSi
2007
The Heusler compound Co2FeSi is a promising material for magneto-electronic devices. With a Curie temperature of 1100?K and a saturation magnetization of 6?Bohr magnetons and a high spin polarization at the Fermi edge it fulfils the essential requirements for magnetic sensors or spin valve structures. An essential feature for such devices is the micro-magnetic domain structure. X-ray magnetic circular dichroism?photo emission electron microscopy has been used for a direct observation of the domain structure of single- and polycrystalline samples. The polycrystalline material exhibits a micro-magnetic ripple structure, as it is well known for pure Co and other polycrystalline Heusler compoun…
Doubled haploid production in fruit crops
2006
The interest of fruit breeders in haploids and doubled haploids (DH), lies in the possibility of shortening the time needed to produce homozygous lines compared to conventional breeding. Haplo-diploidization through gametic embryogenesis allows single-step development of complete homozygous lines from heterozygous parents. In a conventional breeding programme, a pure line is developed after several generations of selfing. With fruit crops, characterized by a long reproductive cycle, a high degree of heterozygosity, large size, and, sometimes, self-incompatibility, there is no way to obtain haploidization through conventional methods. This paper reviews the current status of research on doub…
First Multi-wavelength Campaign on the Gamma-ray-loud Active Galaxy IC 310
2017
The extragalactic VHE gamma-ray sky is rich in blazars. These are jetted active galactic nuclei viewed at a small angle to the line-of-sight. Only a handful of objects viewed at a larger angle are known so far to emit above 100 GeV. Multi-wavelength studies of such objects up to the highest energies provide new insights into the particle and radiation processes of active galactic nuclei. We report the results from the first multi-wavelength campaign observing the TeV detected nucleus of the active galaxy IC 310, whose jet is observed at a moderate viewing angle of 10 deg - 20 deg. The multi-instrument campaign was conducted between 2012 Nov. and 2013 Jan., and involved observations with MAG…
Extended X-ray emission in PKS 1718-649
2018
PKS 1718$-$649 is one of the closest and most comprehensively studied candidates of a young active galactic nucleus (AGN) that is still embedded in its optical host galaxy. The compact radio structure, with a maximal extent of a few parsecs, makes it a member of the group of compact symmetric objects (CSO). Its environment imposes a turnover of the radio synchrotron spectrum towards lower frequencies, also classifying PKS 1718$-$649 as gigahertz-peaked radio spectrum (GPS) source. Its close proximity has allowed the first detection of extended X-ray emission in a GPS/CSO source with Chandra that is for the most part unrelated to nuclear feedback. However, not much is known about the nature …
VLBI detection of the HST-1 feature in the M87 jet at 2 cm
2010
A bright feature 80 pc away from the core in the powerful jet of M87 shows highly unusual properties. Earlier radio, optical and X-ray observations have shown that this feature, labeled HST-1, is superluminal, and is possibly connected with the TeV flare detected by HESS in 2005. It has been claimed that this feature might have a blazar nature, due to these properties. To examine the possible blazar-like nature of HST-1, we analyzed lambda 2 cm VLBA archival data from dedicated full-track observations and the 2 cm survey/MOJAVE VLBI monitoring programs obtained between 2000 and 2009. Applying VLBI wide-field imaging techniques, the HST-1 region was imaged at milliarcsecond resolution. Here …
Correlation of the highest-energy cosmic rays with nearby extragalactic objects.
2007
Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above ~ 6x10^{19} electron volts and the positions of active galactic nuclei (AGN) lying within ~ 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar…
Urinary leukotriene E4 in the assessment of nocturnal asthma
1996
Urinary leukotriene E4 (LTE4) is a marker of the body's production of cysteinyl LTs, important mediators of airway inflammation. The role of the latter in nocturnal asthma is a topic of increasing interest.This investigation was aimed at determining whether nighttime attacks are associated with increased release of LTs, expressed by urinary LTE4, and the relationship between the two phenomena.Three groups were studied: group A, seven control subjects; group B, nine asthmatic patients without nocturnal attacks; and group C, nine asthmatic patients with a comparable daytime FEV1 but who were experiencing nocturnal exacerbations (morning dips in peak expiratory flow greater than 20%). Urine wa…
Isobaric vapour–liquid equilibria for the binary systems 4-methyl-2-pentanone+1-butanol and+2-butanol at 20 and 101.3kPa
2009
Abstract Isobaric vapour–liquid equilibrium (VLE) measurements for the binary systems 4-methyl-2-pentanone + 1-butanol and 4-methyl-2-pentanone + 2-butanol are reported at 20 and 101.3 kPa. The system 4-methyl-2-pentanone + 1-butanol presents a minimum boiling point azeotrope at both pressures (20 and 101.3 kPa) and the system 4-methyl-2-pentanone + 2-butanol presents only a minimum boiling azeotrope at 20 kPa. In both systems, which deviate positively from ideal behaviour, the azeotropic composition is strongly dependent on pressure. The activity coefficients and boiling points of the solutions were correlated with its composition by the Wilson, UNIQUAC, and NRTL models for which the param…