Search results for "OTU"
showing 10 items of 2539 documents
Teprotumumab for the treatment of active thyroid eye disease
2020
Abstract Background Thyroid eye disease is a debilitating, disfiguring, and potentially blinding periocular condition for which no Food and Drug Administration–approved medical therapy is available...
Zur finnischen Rezeption von Der Besuch der alten Dame von F. Dürrenmatt
2000
Structural brain network fingerprints of focal dystonia
2019
Background: Focal dystonias are severe and disabling movement disorders of a still unclear origin. The structural brain networks associated with focal dystonia have not been well characterized. Here, we investigated structural brain network fingerprints in patients with blepharospasm (BSP) compared with those with hemifacial spasm (HFS), and healthy controls (HC). The patients were also examined following treatment with botulinum neurotoxin (BoNT). Methods: This study included matched groups of 13 BSP patients, 13 HFS patients, and 13 HC. We measured patients using structural-magnetic resonance imaging (MRI) at baseline and after one month BoNT treatment, at time points of maximal and minim…
Decreased neck muscle strength is highly associated with pain in cervical dystonia patients treated with botulinum toxin injections11No commercial pa…
2004
Abstract Hakkinen A, Ylinen J, Rinta-Keturi M, Talvitie U, Kautiainen H, Rissanen A. Decreased neck muscle strength is highly associated with pain in cervical dystonia patients treated with botulinum toxin injections. Arch Phys Med Rehabil 2004;85:1684–8. Objectives To compare the isometric neck muscle strength of cervical dystonia patients treated with botulinum toxin injections with that of healthy control subjects and to evaluate the association between neck strength, neck pain, and disability in these patients. Design Clinical cross-sectional study. Setting Outpatient rehabilitation and neurology clinics in a Finnish hospital. Participants Twenty-three patients with cervical dystonia wi…
Early entry events in Echovirus 30 infection
2020
Echovirus 30 (E30), a member of the enterovirus B species, is a major cause of viral meningitis, targeting children and adults alike. While it is a frequently isolated enterovirus and the cause of several outbreaks all over the world, surprisingly little is known regarding its entry and replication strategy within cells. In this study, we used E30 strain Bastianni (E30B) generated from an infectious cDNA clone in order to study early entry events during infection in human RD cells. E30B required the newly discovered Fc echovirus receptor (FcRn) for successful infection, but not the coxsackievirus and adenovirus receptor (CAR) or decay-accelerating factor (DAF), although an interaction with …
Evolutionary trends in arvicolids and the endemic murid Mikrotia - New data and a critical overview
2014
Abstract The study of evolutionary rates dates back to the work of Simpson and Haldane in the 1940s. Small mammals, especially Plio-Pleistocene arvicolids (voles and lemmings), are particularly suited for such studies because they have an unusually complete fossil record and exhibit significant evolutionary change through time. In recent decades, arvicolids have been the focus of intensive research devoted to the tempo and mode of evolutionary change and the identification of trends in dental evolution that can be used to correlate and date fossil sites. These studies have raised interesting questions about whether voles and lemmings had unique evolutionary trajectories, or show convergent …
Multiple morphological characters needed for field identification of cryptic long‐eared bat species around the Swiss Alps
2010
The identification of cryptic species may significantly change our view about their distribution, abundance, ecology and therefore conservation status. In the European Alps, molecular studies have revealed the existence of three sibling species of plecotine bats Plecotus auritus, Plecotus austriacus and, very recently, Plecotus macrobullaris. Knowledge of the ecological niche partitioning of cryptic species is a requisite to develop sound conservation policies. Yet, this requests the development of unambiguous identification methods easily applicable in the field. This study investigates the reliability of several morphological methods used for species recognition and proposes a new identif…
Evaluation of the “Bottleneck” Effect in an Isolated Population of Microtus hartingi (Rodentia, Arvicolinae) from the Eastern Rhodopes (Bulgaria) by …
2022
An integrative analysis of an isolated population of Harting’s vole (Microtus hartingi) from the Eastern Rhodope Mountains (Bulgaria) was carried out by morphological and morphometric methods, computed tomography, Cytb variation data, and experimental hybridization. Substantial changes in the development of the skull and teeth were found. Nevertheless, those voles can live to the senex stage. A phylogenetic reconstruction based on Cytb sequences showed that M. hartingi from the Eastern Rhodopes forms a separate clade, which is a sister clade to the voles from Northeastern Greece (also from the foothills of the Rhodopes). M. hartingi from the Rhodopes is mostly isolated reproductively …
Direct interference or indirect exploitation? An experimental study of fitness costs of interspecific competition in voles
2002
Studies on competing mammalian species in the past have focused mainly on the competitive exclusion of one species from the preferred habitat of the other. Investigations on effects of competition and coexistence on individual fitness are rare. In this study we were able to measure effects of interspecific competition on major fitness components, using a system with two vole species in asymmetric competition. Survival, reproduction and space use of bank vole Clethrionomys glareolus females were monitored in 32 enclosed populations over four replicates of eight parallel run enclosures. Into half of the enclosures we introduced an additional number of field voles Microtus agrestis, a dominant…
Examining the side effects of organizational Internet monitoring on employees
2020
PurposeInternet monitoring in organizations can be used to monitor risks associated with Internet usage and information systems in organizations, such as employees' cyberloafing behavior and information security incidents. Extant research has mainly discussed the effect of Internet monitoring in achieving the targeted goals (e.g. mitigating cyberloafing behavior and information security incidents), but little attention has been paid to the possible side effects of Internet monitoring. Drawing on affective events theory, the authors attempt to reveal that Internet monitoring may cause side effects on employees' Internet usage policy satisfaction, intrinsic work motivation and affective organ…