Search results for "OTU"
showing 10 items of 2539 documents
Atrophic dermatofibrosarcoma protuberans with the fusion gene COL1A1-PDGFB
2008
Protection Motivation Theory in Information Systems Security Research
2021
Protection motivation theory (PMT) is one of the most commonly used theories to examine information security behaviors. Our systematic review of the application of PMT in information systems (IS) security and the comparison with its application for decades in psychology identified five categories of important issues that have not yet been examined in IS security research. Discussing these issues in terms of why they are relevant and important for IS security, and to what extent IS research has not considered them, offers new research opportunities associated with the study of PMT and IS security threats. We suggest how future studies can approach each of the open issues to provide a new roa…
Ofd1, a Human Disease Gene, Regulates the Length and Distal Structure of Centrioles
2010
SUMMARYCentrosomes and their component centrioles represent the principal microtubule organizing centers of animal cells. Here we show that the gene underlying Orofaciodigital Syndrome 1, Ofd1, is a component of the distal centriole that controls centriole length. In the absence of Ofd1, distal regions of centrioles, but not procentrioles, elongate abnormally. These long centrioles are structurally similar to normal centrioles, but contain destabilized microtubules with abnormal post-translational modifications. Ofd1 is also important for centriole distal appendage formation and centriolar recruitment of the intraflagellar transport protein Ift88. To model OFD1 Syndrome in embryonic stem ce…
ANALISI FUNZIONALE DI GENI REGOLATORI DELLO SVILUPPO EMBRIONALE DI PARACENTROTUS LIVIDUS
2012
Parole chiave: TRIM, E3-ubiquitina ligasi, ectoderma orale, scheletogenesi, riccio di mare. La recente acquisizione di consistenti dati genomici ha confermato che organismi bilateri, semplici come i nematodi o complessi come l’uomo, fanno uso degli stessi strumenti di base, quali fattori di trascrizione e molecole segnale, per decodificare le informazioni necessarie allo sviluppo embrionale. Nel contesto di tali regolatori, la famiglia di proteine TRIM/RBCC (Tripartite motif/RING-Bbox-Coiled coil) rappresenta una delle principali classi di E3 ubiquitina ligasi putative, che svolgono ruoli essenziali nella regolazione di processi quali ciclo cellulare e sviluppo embrionale. Nel genoma di ric…
Noturīgo organisko piesārņotāju noteikšana Latvijas gliemenēs
2018
Noturīgo organisko piesārņotāju noteikšana Latvijas gliemenēs. Ikkere L.E., zinātniskais vadītājs Asoc. prof. Dr. chem. Vadims Bartkevičs. Maģistra darbs, 51 lappuse, 14 attēli, 11 tabulas, 74 literatūras avoti, 3 pielikumi. Latviešu valodā. Darba literatūras apskatā ir apkopota vispārīgā informācija par dažādām piesārņotāju klasēm. Izveidots plašs pārskats par pētīto piesārņotāju izplatību gliemenēs visā pasaulē, kā arī novērtēti iespējamie piesārņojuma avoti. Maģistra darbā vides piesārņojuma novērtēšanai Latvijā tika izmantotas gliemenes kā indikatororganismi. Tika analizēti divdesmit četri gliemeņu paraugi no Latvijas upēm un ezeriem. Paraugos noteiktas četras piesārņotāju grupas – poli…
Experimental studies on the detachment of multi-walled carbon nanotubes by a mobile liquid interface
2017
International audience; Retention and detachment of colloidal particles from surfaces is often considered only in terms of spontaneous chemical dispersion when the surface is already fully submerged. Nevertheless, interfacial processes, where the particles are caught on a mobile liquid contact line by capillary effects are ubiquitous. Theoretical description of such interfacial processes exist for spherical microcolloids, while for anisotropic shapes the literature is limited. Arc-discharge synthesized multiwalled carbon nanotube (MWNT) material contains besides the very anisotropic tubes also irregular amorphous carbon particles (ACP) that both are strongly hydrophobic. As a water–air–soli…
Roles for ELMOD2 and Rootletin in ciliogenesis.
2021
AbstractELMOD2 is a GTPase activating protein (GAP) with uniquely broad specificity for ARF family GTPases. We previously showed that it acts with ARL2 in mitochondrial fusion and microtubule stability and with ARF6 during cytokinesis. Mouse embryonic fibroblasts deleted for ELMOD2 also displayed changes in cilia related processes including increased ciliation, multiciliation, ciliary morphology, ciliary signaling, centrin accumulation inside cilia, and loss of rootlets at centrosomes with loss of centrosome cohesion. Increasing ARL2 activity or overexpressing Rootletin reversed these defects, revealing close functional links between the three proteins. This was further supported by the fin…
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy
2014
Macroautophagy is a degradative pathway that sequesters and transports cytosolic cargo in autophagosomes to lysosomes, and its deterioration affects intracellular proteostasis. Membrane dynamics accompanying autophagy are mostly elusive and depend on trafficking processes. RAB GTPase activating proteins (RABGAPs) are important factors for the coordination of cellular vesicle transport systems, and several TBC (TRE2-BUB2-CDC16) domain-containing RABGAPs are associated with autophagy. Employing C. elegans and human primary fibroblasts, we show that RAB3GAP1 and RAB3GAP2, which are components of the TBC domain-free RAB3GAP complex, influence protein aggregation and affect autophagy at basal an…
Synthesis of Silver Gallium Selenide (AgGaSe2) Nanotubes and Nanowires by Template-Based Electrodeposition
2020
In this work, a systematic investigation of the different parameters that control the electrodeposition processes was carried out at the aim to synthetizing AgGaSe₂ nanostructures. We found that pH is a key parameter to control both the morphology and composition of the nanostructures. Low pH favours mainly the formation of Ag2Se nanotubes with a scarce mechanical stability, while multi-phase nanowires well anchored to the substrate were obtained at higher pH. We also found that it was necessary to increase dramatically the concentration of the gallium precursor into the deposition bath in order to obtain AgGaSe₂ owing to lower redox potential of the Ga3+/Ga couple than Ag2+/Ag and Se4+/Se.…
Stepes strupastu galvas smadzeņu, galvaskausu un apakšžokļu morfometriskā mainība guentheri grupā (Arvicolinae, Sumeriomys apakšģints) ģeogrāfiskās i…
2021
Šī darba mērķis ir galvas smadzeņu, galvaskausu un apakšžokļu diverģences izpēte pēc to ģeometriskās formas, pieciem strupastu “guentheri” grupas taksoniem ar ģeometriskās morfometrijas metodes izmantošanu. Papildus bija veikta smadzeņu lineārā morfometrija. Iegūtie dati rāda, ka dzimuma faktors neietekmē izpētīto taksonu galvas smadzeņu, galvaskausu un apakšžokļu formu, kā arī galvas smadzeņu lineāros parametrus. Starp divām sugām tiek atzīmētas ievērojamas atšķirības pēc galvas smadzeņu formas (puslodes, smadzenītes un ožas sīpoli) un lineārajiem parametriem (smadzeņu augstums, platums un garums). Atšķirības tiek parādītas arī galvaskausa un apakšžokļu formā. Katram taksonam ir savas īpaš…