Search results for "OUTCOME"
showing 10 items of 5148 documents
Relapse risk after autologous transplantation in patients with newly diagnosed myeloma is not related with infused tumor cell load and the outcome is…
2006
BACKGROUND AND OBJECTIVES: This European Group for Blood and Marrow Transplantation (EBMT) multicentre randomized phase III study was designed to assess the safety and efficacy of CD34+ selection in newly diagnosed myeloma patients undergoing autologous transplantation. DESIGN AND METHODS: One hundred and eleven patients responsive to initial chemotherapy were randomized to receive CD34+ selected (arm A) or unselected PBPC (arm B) after conditioning with high-dose melphalan and TBI. ASO-PCR was used to assess purging efficacy and reinfused tumor load. Tumor load could be assessed in 59 patients. RESULTS: CD34+ selection gave a median tumor cell depletion of 2.2 logs (0.77-5.96). No tumor ce…
Essays on Employment and Unemployment Transitions
2015
The Great Recession has led to important adjustments in the labour market of most developed countries and has dramatically affected the labour market in Spain. According to the Labour Force Survey, the Spanish unemployment rate has increased drastically from 8.5% in 2006 to 25% in 2012 (see the figure). In order to understand the unemployment rate it is important to consider both entry into and exit out of unemployment. This thesis addresses relevant questions for policymakers in line with the objectives of the Europe 2020 strategy. How does the Great Recession affect the patterns and determinants of durations of unemployment and new job matches? How did gender differences in labour market …
Running faster and jumping higher? Survival and growth in international manufacturing new ventures
2018
Going international early is increasingly the choice of new ventures in manufacturing industries. However, does earliness provide a positive outcome for internationalisation? To answer this, we have longitudinally analysed 3181 manufacturing new ventures established between 2002 and 2012. Using Cox regressions, we found that the 124 late internationals had the lowest risk of failure, while the 229 early internationals could not compensate for their mortality risk with significantly higher levels of growth in the post-internationalisation period. We discuss why an early internationalisation is more perilous than beneficial and provide some suggestions for the internationalisation of new ven…
Fallzahlplanung in referenzkontrollierten Diagnosestudien
2002
Purpose: A tutorial illustration of a flexible approach to determine the sample size in reference-controlled diagnostic trials. Materials and Methods: Assuming the usual setting of a new diagnostic method to be compared with a reference method, the emphasis is on the sensitivity of the new method in comparison with the reference method, using a binary outcome (positive versus negative) for both methods. Based on the confidence interval of the sensitivity, a simple but flexible procedure for determining the sample size is described, which incorporates clinically interpretable information. The procedure is illustrated by the fictious planning of a trial to assess the diagnostic value of MRI v…
Long-Term Exposure to Transportation Noise and Risk for Type 2 Diabetes in a Nationwide Cohort Study from Denmark
2021
Background: Epidemiologic studies have linked transportation noise to increased morbidity and mortality, particularly for cardiovascular outcomes. However, studies investigating metabolic outcomes such as diabetes are limited and have focused only on noise exposures estimated for the loudest residential façade. Objectives: We aimed to examine the influence of long-term residential exposure to transportation noise at the loudest and quietest residential façades and the risk for type 2 diabetes. Methods: Road traffic and railway noise exposures (Lden) at the most and least exposed façades were estimated for all dwellings in Denmark during 1990–2017. Aircraft noise was estimated in 5-dB catego…
Saving Lives at Birth: The Impact of Home Births on Infant Outcomes
2012
Many developed countries have recently experienced sharp increases in home birth rates. This paper investigates the impact of home births on the health of low-risk newborns using data from the Netherlands, the only developed country where home births are widespread. To account for endogeneity in location of birth, we exploit the exogenous variation in distance from a mother’s residence to the closest hospital. We find that giving birth in a hospital leads to substantial reductions in newborn mortality. We provide suggestive evidence that proximity to medical technologies may be an important channel contributing to these health gains.
The effects of three remineralizing agents on regression of white spot lesions in children: A two-week, single-blind, randomized clinical trial.
2016
Background This study investigated the effect of three remineralizing agents on improving white spot lesions (WSLs). Material and Methods This clinical trial included children who had at least one WSL on anterior teeth of upper or lower jaws. The participants were randomly assigned to 4 groups by treatment: 1) a cream containing casein phosphopeptide-amorphous calcium phosphate and fluoride (MI Paste Plus); 2) a cream containing hydroxyapatite and fluoride (Remin Pro); 3) a 2% sodium fluoride gel; and 4) usual home care (control). The treatment was performed for 3 times over 10 days using special trays for retaining remineralizing agents. The area and mineral content of WSLs were measured a…
Wild-type JAK2 secondary acute erythroleukemia developing after JAK2-V617F-mutated primary myelofibrosis.
2009
A 54-year-old female patient developed acute erythroleukemia after an 8-year course of primary myelofibrosis. The latter harbors the JAK2-V617F mutation and was treated with hydroxyurea and anagrelide. A bone marrow trephine biopsy disclosed 2 morphologically distinct areas of chronic primary myelofibrosis and acute erythroleukemia. Microdissection and a separate molecular pathological analysis was performed. Although the activating JAK2-V617F mutation was not maintained in blasts of acute erythroleukemia, it was detectable in the chronic phase of primary myelofibrosis, indicating that this mutation did not play a role in the leukemic transformation of erythroid cells.
Comparison of paediatric cancers outcomes between Palermo Province (Sicily) and Southern Europe
2018
Background: Italy has one of the highest paediatric cancer incidence rate in Europe. We compared cancer incidence and survival in children (0-14 years) and adolescents (15-19 years) resident in Palermo Province with statistics derived from Italian and European surveillance systems. Methods: We included all incident cancer cases, malignant tumours and non-malignant neoplasm of central nervous system (benign and uncertain whether malignant or benign), detected in children and adolescents by the Palermo Province Cancer Registry between 2003 and 2012. A joinpoint regression model was applied. Annual Average Percentage Changes were calculated. The Besag–York–Mollie model was used to detect any c…
Management and predictors of clinical events in 75 686 patients with acute myocardial infarction
2022
Background:Although mortality of patients with acute myocardial infarction (MI) has decreased substantially over the last few decades in many countries MI remains a major threat to public health. Aims:To assess the number and outcomes of patients hospitalized for acute MI in Poland in 2018 as well as proportions of patients participating in cardiac rehabilitation and undergoing invasive cardiac procedures following discharge. Methods:We used public databases. We included all patients hospitalized for acute MI in Poland in 2018 and assessed event-free survival along with uptake of invasive cardiac procedures and cardiac rehabilitation and consultations with cardiologists. Results: A total of…