Search results for "OUTCOME"

showing 10 items of 5148 documents

Optimized threshold for serum HCV RNA to predict treatment outcomes in hepatitis C patients receiving peginterferon alfa-2a/ribavirin

2012

It is unclear whether the current threshold for 'high' hepatitis C virus (HCV) RNA level (800,000 IU/mL) is optimal for predicting sustained virological response (SVR). We retrospectively analysed pretreatment HCV RNA levels and SVR rates in 1529 mono-infected and 176 HIV-HCV co-infected patients treated with peginterferon alfa-2a (40 kD) plus ribavirin. We improved the threshold for differentiating low and high viral load by fitting semiparametric generalized additive logistic regression models to the data and constructing receiver operating characteristics curves. Among HCV genotype 1 mono-infected patients, the difference in SVR rates between those with low and high baseline HCV RNA leve…

AdultMaleInterferon-alphaAlanine TransaminaseHepacivirusMiddle AgedViral LoadAntiviral AgentsHepatitis CRecombinant ProteinsPolyethylene GlycolsLogistic ModelsTreatment OutcomeROC CurveRibavirinHumansRNA ViralDrug Therapy CombinationFemalehepatitis CRetrospective Studies
researchProduct

Safety and tolerability of slow-release oral morphine versus methadone in the treatment of opioid dependence

2014

Opioid substitution treatment (OST) for opioid dependence may be limited by adverse events (AEs). Increasing the range of therapeutic options optimizes outcomes and facilitates patient management. An international, multi-center, two-phase study investigated the efficacy and safety of slow-release oral morphine (SROM) versus methadone in patients receiving methadone therapy for opioid dependence. In phase 1 (two way cross-over, 11 weeks each period) patients were randomized to SROM or methadone oral solution. In phase 2 (25 weeks), patients continued treatment with SROM (group A) or switched from methadone to SROM (group B). In total, 211 out of 276 completed phase 1 and 198 entered phase 2 …

AdultMaleInternational CooperationAdministration OralMedicine (miscellaneous)QT intervalHeroinOpiate Substitution TreatmentHumansMedicineIn patientOral morphineAdverse effectCross-Over StudiesMorphinebusiness.industryOpioid-Related DisordersEuropePsychiatry and Mental healthClinical PsychologyTreatment OutcomeOpioidTolerabilityDelayed-Action PreparationsAnesthesiaFemalePshychiatric Mental HealthbusinessMethadonemedicine.drugMethadoneJournal of Substance Abuse Treatment
researchProduct

Combined procedure for glaucoma and cataract: A retrospective study

1994

Abstract To ascertain the long-term effects of a triple procedure in the case of coexisting cataract and glaucoma, we did a retrospective study of 93 eyes that had cataract extraction, IOL implantation, and trabeculectomy within a ten-year period. Mean follow-up was 32.4 ± 21.9 months. Mean postoperative intraocular pressure (IOP) was significantly lower than preoperatively, even though fewer medications were being used. One year after surgery, 60% of eyes had a best corrected visual acuity of 20/40 or better with an average improvement of 3.8 Snellen lines. Patients who had had surgery four or more years before the study had the highest percentage of eyes with an IOP exceeding 22 mm Hg. Th…

AdultMaleIntraocular pressuremedicine.medical_specialtyAdolescentgenetic structuresmedicine.medical_treatmentEye diseaseVisual AcuityGlaucomaTrabeculectomyIntraocular lensCataract ExtractionOphthalmologymedicineHumansTrabeculectomyLongitudinal StudiesIntraocular PressureAgedRetrospective StudiesAged 80 and overLenses IntraocularBest corrected visual acuitybusiness.industryGlaucomaRetrospective cohort studyCombined procedureMiddle Agedmedicine.diseaseeye diseasesSensory SystemsSurgeryOphthalmologyTreatment OutcomeFemaleSurgerysense organsbusinessFollow-Up StudiesJournal of Cataract and Refractive Surgery
researchProduct

Medium-term visual, refractive, and intraocular stability after implantation of a posterior chamber phakic intraocular lens to correct moderate to hi…

2011

To evaluate the medium-term refractive and visual outcomes and the complications after implantation of a silicone posterior chamber phakic intraocular lens (PC pIOL) for moderate to high myopia.Oftalmar, Medimar International Hospital, Alicante, Spain.Retrospective case series.Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, and intraocular pressure were evaluated during a medium-term follow-up. Postoperative complications were also studied.The study enrolled 35 eyes (mean preoperative spherical equivalent [SE] -10.25 diopters [D] ± 3.19 [SD]) of 20 patients with a mean age of 31.83 ± 8.87 years and a mean follow-up of 57.34 ± 9.24 months. The mean UDVA improved…

AdultMaleIntraocular pressuremedicine.medical_specialtyPhakic Intraocular LensesVisual acuitygenetic structuresVisual AcuityPhakic intraocular lensRefraction OcularMedium termYoung AdultPostoperative ComplicationsLens Implantation IntraocularOphthalmologyMedicineHumansDioptreIntraocular PressureRetrospective Studiesbusiness.industryHigh myopiaPosterior Eye SegmentMiddle AgedRefractioneye diseasesSensory SystemsPosterior chamber phakic intraocular lensOphthalmologyTreatment OutcomeMyopia DegenerativeSurgeryFemalemedicine.symptombusinessFollow-Up StudiesJournal of cataract and refractive surgery
researchProduct

A new approach based on Machine Learning for predicting corneal curvature (K1) and astigmatism in patients with keratoconus after intracorneal ring i…

2014

Keratoconus (KC) is the most common type of corneal ectasia. A corneal transplantation was the treatment of choice until the last decade. However, intra-corneal ring implantation has become more and more common, and it is commonly used to treat KC thus avoiding a corneal transplantation. This work proposes a new approach based on Machine Learning to predict the vision gain of KC patients after ring implantation. That vision gain is assessed by means of the corneal curvature and the astigmatism. Different models were proposed; the best results were achieved by an artificial neural network based on the Multilayer Perceptron. The error provided by the best model was 0.97D of corneal curvature …

AdultMaleKeratoconusgenetic structuresComputer sciencemedicine.medical_treatmentHealth InformaticsAstigmatismMachine learningcomputer.software_genreKeratoconusCorneal TransplantationMachine LearningYoung AdultCorneal ectasiaIntracorneal ringsArtificial IntelligenceProsthesis FittingmedicineHumansIn patientCorneal transplantationAgedRing (mathematics)Corneal curvaturebusiness.industryCorneal TopographyAstigmatismProstheses and ImplantsMiddle AgedDecision Support Systems ClinicalPrognosismedicine.diseaseeye diseasesComputer Science ApplicationsPatient Outcome AssessmentTreatment OutcomeFemalesense organsArtificial intelligencebusinesscomputerLENGUAJES Y SISTEMAS INFORMATICOSSoftware
researchProduct

Uncommon clinical presentation of Kimura’s disease as bilateral retroauricular masses in a young Malian male: successful surgical approach.

2016

We present a case of a 27 year-old Malian male referred to our hospital for two large, painless retroauricolar masses that had appeared two years earlier. Bilateral cervical painless lymphadenopathy was present at physical examination, without any other systemic symptoms. His history was relevant for bilateral Kimura’s disease lesions resected 5 years earlier in the same locations. Lymphocytosis and a mild hypereosinophilia were found in routine blood tests, together with increased total IgE levels. After surgery, histology showed lymphoid infiltrates with reactive prominent germinal centres containing eosinophils, suggesting relapse of Kimura’s disease, in the context of nonencapsulated fi…

AdultMaleKimura diseaseCancer ResearchPhysiologyEndocrinology Diabetes and MetabolismImmunologyAngiolymphoid Hyperplasia with EosinophiliaNon-AsianFibrosisKeloid Kimura disease neck retroauricolar non-AsianTreatment OutcomeEndocrinologyOncologyRecurrenceKeloidPhysiology (medical)retroauricolarHumansImmunology and AllergyRetroauricularNeck
researchProduct

Endoluminal therapy of GERD with a new endoscopic suturing device

2005

Background Endoscopic, endoluminal therapy might be an alternative treatment option in light of the costs of proton pump inhibitor therapy and possible complications after laparoscopic surgery. The aim of the current study was to assess the efficacy and the safety of a new endoluminal suture device (ESD) in pig models and humans. Secondly, 3 and 6 months' follow-ups were performed, and possible complications and their management were evaluated. Methods In the preclinical phase of the study, suturing procedures were practiced and evaluated in 8 pig models (Erlanger Endo Trainer). In the clinical phase, 20 patients with mild esophagitis, small or no hiatal hernia, and signs of abnormal acid e…

AdultMaleLaparoscopic surgerymedicine.medical_specialtyAdolescentEndoscopeManometrySwineSedationmedicine.medical_treatmentEndoscopy GastrointestinalGastric AcidHiatal herniaEsophagusPressuremedicineAnimalsHumansRadiology Nuclear Medicine and imagingmedicine.diagnostic_testbusiness.industrySuture TechniquesGastroenterologyEquipment DesignHydrogen-Ion Concentrationmedicine.diseaseEndoscopySurgeryDisease Models AnimalTreatment OutcomeTherapeutic endoscopyGastroesophageal RefluxGERDFemalemedicine.symptombusinessEsophagitisFollow-Up StudiesGastrointestinal Endoscopy
researchProduct

Predictors of weight loss after an intensive lifestyle intervention program in obese patients: a 1-year prospective cohort study.

2013

Published Version of an article in the journal: Health and Quality of Life Outcomes. Also available from the publisher at: http://dx.doi.org/10.1186/1477-7525-11-165 Open access Background Studies of lifestyle intervention programs in morbid obesity report large variations in weight loss outcomes. This is reported not only between but also within standardized programs. Such reports point to participants’ characteristics as possible predictors of this outcome. The aim of this prospective cohort study was to identify predictors of weight loss after a 1-year partly residential intensive lifestyle intervention program (ILI). Methods Morbidly obese patients (n=199), all Caucasian, 71% women, mea…

AdultMaleLifestyle interventionmedicine.medical_specialtyWeight lossType 2 diabetesCohort StudiesMorbid obesityQuality of lifeWeight lossInternal medicineOutcome Assessment Health CaremedicineHumansHealth related quality of lifeProspective StudiesProspective cohort studyLife Stylebusiness.industryNorwayPredictorsResearchPublic Health Environmental and Occupational HealthGeneral MedicineVDP::Medical disciplines: 700::Health sciences: 800AnthropometryMiddle Agedmedicine.diseaseObesityCombined Modality TherapyObesity MorbidPhysical therapyLinear ModelsFemalemedicine.symptombusinessBody mass indexRisk Reduction BehaviorCohort studyForecastingHealth and quality of life outcomes
researchProduct

Web Support for weight-loss interventions: PREDIRCAM2 clinical trial baseline characteristics and preliminary results

2018

An ongoing clinical trial is testing the efficacy of web telematic support in a structured program for obesity treatment and diabetes prevention. Participants were recruited from two tertiary-care hospitals and randomized to receive either a telematic intervention (TI) supported by PREDIRCAM2 web platform or a non-telematic intervention (NTI). All receive 1-year follow-up. Both interventions consist of tailored dietary and exercise prescriptions, based on a Mediterranean dietary pattern and general WHO exercise recommendations for adults. At 6 months, both groups have received 7 contacts, 3 exclusively telematic for the TI group. This is a preliminary result intention-to-treat analysis. One…

AdultMaleLifestyle modificationmedicine.medical_specialtyTelemedicine020205 medical informaticsMedicinaEndocrinology Diabetes and Metabolism02 engineering and technologyDiet MediterraneanBody Mass Index03 medical and health sciences0302 clinical medicineEndocrinologyLifestyle modificationDiabetes mellitusWeight Loss0202 electrical engineering electronic engineering information engineeringmedicineHumans030212 general & internal medicineHealthy LifestyleObesityExercise2. Zero hungerTelecomunicacionesbusiness.industryMiddle Agedmedicine.diseaseObesityMetabolic syndromeTelemedicine3. Good healthClinical trialMedical Laboratory TechnologyTreatment OutcomeWeight loss interventionsBaseline characteristicsPhysical therapyFemaleElectrónicaMetabolic syndromebusiness
researchProduct

Weekly Dose-Dense Cisplatin-Epirubicin-Paclitaxel Administration with Granulocyte Colony-Stimulating Factor Support Does Not Substantially Improve Pr…

2004

Purpose: The present study was aimed at defining the antitumor activity of the cisplatin-epirubicin-paclitaxel (PET) weekly administration with granulocyte colony-stimulating factor (G-CSF) support in chemonaive small-cell lung cancer patients with extensive disease (ED-SCLC). Methods: Chemonaive ED-SCLC patients received cisplatin 30 mg/sqm, epirubicin 50 mg/sqm and paclitaxel 120 mg/sqm, weekly, with G-CSF (5 μg/kg from day 3 to 5) support, for a maximum of 12 weeks. Results: Thirty-nine patients were treated, for a total of 354 cycles delivered. Eight complete (21%), and 22 partial responses (56%) were recorded, giving a 77% (95% Cl = 61-89%) objective response rate (ORR). After 14 (rang…

AdultMaleLung NeoplasmsPaclitaxelMiddle AgedPrognosisSmall-cell lung cancer Weekly chemotherapy Paclitaxel Epirubicin CisplatinSurvival AnalysisDrug Administration ScheduleTreatment OutcomeAntineoplastic Combined Chemotherapy ProtocolsGranulocyte Colony-Stimulating FactorHumansFemaleCarcinoma Small CellCisplatinInfusions IntravenousAgedEpirubicin
researchProduct