Search results for "Octanols"
showing 4 items of 4 documents
Rapid in vitro test to predict ocular tissue permeability based on biopartitioning micellar chromatography.
2003
The drug permeability prediction across the ocular tissues is important in the development of new drugs and drug delivery strategies. Physicochemical characteristics of drugs, mainly acid-base character, hydrophobicity and the molecular size determine both their transport across the eye tissue barriers and their retention in biopartitioning micellar chromatography (BMC). An in vitro model able to describe and predict the whole cornea drug permeability is proposed. The model uses the retention of drugs in BMC and molecular weight (MW) as predictive variables. The relationships between drug retention data in BMC and their bibliographic permeability values in stroma, epithelium-plus-stroma and…
Solid lipid nanoparticles containing tamoxifen characterization and in vitro antitumoral activity.
2005
Solid lipid nanoparticles (SLNs) containing tamoxifen, a nons- teroidal antiestrogen used in breast cancer therapy, were prepared by microemulsion and precipitation techniques. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration, and in vitro plasmatic drug release studies demon- strated that these systems are able to give a prolonged release of the drug in the intact form. Preliminary study of antiproliferative ac- tivity in vitro, carried out on MCF-7 cell line (human breast cancer cells), demonstrated that SLNs, containing tamoxifen showed an antitumoral activity comparable to free drug. The results of char- acterization studies and of in vitro …
Micellar versus hydro-organic mobile phases for retention-hydrophobicity relationship studies with ionizable diuretics and an anionic surfactant
2004
Abstract Logarithm of retention factors (log k ) of a group of 14 ionizable diuretics were correlated with the molecular (log P o/w ) and apparent (log P app ) octanol–water partition coefficients. The compounds were chromatographed using aqueous–organic (reversed-phase liquid chromatography, RPLC) and micellar–organic mobile phases (micellar liquid chromatography, MLC) with the anionic surfactant sodium dodecyl sulfate (SDS), in the pH range 3–7, and a conventional octadecylsilane column. Acetonitrile was used as the organic modifier in both modes. The quality of the correlations obtained for log P app at varying ionization degree confirms that this correction is required in the aqueou…
Behaviour-modifying compounds for management of the red palm weevil (Rhynchophorus ferrugineus Oliver).
2014
BACKGROUND: Populations of red palm weevil (RPW), a severe pest of palms in Mediterranean countries, might be limited by semiochemical-based behaviour-disrupting methods. We evaluated the effects of electroantennogram (EAG)-active plant volatiles on the behaviour of RPWs from Italy and Israel. In field experiments, α-pinene, citronellol, geraniol, citral and 1-octen-3-ol were tested for their ability to disrupt attraction to pheromone-kairomone and molasses baited traps. Those that were found to be disruptive in the field were evaluated in a laboratory choice bioassay in individual cages for their effect on RPW female feeding and oviposition. RESULTS: Field experiments showed reduced captur…