Search results for "Offspring"
showing 10 items of 395 documents
Prenatal manganese serum levels and neurodevelopment at 4 years of age
2020
Abstract Background The excess of manganese (Mn) causes severe deleterious effects in the central nervous system, and the developing brain is especially sensitive to Mn overload. However, results of prospective studies regarding Mn neurodevelopmental effects remain inconclusive. The present study aims at studying the association of prenatal Mn exposure and neurodevelopment at 4–5 years of age. Methods: Mn serum concentration was measured in 1465 pregnant women from the INMA (INfancia y MedioAmbiente, Environment and Childhood) Project. Neurodevelopment was assessed using a standardized version of the McCarthy Scales of Children's Abilities (MSCA). Multivariate regression models were used fo…
Centenarian offspring: A model for understanding healthy aging
2018
Centenarians exhibit extreme longevity showing a compression of morbidity. We showed previously that microRNA expression profiles and plasma protein carbonylation in centenarians and young people are similar, whereas they are very different from that found in old individuals. This suggests that centenarians have a better control of homeostasis and are protected against oxidative damage. In this study, we aimed to determine if such characteristic microRNA expression profile and lower protein oxidation status in centenarians may be inherited by their offspring. For this purpose, we collected plasma and peripheral blood mononuclear cells from 90 septuagenarians, 68 centenarians and 46 centenar…
Caregiving increases health complaints in middle-aged caregivers of autistic offspring: the role of years caring
2011
IntroductionCaregiving of offspring with a chronic illness is a highly stressful vital experience. Previous studies with parents of schizophrenic persons revealed that these situations increase health complaints (González-Bono et al., 2009), with the duration of caring being a relevant variable (Contell-Montaña et al., 2010). The higher age of the caregivers of schizophrenia can contribute to this health unbalance, but little is known in younger samples.Aim/objectiveTo test whether middle-aged caregivers (parents of autistic persons) present higher health disturbances than controls and to investigate the moderating role of duration of caringMethodsHealth complaints and resting levels of imm…
n-3 Fatty Acids Modulate T-Cell Calcium Signaling in Obese Macrosomic Rats
2004
Objective: We investigated the effects of a diet containing EPAX-7010, rich in PUFAs such as eicosapentaenoic acid [20:5(n-3)] and docosahexaenoic acid [22:6(n-3)], i.e., a PUFA/EPAX regimen, on T-cell activation in diabetic pregnant rats and their obese pups. Research Methods and Procedures: Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin on Day 5 of gestation. T-cell blastogenesis was assayed by using 3H-thymidine, whereas intracellular free calcium concentrations ([Ca2+]i) were measured by using Fura-2 in diabetic pregnant rats and their obese offspring. Results: Concavalin-A-stimulated T-cell proliferation was decreased in both pregnant dia…
Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding
2015
Epidemiological observations report an increase in fat consumption associated with low intake of n-3 relative to n-6 polyunsaturated fatty acids (PUFAs) in women of childbearing age. However, the impact of these maternal feeding habits on cognitive function in the offspring is unknown. This study aims to investigate the impact of early exposure to a high-fat diet (HFD) with an unbalanced n-6/n-3 PUFAs ratio on hippocampal function in adult rats. Furthermore, we explored the effects of perinatal HFD combined with exposure to HFD after weaning. Dams were fed a control diet (C, 12% of energy from lipids, n-6/n-3 PUFAs ratio: 5) or HFD (HF, 39% of energy from lipids, n-6/n-3 PUFAs ratio: 39) th…
Obstetric and offspring risks of women’s morbid conditions linked to prior anticancer treatments
2016
Background Literature shows the effects of type of cancer and/or anticancer treatment on live birth percentages and/or pregnancy and neonatal complications in female cancer survivors. However, studies analyzing the obstetric and offspring risks of the morbid conditions associated with previous anti-cancer treatments are missing. The present review aims to uncover these risks. Methods A literature search based on publications up to March 2016 identified by PubMed and references cited in relevant articles. Results The morbid conditions associated with prior anticancer treatments including chemotherapy, radiotherapy, surgery, and/or hematopoietic stem-cell transplant may induce not only obstet…
Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes.
2001
The aim of this study was to determine the impact of diabetic macrosomia on cholesterol and lipoprotein metabolism. Age-related changes in the activities of serum LCAT, hepatic HMG-CoA reductase, cholesterol 7α-hydroxylase, and ACAT, the major enzymes involved in cholesterol metabolism, were determined in macrosomic offspring of streptozotocin-induced diabetic rats. Hepatic, serum, and lipoprotein cholesterol contents were also examined. Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At birth, macrosomic pups had higher serum, LDL-HDL1, and H…
67 The effect of hypertensive disorders of pregnancy on the risk of attention-deficit/hyperactivity disorder in the offspring
2016
Introduction Attention-deficit/hyperactivity disorder (ADHD) is a frequent neurodevelopmental disorder. Inadequate placentation as a result of hypertensive disorders of pregnancy has been proposed to be a central mechanism of fetal neurodevelopmental comprise. Recently it has been shown that pre-eclampsia increases the risk of ADHD [Mann and McDermott, 2011] . Objectives We examined the association between hypertensive disorders of pregnancy and ADHD and behavioural difficulties among 7-year old children. We also examined whether circulating factors in serum from women with a HDP alter early patterns of fetal neural growth. Methods The study cohort consisted of 13,192 children (weighted = 1…
La nutrición en el periodo preconcepcional y los resultados del embarazo: revisión bibliográfica y propuesta de intervención del Dietista-Nutricionis…
2016
El estado nutricional de la madre antes y durante el embarazo se constata en los últimos años como uno de los factores ambientales más influyentes en el desarrollo fetal. Este estudio se centra en las primeras fases del proceso de gestación o periodo periconcepcional: preconcepción, concepción, implantación, placentación y embriogénesis; puesto que representan un paso crítico en los resultados del embarazo. Tras una revisión bibliográfica exhaustiva de 66 investigaciones publicadas entre los años 1990 y 2015, fueron el zinc, el hierro, el yodo, los ácidos grasos omega-3, el ácido fólico y otras vitaminas del grupo B, los minerales y micronutrientes para los que se han encontrado mayor evide…
Investigation and management of Toxoplasma gondii infection in pregnancy and infancy: a prospective study.
2011
Aim:Toxoplasma gondii infection during pregnancy poses a serious risk to the fetus, therefore timely and accurate diagnosis is essential. The aim of this study was to estimate the frequency of congenital infection via evaluating mother's immunological status and the possibility to improving the diagnostic and therapeutic approaches.Methods:Eighty five mothers with Toxoplasma seroconversion and their offspring were enrolled (among them, 2 spontaneous abortions were documented in the first trimester). Prenatal PCR diagnosis was carried out on 50 patients (60%), with 7 positive cases (14%). Morphological ultrasound scanning revealed anomalies in one fetus. Long-term follow-up included general …