Search results for "Ofili"
showing 10 items of 996 documents
La consulenza tributaria in Sicilia al femminile: scenario attuale e futuro
2007
La partecipazione della donna al mercato del lavoro risulta ancora marginale, anche in riferimento al ruolo che essa ricopre nelle regioni del Centro-Nord dell'Italia. Gli indicatori comunemente calcolati mettono in rilievo le difficoltà di inserimento delle donne siciliane nel contesto socio-economico regionale. L'opportunità di formazione offerta dal progetto Minerva incoraggia la componente femminile ad intraprendere attività lavorative tradizionalmente riservate alla componente maschile della forza lavoro.
La scuola e il senso delle sue riforme fra i paria e i parvenu del nostro tempo
2002
Il saggio riesamina criticamente gli effetti del "Riordino dei cicli scolastici" (legge quadro n. 30/00) nei suoi articoli pi problematici (artt. 1 e 3 ), formulando un ipotesi applicativo-procedurale nella didattica dei curricula e negli aspetti formativi dei profili in uscita della popolazione scolastica degli istituti di secondo grado.
miRNA Signature and Dicer Requirement during Human Endometrial Stromal Decidualization In Vitro
2012
Decidualization is a morphological and biochemical transformation of endometrial stromal fibroblast into differentiated decidual cells, which is critical for embryo implantation and pregnancy establishment. The complex regulatory networks have been elucidated at both the transcriptome and the proteome levels, however very little is known about the post-transcriptional regulation of this process. miRNAs regulate multiple physiological pathways and their de-regulation is associated with human disorders including gynaecological conditions such as endometriosis and preeclampsia. In this study we profile the miRNAs expression throughout human endometrial stromal (hESCs) decidualization and analy…
Differentiating Multiple Sclerosis From AQP4-Neuromyelitis Optica Spectrum Disorder and MOG-Antibody Disease With Imaging.
2023
Background and ObjectivesRelapsing-remitting multiple sclerosis (RRMS), aquaporin-4 antibody–positive neuromyelitis optica spectrum disorder (AQP4-NMOSD), and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) may have overlapping clinical features. There is an unmet need for imaging markers that differentiate between them when serologic testing is unavailable or ambiguous. We assessed whether imaging characteristics typical of MS discriminate RRMS from AQP4-NMOSD and MOGAD, alone and in combination.MethodsAdult, nonacute patients with RRMS, APQ4-NMOSD, and MOGAD and healthy controls were prospectively recruited at the National Hospital for Neurology and Neurosurgery (L…
Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma
2020
AbstractCutaneous melanoma is an aggressive neoplasm and is responsible for the majority of skin cancer deaths. Several miRNAs are involved in melanoma tumor progression. One of them is miR-205, the loss of which contributes to the development of melanoma metastasis. We evaluated whole-genome mRNA expression profiling associated with different miR-205 expression levels in melanoma cells. Differential expression analysis identified 243 differentially expressed transcripts including inositol polyphosphate 5′-phosphatase-like protein-1 (INPPL1) and BTB/POZ Domain-Containing Protein 3 (BTBD3). INPPL1 and BTBD3 were downregulated when melanoma cells expressed miR-205, indicating that these genes…
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
2014
Mutations in the cytosine-5 RNA methyltransferase NSun2 cause microcephaly and other neurological abnormalities in mice and human. How post-transcriptional methylation contributes to the human disease is currently unknown. By comparing gene expression data with global cytosine-5 RNA methylomes in patient fibroblasts and NSun2-deficient mice, we find that loss of cytosine-5 RNA methylation increases the angiogenin-mediated endonucleolytic cleavage of transfer RNAs (tRNA) leading to an accumulation of 5' tRNA-derived small RNA fragments. Accumulation of 5' tRNA fragments in the absence of NSun2 reduces protein translation rates and activates stress pathways leading to reduced cell siz…
Smartphone Usage Among Millennial in Finland and Implications for Marketing Segmentation Strategies: Lessons for Nigeria
2018
The study examines smart phone usage by millennials based on different criteria of operating system, Wi-Fi, text messaging, internet surfing and social media. The study used quantitative methodology and data were gathered with online questionnaires with 391 young smartphone users in Finland. The Millennial were clustered into five levels. The results reveal the prominent status of profiling in a developed market and how marketers in emerging markets can apply segmentation and targeting strategies using instant messaging, text messages, email, mobile app, gamification and social media based on the profile of each segment. Nigerian policy makers should adopt a framework to make smartphone aff…
Adolescents' engagement profiles and their association with academic performance and situational engagement
2020
Abstract This study examined adolescents' engagement profiles and their association with situational engagement and academic performance in lower secondary school settings. The data consisted of 301 Grade 7 students from Finland. By utilizing person-oriented approach with Latent Profiling Analysis on subscales capturing students' overall engagement, four subgroups of students with different overall engagement profiles were identified. These profile groups were further analyzed with respect to differences in student background (gender and maternal education), academic performance (GPA, and reading and mathematics tests), and lesson-specific situational engagement. The profile groups showed d…