Search results for "Ofili"

NOSIP, a novel modulator of endothelial nitric oxide synthase activity.

2001

Production of nitric oxide (NO) in endothelial cells is regulated by direct interactions of endothelial nitric oxide synthase (eNOS) with effector proteins such as Ca2+-calmodulin, by posttranslational modifications such as phosphorylation via protein kinase B, and by translocation of the enzyme from the plasma membrane caveolae to intracellular compartments. Reversible acylation of eNOS is thought to contribute to the intracellular trafficking of the enzyme; however, protein factor(s) that govern the translocation of the enzyme are still unknown. Here we have used the yeast two-hybrid system and identified a novel 34 kDa protein, termed NOSIP (eNOS interacting protein), which avidly binds …

A data-logging mechanism to support e-learning systems

2015

User profiling and e-learning have received great attention in the last years. In a learning environment, user profiling provides historical data of the students' performance on different learning subjects. e-Learning tools such as serious games can collect user's data and build a user profile by appropriate storing these information. Thus, by combining above techniques and analysing each user's data a teacher can provide personalized treatment to her/his students. In this paper we present our solution on storing and analysing user data on a centralized server. Our system stores data collected from users with dyslexia. We maintain one user profile per student from data taken from a) user re…

Human Papilloma Virus-Dependent HMGA1 Expression Is a Relevant Step in Cervical Carcinogenesis

2008

HMGA1 is a member of a small family of architectural transcription factors involved in the coordinate assembly of multiprotein complexes referred to as enhanceosomes. In addition to their role in cell proliferation, differentiation, and development, high-mobility group proteins of the A type (HMGA) family members behave as transforming protoncogenes either in vitro or in animal models. Recent reports indicated that HMGA1 might counteract p53 pathway and provided an interesting hint on the mechanisms determining HMGA's transforming potential. HMGA1 expression is deregulated in a very large array of human tumors, including cervical cancer, but very limited information is available on the mole…

Autocrítica de un amor

2008

La violenza indicibile. l'aggressività femminile nelle relazioni interpersonali

2012

L’espressione della violenza nelle relazioni familiari è da alcuni anni oggetto di interesse in ambito sociologico, psicologico e giuridico. Le riflessioni teoriche e gli studi empirici sul tema hanno dato ampio spazio prevalentemente all’esercizio di violenza da parte dell’uomo lasciando sullo sfondo altre tipologie di relazioni disfunzionali ove la violenza viene invece perpetrata dalla donna. L'aggressività femminile è, invece, tutt'altro che rara, e se esiste un generale consenso sul fatto che gli uomini mostrino livelli più elevati di aggressione fisica rispetto alle donne, è pur vero che le differenze risultano essere piccole e moderate, evidenziando che anche le donne possono essere …

Discovering Homophily in Online Social Networks

2018

During the last ten years, Online Social Networks (OSNs) have increased their popularity by becoming part of the real life of users. Despite their tremendous widespread, OSNs have introduced several privacy issues as a consequence of the nature of the information involved in these services. Indeed, the huge amount of private information produced by users of current OSNs expose the users to a number of risks. The analysis of the users’ similarity in OSNs is attracting the attention of researchers because of its implications on privacy and social marketing. In particular, the homophily between users could be used to reveal important characteristics that users would like to keep hidden, hence …

Transcriptional Upregulation of Genes Related to Virulence Activation in Entamoeba histolytica

2007

Background To understand the molecular basis of virulence variability in Entamoeba histolytica , this study presents results about differential gene expression induced by E. histolytica trophozoites in liver of hamsters in order to produce experimental amebic liver abscess (ALA) and consequently reactivate its virulence. Methods Amebic cultures were studied before (BALA) and after (AALA) inoculation in hamster peritoneal cavity. Markers of pathogenicity such as the rate of erythrophagocytosis, hemolytic activity, and cytotoxic effects on MDCK cell monolayers were evaluated in order to correlate these phenotypic characteristics to differential gene expression between virulent and non-virulen…

Profili psicologici e strategie difensive in donne affette da Vulvodinia

A sequence motif enriched in regions bound by the Drosophila dosage compensation complex

2010

Abstract Background In Drosophila melanogaster, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood. Characteristic sequence signatures at all DCC binding sites have not hitherto been found. Results In this study, we compare the known binding sites of the DCC with oligonucleotide profiles that measure the specificity of the sequences of the D. melanogaster X chromosome. We show that the X chromosome regions bound by the DCC are enriched for a particular type of short, repetitive sequences. Their distribution suggests that these sequences contribute to chromosome recognition, the genera…

Global patterns of sequence evolution in Drosophila.

2007

This article is available from: http://www.biomedcentral.com/1471-2164/8/408