Search results for "Oleanolic Acid"
showing 3 items of 63 documents
Biologically and Pharmacologically Active Saponins from Plants: Recent Advances
2000
Saponins as triterpene or steroid glycosides were well known in ancient times for their detergent, haemolytic and fish toxic activities, properties which are correlated with the amphiphilic character of the molecules and their ability to complex cholesterol.
Harmful and Protective Effects of Terpenoids from African Medicinal Plants
2014
Terpenoids represent the most widespread group of natural products and can be found in all classes of living things. Many defensive compounds include sesquiterpenoids and diterpenoids from angiosperm species. Several terpenoids are biologically active and are exploited in the fight against cancer, malaria, inflammation, and a variety of infectious diseases. Nonetheless, some compounds of this group showed toxic effects causing gastrointestinal problems or central nervous system manifestations among others. Several bioactive terpenoids were identified in African medicine with numbers of them having organ-protective effects while few are known for their nonbeneficial properties for humans. In…
Inhibition of the NF-κB Signaling Pathway Mediates the Anti-inflammatory Effects of Petrosaspongiolide M
2003
Petrosaspongiolide M (PT) is a potent secretory phospholipase A(2) inhibitor and anti-inflammatory agent. This marine metabolite reduced the production of nitrite, prostaglandin E(2), and tumor necrosis factor-alpha in the mouse air pouch injected with zymosan. These effects were also observed in mouse peritoneal macrophages stimulated with zymosan. Inhibition of these inflammatory mediators was related to reductions in inducible nitric oxide synthase, cyclo-oxygenase-2, and tumor necrosis factor-alpha expression. Since nuclear factor-kappaB (NF-kappaB) appears to play a central role in the transcriptional regulation of these proteins by macrophages, we investigated the effects of PT on thi…