Search results for "Oleoylethanolamide"

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The identification of peroxisome proliferator-activated receptor alpha-independent effects of oleoylethanolamide on intestinal transit in mice

2009

Oleoylethanolamide (OEA) is an endogenous lipid produced in the intestine that mediates satiety by activation of peroxisome proliferator-activated receptor alpha (PPARalpha). OEA inhibits gastric emptying and intestinal motility, but the mechanism of action remains to be determined. We investigated whether OEA inhibits intestinal motility by activation of PPARalpha. PPARalpha immunoreactivity was examined in whole mount preparations of mouse gastrointestinal (GI) tract. The effect of OEA on motility was assessed in wildtype, PPARalpha, cannabinoid CB(1) receptor and CB(2) receptor gene-deficient mice and in a model of accelerated GI transit. In addition, the effect of OEA on motility was as…

medicine.medical_specialtyPhysiologymedicine.medical_treatmentTRPV Cation ChannelsMotilityOleic AcidsBiologydigestive systemReceptor Cannabinoid CB2MiceOleoylethanolamidechemistry.chemical_compoundReceptor Cannabinoid CB1Glucagon-Like Peptide 1Internal medicinemedicineAnimalsPPAR alphaReceptorMice KnockoutGastric emptyingEndocrine and Autonomic Systemsdigestive oral and skin physiologyGastroenterologyImmunohistochemistryEndocannabinoid systemEndocrinologyMechanism of actionchemistrylipids (amino acids peptides and proteins)CannabinoidPeroxisome proliferator-activated receptor alphamedicine.symptomGastrointestinal MotilityEndocannabinoids
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