Search results for "Oncology"

SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders

2022

Abstract Background The clinical efficacy of SARS-CoV-2 vaccines according to antibody response in immunosuppressed patients such as hematological patients has not yet been established. Patients and methods A prospective multicenter registry-based cohort study conducted from December 2020 to December 2021 by the Spanish transplant and cell therapy group was used to analyze the relationship of antibody response at 3–6 weeks after full vaccination (2 doses) with breakthrough SARS-CoV-2 infection in 1394 patients with hematological disorders. Results At a median follow-up of 165 days after complete immunization, 37 out of 1394 (2.6%) developed breakthrough SARS-CoV-2 infection at median of 77 …

Innovative technical implementation of the Schumann resonances and its influence on organisms and biological cells

2019

Over the course of time in the digital age, oscillating processes were utilized in various realizations. Life without these became hardly imaginable. Schumann resonances are electromagnetical resonances or eigenfrequencies (radio waves), which originate from the oscillation in a hollow space shell. Their average basic frequency is 7,83Hz. The above-mentioned radio waves emerge from energy discharges such as thunderstorms, lightning or solar wind within the earth's surface and the ionosphere. They exist around the globe. Various scientists have discovered a correlation to our health on the basis of studies and experiments; their absence can result in a variety of disorders from headaches to …

PNR-35CNS HGNET-BCOR - MOLECULAR CHARACTERIZATION AND IDENTIFICATION OF POSSIBLE THERAPEUTIC TARGETS OF A NEW BRAIN TUMOR ENTITY

2016

Novel simple templates for reproducible positioning of skin applicators in brachytherapy.

2016

Purpose : Esteya and Valencia surface applicators are designed to treat skin tumors using brachytherapy. In clinical practice, in order to avoid errors that may affect the treatment outcome, there are two issues that need to be carefully addressed. First, the selected applicator for the treatment should provide adequate margin for the target, and second, the applicator has to be precisely positioned before each treatment fraction. In this work, we describe the development and use of a new acrylic templates named Template La Fe-ITIC. They have been designed specifically to help the clinical user in the selection of the correct applicator, and to assist the medical staff in reproducing the po…

OMICfpp: a fuzzy approach for paired RNA-Seq counts

2019

© The Author(s) 2019.

The evolution, diversity and host associations of rhabdoviruses

2015

Metagenomic studies are leading to the discovery of a hidden diversity of RNA viruses, but new approaches are needed predict the host species these poorly characterised viruses pose a risk to. The rhabdoviruses are a diverse family of RNA viruses that includes important pathogens of humans, animals and plants. We have discovered the sequences of 32 new rhabdoviruses through a combination of our own RNA sequencing of insects and searching public sequence databases. Combining these with previously known sequences we reconstructed the phylogeny of 195 rhabdovirus sequences producing the most in depth analysis of the family to date. In most cases we know nothing about the biology of the viruses…

Human Systems Design: Towards an Integrative Conceptual Framework

2020

International audience; Conceiving artefacts and tools is one of the major key characteristics of the human species. Since the beginning of automation and even more since the spreading of computer science, this activity has become more and more challenging especially through the analysis of the different interaction modes between the artifacts and the human. Nowadays, developing an artifact that must interact with a human is requiring an integrative point of view which must include biological, physical and cybernetical concerns. The current norms aimed at characterizing the quality and the relevance of human machine interface are generally limited to standard interfaces and/or to specific d…

Calibration of mobile manipulators using 2D positional features.

2018

International audience; Robotic manipulators are increasingly being attached to Automatic Ground Vehicles (AGVs) to aid in the efficiency of assembly for manufacturing systems. However, calibrating these mobile manipulators is difficult as the offset between the robotic manipulator and the AGV is often unknown. This paper provides a novel, simple, and low-cost method for calibrating and measuring the performance of mobile manipulators by using data collected from a laser retroreflector that digitally detects the horizontal two-dimensional (2D) position of reflectors on an artifact as well as a navigation system that provides the heading angle and 2D position of the AGV. The method is mathem…

Overview of the Development of Hydraulic Above Knee Prosthesis

2017

This paper presents research and development of hydraulically powered above-knee prosthesis (HAKP) and novel prosthetic foot, in order to enable transfemoral (TF) amputees perform stair ascent and other daily activities in as much as possible natural manner. Functions that need exertion of large forces and moments during locomotion such as walking up stairs and slopes cannot be naturally accomplished by commercially available microprocessor-controlled above-knee (AK) prostheses. Also, such prosthetic devices are expensive and unaffordable for major part of amputee population, so mostly used commercial prostheses are energetically passive devices. Deficiency of passive prosthetic devices is …

Novedades en inmunología del melanoma

2017

Resumen Desde la introduccion de la inmunoterapia el tratamiento del melanoma ha sufrido una revolucion, consiguiendose cifras de supervivencia superiores a las que se alcanzaban con los tratamientos previos. Los farmacos inmunomoduladores disponibles actualmente van dirigidos principalmente frente a las moleculas de superficie CTLA-4 y PD-1, que ejercen un efecto inhibidor sobre la respuesta inmune antitumoral. Se trata de un tratamiento en pleno proceso de expansion, y la investigacion se dirige hacia el descubrimiento de nuevas moleculas, las combinaciones de los farmacos disponibles o la identificacion de biomarcadores que permitan seleccionar a los pacientes idoneos para cada terapia.