Search results for "Ones"
showing 10 items of 7243 documents
Agulló Albuixech, Recaredo y Agulló Calatayud, Víctor. El joc de pilota a través de la prensa valenciana 1790-1909.
2011
Patrimonio cultural para el desarrollo humano desde el Enfoque de Capacidades de Amartya Sen
2017
Este trabajo de investigación tiene por objetivo analizar la relación entre ciudadanía y patrimonio cultural bajo los postulados del Enfoque de Capacidades (EC) promovido principalmente por Amartya Sen y otros autores que se han sumado a este enfoque. El EC nos permite metodológicamente evaluar el estado social de las cosas (nivel de desarrollo humano) desde lo que el sujeto (individual y colectivo) quiere hacer y ser en la vida contando para ello con recursos en forma de bienes culturales del pasado (objeto/elemento patrimonial) que reconoce y le permite funcionamientos relevantes en su vida. En el desarrollo de este trabajo retomamos conceptos que ya hemos formulado y usado en anterio…
Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation and Study of Diabetic Nephropathy with Atrasentan : what …
2019
Albuminuria; Atrasentan; Canagliflozin Albuminuria; Atrasentan; Canagliflozina Albuminúria; Atrasentan; Canagliflozina In April 2019, two major Phase 3 randomized clinical trials were published that assessed primary renal outcomes in diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM). The Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) tested an already available antidiabetic drug, canagliflozin, and the Study of Diabetic Nephropathy with Atrasentan (SONAR) tested a novel molecule, the endothelin-1 receptor blocker atrasentan, both on top of renin-angiotensin system blockade. Both trials demonstrated significant nephroprot…
Effects of an incremental maximal endurance exercise stress-induced cortisol on cognitive performance
2019
Exercise; Cognitive functions; Cortisol Ejercicio físico; Funciones cognitivas; Cortisol Exercici físic; Funcions cognitives; Cortisol Objectives: It can be hypothesized that cognitive performance decreases after fatigue protocol when it coincides with the maximum peak of cortisol. The first aim of this study was to elucidate the effects of a single bout of high intensity exercise on behavioural (i.e., attention and memory) and physiological (i.e., salivary cortisol) responses. The second objective was to evaluate the effect of the performance of the cognitive tasks on cortisol levels. Methods: Thirty-four physically active men (at least 5 days/week of physical activity practice) 38.11 (1.5…
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a …
2022
Invasive mechanical ventilation; COVID-19; Critical care Ventilación mecánica invasiva; COVID-19; Cuidado crítico Ventilació mecànica invasiva; COVID-19; Atenció crítica Background Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods This is a multin…
CT angiography for the assessment of EVAR complications : a pictorial review
2022
Aortic aneurysm; Blood vessel prosthesis implantation; Endovascular procedures Aneurisma aórtico; Implantación de prótesis de vasos sanguíneos; Procedimientos endovasculares Aneurisma aòrtic; Implantació de pròtesis de vasos sanguinis; Procediments endovasculars Endovascular aneurysm repair (EVAR) is a minimally invasive treatment proposed as an alternative to open repair in patients with abdominal aortic aneurysms. EVAR consists in a stent-graft placement within the aorta in order to exclude the aneurysm from arterial circulation and reduce the risk of rupture. Knowledge of the various types of devices is mandatory because some stents/grafts are more frequently associated with complication…
'Fictio libertatis': rilevanza dei 'debita servorum' all'interno della struttura formulare delle 'actiones adiecticiae qualitatis'
1998
Esquema de derivación consistente de prioridades en un marco de consenso
2019
La toma de decisiones impregna la actividad humana. Con frecuencia, la decisión no es simple porque involucra elementos cualitativos, subjetivos, intangibles. En diversos métodos de decisión multi-criterio, los elementos protagonistas de tales procesos son comparados por pares, y tales comparaciones se utilizan para construir una matriz de comparaciones, de cuyo estudio emerge la decisión. En AHP (Analytic Hierarchy Process), por ejemplo, las prioridades se obtienen vía el vector propio de Perron de tales matrices. Para que la decisión sea adecuada, no obstante, las comparaciones deben ser aceptablemente consistentes. Pero cuando se comparan muchos elementos, la consistencia puede flaquear,…
Pyrithione-based ruthenium complexes as inhibitors of aldo-keto reductase 1C enzymes and anticancer agents.
2016
Four ruthenium complexes of clinically used zinc ionophore pyrithione and its oxygen analog 2-hydroxypyridine N-oxide were prepared and evaluated as inhibitors of enzymes of the aldo–keto reductase subfamily 1C (AKR1C). A kinetic study assisted with docking simulations showed a mixed type of inhibition consisting of a fast reversible and a slow irreversible step in the case of both organometallic compounds 1A and 1B. Both compounds also showed a remarkable selectivity towards AKR1C1 and AKR1C3 which are targets for breast cancer drug design. The organoruthenium complex of ligand pyrithione as well as pyrithione itself also displayed toxicity on the hormone-dependent MCF-7 breast cancer cell…
Dans la jungle des milieux cultivés
2009
National audience; Les champs sont des milieux rudes, mais fertiles, pour les mauvaises herbes, qui réussissent parfois à y prospérer. Les dommages sont alors multiples : économiques, environnementaux, sanitaires…