Search results for "Open"
showing 10 items of 3963 documents
Mucopolysaccharidoses and other lysosomal storage diseases.
2013
Mucopolysaccharidosis and other lysosomal storage diseases are rare, chronic, and progressive inherited diseases caused by a deficit of lysosomal enzymes. Patients are affected by a wide variety of symptoms. For some lysosomal storage diseases, effective treatments to arrest disease progression, or slow the pathologic process, and increase patient life expectancy are available or being developed. Timely diagnosis is crucial. Rheumatologists, orthopedics, and neurologists are commonly consulted due to unspecific musculoskeletal signs and symptoms. Pain, stiffness, contractures of joints in absence of clinical signs of inflammation, bone pain or abnormalities, osteopenia, osteonecrosis, secon…
La «communication» de l’art préhistorique: de la pratique didactique à la redécouverte de l’invisible
2009
Les sites préhistoriques peuvent devenir les instruments de la reconnaissance de l’identité d’une communauté par rapport à son territoire. Ce sont les spectateurs du lien existant entre facteurs visibles et invisibles à l’intérieur même des sites. En ce qui concerne les découvertes préhistoriques, on a conscience que le pouvoir de témoigner le plus fort est exprimé principalement par les formes primordiales d’art rupestre. Souvent s’imposent des solutions dans lesquelles la technique est « mise au service » de la préhistoire afin de la rendre accessible au public. Cette accessibilité se réalise à travers la création d’un pôle muséal. Avec les ateliers didactiques consacrés à l’« art rupestr…
Who enjoys listening to sad music and why?
2011
although people generally avoid negative emotional experiences in general, they often enjoy sadness portrayed in music and other arts. The present study investigated what kinds of subjective emotional experiences are induced in listeners by sad music, and whether the tendency to enjoy sad music is associated with particular personality traits. One hundred forty-eight participants listened to 16 music excerpts and rated their emotional responses. As expected, sadness was the most salient emotion experienced in response to sad excerpts. However, other more positive and complex emotions such as nostalgia, peacefulness, and wonder were also evident. Furthermore, two personality traits – Opennes…
Beliefs affecting additional investment intentions of mutual fund clients
2015
In this article, we aim to examine mutual fund investors’ behaviour in decision-making situations and to analyse future investment decisions via a path model approach. Investors were divided into different groups based on the risk and distribution channel used, and the differences in their investment intentions were examined. The study used empirical survey data collected from the clients of a mutual fund company owned by a Finnish banking group. Loyalty to the common banking group dominated the explanation in the whole model. The safety of the investment was important for branch office investors, whereas obtaining a good return was important for internet investors. Ultimately, explanatory …
Atklātā pirmkoda resursu vadības sistēma OpenERP
2016
Maģistra darbā “Atklātā pirmkoda resursu vadības sistēma OpenERP” tiek pētīts, kas ir resursu vadības sistēma (ERP), tiek aplūkotas, kādas ir atšķirības starp patentēto un atklātā pirmkoda ERP sistēmām un izpētīts, ko uzņēmums iegūst, ieviešot ERP risinājumu, un kādi ir iespējamie riski ar kuriem var saskarties uzņēmums pēc ERP risinājuma implementācijas. Tiek pētīts, kāpēc un kādas nesaderības var rasties starp uzņēmumu un ERP programmu, kā tās var mazināt. Darbā tiek pētīta atklātā pirmkoda resursu vadības sistēmas OpenERP funkcionalitāte un tās pielāgošanas iespējas. Autore veica neliela moduļa izstrādi, lai noskaidrotu, kā notiek jauna moduļa izveide. Rezultātā darba autore ir izstrādāj…
Novel Translational Read-through–Inducing Drugs as a Therapeutic Option for Shwachman-Diamond Syndrome
2022
Shwachman-Diamond syndrome (SDS) is one of the most commonly inherited bone marrow failure syndromes (IBMFS). In SDS, bone marrow is hypocellular, with marked neutropenia. Moreover, SDS patients have a high risk of developing myelodysplastic syndrome (MDS), which in turn increases the risk of acute myeloid leukemia (AML) from an early age. Most SDS patients are heterozygous for the c.183-184TA>CT (K62X) SBDS nonsense mutation. Fortunately, a plethora of translational read-through inducing drugs (TRIDs) have been developed and tested for several rare inherited diseases due to nonsense mutations so far. The authors previously demonstrated that ataluren (PTC124) can restore full-length SBDS…
ENABLING LOCAL GOVERNMENTS TO DESIGN AND IMPLEMENT ANTI-CORRUPTION STRATEGIES THROUGH DYNAMIC PERFORMANCE MANAGEMENT AND GOVERNANCE. A CASE-STUDY OF …
2021
Lo scopo principale di questa ricerca è quello di inquadrare le possibili relazioni causali fra corruzione negli approvvigionamenti pubblici e performance delle amministrazioni locali. A tal fine, viene adottato un disegno di ricerca che integra dinamicamente metodi quantitativi e qualitativi in ogni fase del processo di studio. Gli approcci Dynamic Performance Management (DPM) e Governance (DPG), supportati da interviste approfondite non-strutturate, modellazioni formali e simulazioni quantitative, sono qui adottati per analizzare un caso di studio rappresentativo di un piccolo comune italiano in cui si sono verificati alcuni episodi di corruzione nelle attività di approvvigionamento nei p…
Impact of pharmacological and environmental manipulations on neuronal structural plasticity and dynamics
2017
El sistema nervioso de vertebrados es uno de los más estudiados, aunque peor comprendidos, del organismo de mamíferos. Desde que Ramón y Cajal postuló su teoría celular de este sistema (Ramón y Cajal 1909), la neurona se ha postulado como su unidad funcional. Sin embargo, durante las últimas décadas se ha revolucionado la visión que se tenía de éste. Una de las percepciones más asentadas era que, tras el desarrollo embrionario, el sistema nervioso se mantenía inmutable. Sin embargo, ahora sabemos que diferentes formas de plasticidad gobiernan su adaptación, que son necesarias para importantes procesos del día a día, tales como el aprendizaje y la memoria (Smythies 2002; Berlucchi and Buchte…
Experimental on-demand recovery of entanglement by local operations within non-Markovian dynamics
2015
In many applications entanglement must be distributed through noisy communication channels that unavoidably degrade it. Entanglement cannot be generated by local operations and classical communication (LOCC), implying that once it has been distributed it is not possible to recreate it by LOCC. Recovery of entanglement by purely local control is however not forbidden in the presence of non-Markovian dynamics, and here we demonstrate in two all-optical experiments that such entanglement restoration can even be achieved on-demand. First, we implement an open-loop control scheme based on a purely local operation, without acquiring any information on the environment; then, we use a closed-loop s…
Quantum Non-Markovian Piecewise Dynamics from Collision Models
2017
Recently, a large class of quantum non-Markovian piecewise dynamics for an open quantum system obeying closed evolution equations has been introduced [B. Vacchini, Phys. Rev. Lett. 117, 230401 (2016)]. These dynamics have been defined in terms of a waiting-time distribution between quantum jumps, along with quantum maps describing the effect of jumps and the system's evolution between them. Here, we present a quantum collision model with memory, whose reduced dynamics in the continuous-time limit reproduces the above class of non-Markovian piecewise dynamics, thus providing an explicit microscopic realization.