Search results for "Opera"

showing 10 items of 8665 documents

Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

Graphical abstract

ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
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Intraoperative transfusion practices in Europe

2016

PubMed: 26787795

AUSTRIAN BENCHMARKMaleBlood transfusionmedicine.medical_treatment610 Medizinanaemia anesthesia blood transfusion surgery transfusion trigger030204 cardiovascular system & hematologyGUIDELINESsurgeryCohort Studies0302 clinical medicine030202 anesthesiologyMedicine and Health SciencesMedicineProspective StudiesProspective cohort studyddc:610Research Support Non-U.S. Gov'tMiddle AgedHospitalsEuropeFemaleAllogeneic transfusionCohort studymedicine.medical_specialtyTransfusion rateObservational Studyanesthesiablood transfusionELECTIVE SURGERYClinical Practice03 medical and health sciencesJournal Articleanaemia ; anesthesia ; blood transfusion ; surgery ; transfusion triggerHumansBlood TransfusionElective surgeryCHLC ANSIntensive care medicineanaemiatransfusion triggerIntraoperative Carebusiness.industryPREOPERATIVE ANEMIAPATIENT BLOOD MANAGEMENTClinical trialAnesthesiology and Pain MedicineEmergency medicinebusinessPacked red blood cellsREQUIREMENTSBritish journal of anaesthesia
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Small bowel obstruction after laparoscopic gastrectomy: An atypical clinical presentation. Report of a case

2020

Abstract Introduction Postoperative adhesions represent the most common cause of acute small bowel obstruction (80%) and are usually a consequence of abdomino-pelvic surgery performed with open technique. Presentation of case A 45-year-old black man arrived at the emergency room with abdominal pain and distension three months after laparoscopic distal gastrectomy with Roux-en-Y anastomosis performed for benign pyloric stenosis. CT abdominal scan revealed some air-fluid levels in the center of the abdomen with distension of proximal jejunal loops caused by intestinal adhesions. Laparoscopic adhesiolysis was performed to restore the intestinal transit. Discussion The formation of adhesions is…

Abdominal painmedicine.medical_specialtyAdhesiolysismedicine.medical_treatmentCase ReportAnastomosisDistensionPyloric stenosis03 medical and health sciences0302 clinical medicineLaparotomymedicineLaparoscopyPostoperative adhesionsmedicine.diagnostic_testbusiness.industrySmall bowel obstructionmedicine.diseaseSurgeryBowel obstructionmedicine.anatomical_structure030220 oncology & carcinogenesisLaparoscopic gastrectomyAbdomenLaparoscopy030211 gastroenterology & hepatologySurgerymedicine.symptombusinessInternational Journal of Surgery Case Reports
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Microbiological characterization and effect of resin composites in cervical lesions

2017

Background Non carious cervical lesions associated to muscle hyperfunctions are increasing. Microhybrid resin composites are used to restore cervical abfractions. The purpose of this study was to investigate if resin composites modify tooth plaque, inducing an increment of cariogenic microflora and evaluate their effect, in vivo and in vitro, against S. mutans. Material and Methods Eight abfractions were restored with two microhybrid resin composites (Venus, Heraeus-Kulzer® and Esthet-X, Dentsply®), after gnatological therapy, in three patients with muscle hyperfunctions. For each abfraction three samples of plaque were taken from the cervical perimeter: before the restoration, one week and…

AbfractionAbfraction; Class V; Composite; Restoration; S. mutans; Dentistry (all)business.industryChemistryResearchPlaque compositionResin compositeDentistryPlaque growthCompositeOdontologíamedicine.diseaseAbfractionCiencias de la saludClass VOperative Dentistry and EndodonticsTooth plaqueIn vivoRestorationmedicineDentistry (all):CIENCIAS MÃ DICAS [UNESCO]businessGeneral DentistryS. mutans
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Shared Leadership Regulates Operational Team Performance in the Presence of Extreme Decisional Consensus/Conflict: Evidences from Business Process Re…

2019

This study focuses on decision-making within operational teams. Grounding our argumentation on group decision-making literature, we argue that adverse behavior patterns may affect the way in which consensus is achieved within the team, and that team performance has an inverted U-shaped relationship with the level of consensus. Then, by relying on leadership literature, we pose the hypothesis that the level of shared leadership inside the group moderates this U-shaped relationship. To empirically test our literature-based argumentation, we use longitudinal data collected in the years 2014 and 2015 from business process reengineering projects, each lasting three months, conducted by 141 maste…

Abilene Paradox Performance Business Process Reengineering Group Decision-Making Groupthink Operational Team Shared-Leadership
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The Intention-to-Treat Effect of Bridging Treatments in the Setting of Milan Criteria–In Patients Waiting for Liver Transplantation

2019

In patients with hepatocellular carcinoma (HCC) meeting the Milan criteria (MC), the benefit of locoregional therapies (LRTs) in the context of liver transplantation (LT) is still debated. Initial biases in the selection between treated and untreated patients have yielded conflicting reported results. The study aimed to identify, using a competing risk analysis, risk factors for HCC-dependent LT failure, defined as pretransplant tumor-related delisting or posttransplant recurrence. The study was registered at www.clinicaltrials.gov (identification number NCT03723304). In order to offset the initial limitations of the investigated population, an inverse probability of treatment weighting (IP…

Ablation TechniquesGraft RejectionMaleTime FactorsHepatocellular carcinomaIMPACTmedicine.medical_treatmentSettore MED/18 - CHIRURGIA GENERALEintent to treatLOCOREGIONAL THERAPYKaplan-Meier Estimate030230 surgeryLiver transplantationLIVER TRANSPLANTATION HEPATOCELLULAR CARCINOMA RISK FACTORS OUTCOME PROGNOSTIC SCOREGastroenterologyLiver disease0302 clinical medicineRisk FactorsHEPATOCELLULAR-CARCINOMAHepatocellular carcinoma liver transplantation risk factors intent to treat prognostic score waiting listeducation.field_of_studyLiver NeoplasmsAge FactorsDEATHwaiting listMiddle AgedCANCERprognostic scoreIntention to Treat AnalysisTIMETreatment OutcomeHepatocellular carcinomaDisease ProgressionSURVIVAL030211 gastroenterology & hepatologyFemalemedicine.symptommedicine.medical_specialtyCarcinoma HepatocellularWaiting ListsALPHA-FETOPROTEINPopulationMilan criteriamRECISTRisk AssessmentLesionalpha-fetoprotein03 medical and health sciencesSex FactorsInternal medicinePreoperative CaremedicineHumansHepatology; gastroenterology; hepatocelluar cancer; locoregional therapieseducationRECURRENCEOUTCOMETransplantationLiver transplantationIntention-to-treat analysisHepatologybusiness.industryHEPATOCELLULAR-CARCINOMA; ALPHA-FETOPROTEIN; LOCOREGIONAL THERAPY; RECURRENCE; CANCER; MODEL; TIME; SURVIVAL; IMPACT; DEATHlocoregional therapymedicine.diseaseSettore MED/18Liver TransplantationMODELhepatocellular cancerTumor progressionSurgerybusinessFollow-Up Studies
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Endovenous ablation of refluxing saphenous and perforating veins.

2017

Abstract. Since the end of the nineties endovenous thermal ablation and more recently non-thermal, non-tumescent techniques have been developed and improved. Until now, because of their favourable side effect profile in conjunction to sustained efficacy, in many countries they already replaced high ligation and stripping in the treatment of refluxing saphenous veins as well as for treatment of perforators and selected tributaries. Now, studies and comparative trials are available with long-term follow-ups for most of the techniques, providing valid data on occlusion and reflux rates, side effect profiles, and health related quality of life.

Ablation Techniquesmedicine.medical_specialtyTime FactorsSide effectRadiofrequency ablationThermal ablation030204 cardiovascular system & hematologylaw.invention030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicinePostoperative ComplicationslawRisk FactorsOcclusionMedicineHumansSaphenous VeinHealth related quality of lifebusiness.industryEndovenous ablationComparative trialSurgerySteamTreatment OutcomeVenous InsufficiencyCatheter AblationLaser TherapyPerforating veinsCardiology and Cardiovascular MedicinebusinessVASA. Zeitschrift fur Gefasskrankheiten
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A heuristic algorithm for project scheduling with splitting allowed

1996

In this article, we analyze the precedence diagramming method, the only published algorithm for time-only project scheduling with activity splitting allowed. The criteria used in this method (forward and backward pass computations) for deciding when an activity has to be interrupted are shown to be invalid in some situations. We look into the causes of these failures and propose new formulae that always provide feasible solutions. The new algorithm has been tested on 240 randomly generated problems ranging up to 600 activities and 7,200 precedence relationships, resulting in an average deviation from optima of less than 1 percent.

Absolute deviationMathematical optimizationControl and OptimizationPrecedence diagram methodArtificial IntelligenceComputer Networks and CommunicationsComputer scienceComputationRangingManagement Science and Operations ResearchAlgorithmSoftwareInformation SystemsJournal of Heuristics
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Investigation of water sorption and aluminum releases from high viscosity and resin modified glass ionomer.

2019

Background High viscosity glass ionomer cement (HVGIC) and resin-modified glass ionomer cement (RMGIC) have recently been clinically preferred thanks to their numerous advantages. However, initial moisture contamination has a negative effect on the mechanical and physical properties of these cements. The aim of this study was in vitro of HVGICs and RMGICs, with and without surface protection, on water sorption, solubility and release of aluminum. Material and Methods In this study, as HVGICs; Equia Forte, IonoStar Plus, Riva Self Cure; as RMCIS, Ionolux and Riva Light Cure; and as control, Z250 universal composite was used. Equia coat, Voco varnish and Riva coat were chosen as surface prote…

Absorption of waterMaterials scienceMoistureResearchVarnishComposite numberGlass ionomer cementchemistry.chemical_element030206 dentistry:CIENCIAS MÉDICAS [UNESCO]Operative Dentistry and Endodontics03 medical and health sciences0302 clinical medicinechemistryAluminiumvisual_artUNESCO::CIENCIAS MÉDICASvisual_art.visual_art_mediumSolubilityComposite materialGraphite furnace atomic absorptionGeneral Dentistry030217 neurology & neurosurgeryJournal of clinical and experimental dentistry
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The vibrational levels of methane obtained from analyses of high-resolution spectra

2006

International audience; Methane and its tetrahedral isotopologues are spherical-top molecules whose high-resolution rovibrational spectra can only be analyzed in detail, thanks to sophisticated symmetry-adapted tensorial models. However, the effective Hamiltonian parameters of such models do not give direct access to the positions of the vibrational sublevels. In this paper, we present a calculation of the vibrational level positions for 12CH4, 13CH4, 12CD4 and 13CD4 performed using the effective Hamiltonian parameters obtained through recent analyses. We also include the results of a re-analysis of the octad system of 12CH4 performed with a higher order of the development which slightly im…

Absorption spectroscopy01 natural sciencesSpectral lineMethanesymbols.namesakechemistry.chemical_compoundvibrational levels and sublevels0103 physical sciencesIsotopologuepolyads010303 astronomy & astrophysicsSpectroscopyPhysics[PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph]Radiation010304 chemical physicsmethanepotential surfaceRotational–vibrational spectroscopyAtomic and Molecular Physics and OpticsMathematical Operatorschemistry[ PHYS.PHYS.PHYS-AO-PH ] Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph]TetrahedronsymbolsAtomic physicsHamiltonian (quantum mechanics)tensorial formalism
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