Search results for "Opera"
showing 10 items of 8665 documents
Theoretical study of selective H3 receptor antagonists of histamine
1993
Abstract The conformations and charge distributions of three selective H3 receptor antagonists of histamine were determined using the MNDO approach. The results suggest that the conformational flexibilities of betahistine, N α-(2-phenylacetyl)histamine and thioperamide are different; however, the low-energy conformations of these compounds show closely related spatial orderings. The MNDO calculations predict a significant population of the N1H form in the imidazole systems of N α-(2-phenylacetyl)histamine and thioperamide. Our results indicate that the conformational behaviour of H3 antagonists is closely similar to that reported for H2 antagonists of histamine. These results emphasize the …
The joint emergence of group competition and within-group cooperation
2015
Abstract Between-group conflict and within-group cooperation can be seen as two sides of the same coin, coevolving in a group-structured population. There is strong support for between-group competition facilitating the evolution of human cooperative tendencies, yet our understanding of how competition arises is less clear. We show that groups of randomly assembled individuals spontaneously engage in costly group competition, and that decisions promoting between-group conflict are associated with high levels of within-group cooperation. Remarkably, when groups were given the possibility to compete against other groups, net earnings for individuals were higher than when groups were not allow…
Family business entrepreneurs' influence on entrepreneurship education and training : a discussion paper
2009
Entrepreneur education and training are the key concepts for the success and wel-fare of the European societies. In this, the most important actors are the local and national family business entrepreneurs and their enterprises. The challenge for them is to become global and to build international business and social networks with their European counterparts as well as to learn to be motivated in coopera-tion with educational establishments. This study focuses on the online learning program of Global Entrepreneurship developed with the support of family busi-ness entrepreneurs as mentors. The students act as business assistants to the entre-preneurs. The study offers entrepreneurs an excitin…
Yield and efficiency of the financial organizations of social economy in Spain
2009
Las entidades financieras de la Economía Social en España (cajas de ahorros, cooperativas de crédito y secciones de crédito de cooperativas), a la vez que mantienen su carácter social diferenciador, necesitan mejorar sus niveles de eficiencia. El objetivo principal es realizar un análisis comparativo de la rentabilidad y la eficiencia de estas entidades, atendiendo a diversos indicadores, durante el período 2002-2007. La metodología ha consistido en la realización de un estudio empírico basado en el tratamiento estadístico de sus estados contables, a través de las estadísticas oficiales del Banco de España y los resultados obtenidos de un trabajo de campo mediante cuestionario. El análisis …
Material de pràctiques de Matemàtiques II (2013/2014)
2014
Exercicis resolts i proposats i apunts de modelització de problemes de programació matemàtica per a l'assignatura Matemàtiques II dins dels estudis de grau en Economia, en administració i direcció d'empreses i en finances i comptabilitat Solved and proposed exercices and notes on modelling problems of mathematical programming of the subject "Matemàtiques II", in the studies of degree in Economics, degree in business administration and degree in finance and accounting Aquest material ha rebut un dels incentius de la convocatòria 2012 per a la qualitat en l’elaboració de materials docents del Servei de Política Lingüística de la Universitat de València, servei que també ha revisat lingüística…
Development of a New Clusterization Method for the GEM-TPC Detector
2022
The Facility for Antiproton and Ion Research FAIR, in Darmstadt Germany, will be one of the largest accelerator laboratories worldwide. The Superconducting FRagment Separator (Super-FRS)* is one of its main components. The Super-FRS can produce, separate and deliver high-energy radioactive beams with intensities up to 1e11 ions/s, covering projectiles from protons up to uranium and it can be used as an independent experimental device. The Gas Electron Multiplier-based Time Projection Chambers (GEM-TPC) in twin configuration is a newly developed beam tracking detector capable of providing spatial resolution of less than 1 mm with a tracking efficiency close to 100% at 1 MHz counting rate. Th…
Food Security Is None Of Your Business? Food Supply Chain Management In Support Of A Sustainable Food System
2017
Food security is the principal outcome of any given food system and it can be defined in terms of a sustainable food system where the core goal is to feed everyone sustainably, equitably and healthily. A sustainable food system addresses needs for availability, affordability and accessibility, is diverse, ecologically-sound and resilient, and builds the capabilities and skills necessary for future generations. This paper identifies the essential elements of food supply chain management in support of a sustainable food system, which ultimately enhances food security. The existing food supply chain and food system literature is synthesized in order to study the correspondence between public i…
Acetaldehyde as a drug of abuse: Involvement of endocannabinoid- and dopamine neurotransmission
2014
Acetaldehyde (ACD), the first metabolite of ethanol, directly enhances dopamine neurotransmission (1) and has rewarding and motivational properties in paradigms tailored for studying addictive-like behaviours (2, 3). The endocannabinoid system affects distinct drug-related behaviours, since it may in turn fine-tune dopamine cell activity (4, 5). In light of this, the present study aimed at investigating the effects of a direct manipulation of the DAergic synapse, and the contribution of the endocannabinoid system on oral ACD self-administration in rats. ACD drinking-behaviour was evaluated in an operant paradigm consisting of acquisition and maintenance; extinction; deprivation and relapse;…
The LANN technique to reduce postoperative functional morbidity in laparoscopic radical pelvic surgery
2005
BACKGROUND: We investigated the feasibility and advantages of introducing Laparoscopic Neuro-Navigation (LANN) into the field of laparoscopic gynecologic radical pelvic surgery. STUDY DESIGN: In a prospective pilot study, 261 consecutive patients underwent laparoscopic radical pelvic surgery for cervical cancer or deep infiltrating endometriosis of the parametria. During the procedure, dissection and electrostimulation, and consequently, sparing of the pelvic parasympathetic nerves by transection of the parametria, were performed. Postoperative bladder dysfunction was documented. RESULTS: Laparoscopic dissection and electrostimulation of the pelvic splanchnic nerves were feasible in all pat…
Endovascular treatment for chronic cerebrospinal venous insufficiency: is the procedure safe?
2010
Objectives The aim of this report is to assess the safety of endovascular treatment for chronic cerebrospinal venous insufficiency (CCSVI). Although balloon angioplasty and stenting seem to be safe procedures, there are currently no data on the treatment of a large group of patients with this vascular pathology. Methods A total of 564 endovascular procedures (balloon angioplasty or, if this procedure failed, stenting) were performed during 344 interventions in 331 CCSVI patients with associated multiple sclerosis. Results Balloon angioplasty alone was performed in 192 cases (55.8%), whereas the stenting of at least one vein was required in the remaining 152 cases (44.2%). There were no majo…