Search results for "Opsoclonus."
showing 6 items of 6 documents
Immunoproteomic studies on paediatric opsoclonus-myoclonus associated with neuroblastoma
2016
We aimed to identify new cell-membrane antigens implicated in opsoclonus-myoclonus with neuroblastoma. The sera of 3 out of 14 patients showed IgG electron-microscopy immunogold reactivity on SH-SY5Y neuroblastoma cells. Immunoprecipitation experiments using rat brain synaptosomes and SH-SY5Y cells led to the identification of: (1) thirty-one nuclear/cytoplasmic proteins (including antigens HuB, HuC); (2) seven neuronal membrane proteins, including the Shaw-potassium channel Kv3.3 (KCNC3), whose genetic disruption in mice causes ataxia and generalized muscle twitching. Although cell-based assays did not demonstrate direct antigenicity, our findings point to Shaw-related subfamily of the pot…
Estudio de anticuerpos frente antígenos de membrana neuronal en síndromes neurológicos con hiperexcitabilidad motora
2017
El Síndrome Opsoclonus-Mioclonus (SOM) y la Neuromiotonía (NMT) son enfermedades neurológicas, caracterizadas por movimientos involuntarios, que en ocasiones presentan asociaciones paraneoplásicas(neuroblastoma en niños y timoma, respectivamente). Estas enfermedades se han relacionado con procesos autoinmunes. A pesar los esfuerzos de numerosos grupos de investigación por determinar los antígenos responsables de estas enfermedades, todavía son desconocidos. Empleando técnicas de inmunoprecipitación con diferentes sustratos y expresando las proteínas identificadas en células no neurales, tratamos de identificar en estas enfermedades nuevos antígenos de superficie, accesibles para los anticue…
Opsoclonus-myoclonus syndrome attributable to West Nile encephalitis: a case report
2014
Introduction Opsoclonus-myoclonus syndrome is a very rare neurological disorder associated with some viral infections and exceptionally with the West Nile virus. Case presentation A 57-year-old Caucasian woman presented with fever, dizziness, balance difficulties, vomiting, dancing eye, altered speech, tremor, generalized myoclonus and failure to rise or stand. Our objective is to describe a patient with West Nile infection, which was identified both in her serum and cerebrospinal fluid and was associated with encephalitis and opsoclonus-myoclonus-ataxia syndrome. Conclusions Opsoclonus-myoclonus-ataxia syndrome continued for 4 weeks after onset, when she died. There was no evidence for any…
Ocular Motor Paroxysmal Events in Neonates and Infants: A Review of the Literature
2021
Abstract Background Ocular paroxysmal events can accompany a variety of neurological disorders. Particularly in infants, ocular paroxysmal events often represent a diagnostic challenge. Distinguishing between epileptic and nonepileptic events or between physiological and pathologic paroxysmal events can be challenging at this age because the clinical evaluation and physical examination are often limited. Continuous polygraphic video-electroencephalography (EEG) monitoring can be helpful in these situations. Methods We review ocular paroxysmal events in newborns and infants. The aim is to improve clinical recognition of ocular paroxysmal events and provide a guide to further management. Usin…
Genetic features of neuroblastic tumors associated with opsoclonus-myoclonus syndrome opens up the possibility for detection in peripheral blood
2016
Opsoclonus–myoclonus syndrome (OMS) is a rare paraneoplastic, postinfectious, or parainfectious or idiopathic acute neurological syndrome in children and adults. OMS is characterized by involuntary...