Search results for "Opus"

Voltage dependence of L-arginine transport by hCAT-2A and hCAT-2B expressed in oocytes from Xenopus laevis.

2000

Membrane potential and currents were investigated with the two-electrode voltage-clamp technique in Xenopus laevisoocytes expressing hCAT-2A or hCAT-2B, the splice variants of the human cationic amino acid transporter hCAT-2. Both hCAT-2A- and hCAT-2B-expressing oocytes exhibited a negative extracellularl-arginine concentration ([l-Arg]o)-sensitive membrane potential, additive to the K+diffusion potential, when cells were incubated in Leibovitz medium (containing 1.45 mM l-Arg and 0.25 mM l-lysine). The two carrier proteins produced inward and outward currents, which were dependent on the l-Arg gradient and membrane potential. Ion substitution experiments showed that the hCAT-induced curren…

Arginine-rich peptides are blockers of VR-1 channels with analgesic activity

2000

Vanilloid receptors (VRs) play a fundamental role in the transduction of peripheral tissue injury and/or inflammation responses. Molecules that antagonize VR channel activity may act as selective and potent analgesics. We report that synthetic arginine-rich hexapeptides block heterologously expressed VR-1 channels with submicromolar efficacy in a weak voltage-dependent manner, consistent with a binding site located near/at the entryway of the aqueous pore. Dynorphins, natural arginine-rich peptides, also blocked VR-1 activity with micromolar affinity. Notably, synthetic and natural arginine-rich peptides attenuated the ocular irritation produced by topical capsaicin application onto the eye…

Notes per a un exemplar de La conquesta de València (València, Diego de Gumiel, 1515)

2008

En aquest treball s’ofereix una descripció de l’exemplar de l’Aureum opus regalium privilegiorum civitatis et Regni Valentiae cum historia cristianissimi Regis Iacobi ipsius primi conquistatoris conservat a la Casa del Libro (San Juan, Puerto Rico), una de les darreres aventures editorials de l’impressor Diego de Gumiel (30 d’octubre de 1515). 

Un análisis bibliométrico en el área de la Medicina: colaboración científica entre Brasil y España (2002-2011)

2016

[EN]: This study analyzes the development of Spanish-Brazilian collaborative scientific production in the field of medical research between 2002 and 2011, identifying the most productive institutions, the proportion of researchers from each country and bi-lateral collaborative networks. Data were gathered from the Scopus database, which offers broad, international coverage of multidisciplinary research. A study sample of 1,121 original scientific articles signed by 13,906 researchers were retrieved, on the basis of which the annual growth rate of Spanish-Brazilian medical research was calculated. A remarkably high degree of internationalization was found, with 121 countries participating in…

Binge Drinking: The Top 100 Cited Papers

2021

We conducted a review to analyze the 100 most-cited studies on binge drinking (BD) in the Web of Science (WoS) database to determine their current status and the aspects that require further attention. We carried out a retrospective bibliometric analysis in January 2021. The year of publication, authors, design, subject, journal, institution and lead author’s country, as well as the definition of BD, were extracted from the articles. The data on the country, year, thematic category of the journals and their rank were obtained from the Institute for Scientific Information (ISI) Journal Citation Reports 2020. The number of citations was collected from the WoS, and the h index was collected fr…

V.-Beneyto

2010

Worldwide research output trends on drinking and driving from 1956 to 2015.

2020

This study seeks to analyze worldwide research activity on drinking and driving of macro-actors (countries and research fields) and meso-actors (institutions, journals, articles, co-substance(s) studied) during the last 6 decades (between 1956 and 2015). Web of Science and Elsevier Scopus were searched using terms referred to drinking and driving, including terms related to vehicles and way spaces. Overlapping was excluded and absence of false positives was confirmed. Articles on alcohol with/without other psychoactive substances were assessed quantitatively (bibliometric measures). Well identified by All Science Journal Classification system (ASJC) (Elsevier Scopus), an increase in the num…

Analysis of Production, Impact, and Scientific Collaboration on Difficult Airway Through the Web of Science and Scopus (1981-2013).

2017

Bibliometrics, the statistical analysis of written publications, is an increasingly popular approach to the assessment of scientific activity. Bibliometrics allows researchers to assess the impact of a field, or research area, and has been used to make decisions regarding research funding. Through bibliometric analysis, we hypothesized that a bibliometric analysis of difficult airway research would demonstrate a growth in authors and articles over time.Using the Web of Science (WoS) and Scopus databases, we conducted a search of published manuscripts on the difficult airway from January 1981 to December 2013. After removal of duplicates, we identified 2412 articles. We then analyzed the art…

The shell matrix of the european thorny oyster, Spondylus gaederopus: microstructural and molecular characterization.

2020

17 pages; International audience; Molluscs, the largest marine phylum, display extraordinary shell diversity and sophisticated biomineral architectures. However, mineral-associated biomolecules involved in biomineralization are still poorly characterised.We report the first comprehensive structural and biomolecular study of Spondylus gaederopus, a pectinoid bivalve with a peculiar shell texture. Used since prehistoric times, this is the best-known shell of Europe’s cultural heritage. We find that Spondylus microstructure is very poor in mineral-bound organics, which are mostly intercrystalline and concentrated at the interface between structural layers.Using high-resolution liquid chromatog…

A Wnt-specific astacin proteinase controls head formation inHydra

2020

AbstractTheHydrahead organizer acts as a signaling center that initiates and maintains the primary body axis in steady state polyps and during budding or regeneration. Wnt/beta-Catenin signaling functions as a primary cue controlling this process, but how Wnt ligand activity is locally restricted at the protein level is poorly understood.Here we report the identification of an astacin family proteinase as a Wnt processing factor.Hydraastacin-7 (HAS-7) is expressed from gland cells as an apical-distal gradient in the body column, peaking close beneath the tentacle zone.HAS-7siRNA knockdown abrogates HyWnt3 proteolysis in the head tissue and induces a robust double axis phenotype, which is re…