Search results for "Orexin"
showing 10 items of 82 documents
Updating neutrino magnetic moment constraints
2016
20 pages.- 4 figures.- Addendum on the limit from the Borexino data
If sterile neutrinos exist, how can one determine the total solar neutrino fluxes?
2002
The 8B solar neutrino flux inferred from a global analysis of solar neutrino experiments is within 11% (1 sigma) of the predicted standard solar model value if only active neutrinos exist, but could be as large as 1.7 times the standard prediction if sterile neutrinos exist. We show that the total 8B neutrino flux (active plus sterile neutrinos) can be determined experimentally to about 10% (1 sigma) by combining charged current measurements made with the KamLAND reactor experiment and with the SNO CC solar neutrino experiment, provided the LMA neutrino oscillation solution is correct and the simulated performance of KamLAND is valid. Including also SNO NC data, the sterile component of the…
Measuring the14C content in liquid scintillators
2016
We are going to perform a series of measurements where the 14C/12 C ratio will be measured from several liquid scintillator samples with a dedicated setup. The setup is designed with the aim of measuring ratios smaller than 10-18. Measurements take place in two underground laboratories: in the Baksan Neutrino Observatory, Russia and in the Pyhasalmi mine, Finland. In Baksan the measurements started in 2015 and in Pyhasalmi they start in the beginning of 2015. In order to fully understand the operation of the setup and its background contributions a development of simulation packages has also been started. Low-energy neutrino detection with a liquid scintillator requires that the intrinsic 1…
Low-energy (anti)neutrino physics with Borexino: Neutrinos from the primary proton-proton fusion process in the Sun
2014
The Sun is fueled by a series of nuclear reactions that produce the energy that makes it shine. The primary reaction is the fusion of two protons into a deuteron, a positron and a neutrino. These neutrinos constitute the vast majority of neutrinos reaching Earth, providing us with key information about what goes on at the core of our star. Several experiments have now confirmed the observation of neutrino oscillations by detecting neutrinos from secondary nuclear processes in the Sun; this is the first direct spectral measurement of the neutrinos from the keystone proton-proton fusion. This observation is a crucial step towards the completion of the spectroscopy of pp-chain neutrinos, as we…
Hypothalamus-olfactory system crosstalk: orexin a immunostaining in mice
2012
It is well known that olfaction influences food intake, and conversely, that an individual’s nutritional status modulates olfactory sensitivity. However, what is still poorly understood is the neuronal correlate of this relationship, as well as the connections between the olfactory bulb and the hypothalamus. The goal of this report is to analyze the relationship between the olfactory bulb and hypothalamus, focusing on orexin A immunostaining, a hypothalamic neuropeptide that is thought to play a role in states of sleep/wakefulness. Interestingly, orexin A has also been described as a food intake stimulator. Such an effect may be due in part to the stimulation of the olfactory bulbar pathway…
Azulene as a biphenyl mimetic in orexin/hypocretin receptor agonists
2023
Azulene is a rare ring structure in drugs, and we investigated whether it could be used as a biphenyl mimetic in known orexin receptor agonist Nag 26, which is binding to both orexin receptors OX1 and OX2 with preference towards OX2. The most potent azulene-based compound was identified as an OX1 orexin receptor agonist (pEC50 = 5.79 +/- 0.07, maximum response = 81 +/- 8% (s.e.m. of five independent experiments) of the maximum response to orexin-A in Ca2+ elevation assay). However, the azulene ring and the biphenyl scaffold are not identical in their spatial shape and electron distribution, and their derivatives may adopt different binding modes in the binding site. Peer reviewed
Dual orexin receptor blocker suvorexant attenuates hypercapnic ventilatory augmentation in mice
2022
Suvorexant (Belsomra(R)), a dual orexin receptor antagonist widely used in the treatment of insomnia, inhibits the arousal system in the brain. However, the drug’s ventilatory effects have not been fully explored. This study aims to investigate the expression of orexin receptors in respiratory neurons and the effects of suvorexant on ventilation. Immunohistology of brainstem orexin receptor OX2R expression was performed in adult mice (n = 4) in (1) rostral ventral respiratory group (rVRG) neurons projecting to the phrenic nucleus (PhN) retrogradely labeled by Fluoro-Gold (FG) tracer, (2) neurons immunoreactive for paired like homeobox 2b (Phox2b) in the parafacial respiratory group/retrotra…
A high precision calorimeter for hunting the sterile neutrino in the SOX experiment
2019
Abstract A thermal calorimetric apparatus was designed, built and calibrated for measuring the activity of the artificial 144 Ce —144 Pr antineutrino source. This measurement will be performed at the Laboratori Nazionali del Gran Sasso in Italy, just before the source insertion in the tunnel under the Borexino detector and a precision better than 1% is required for a disappearance technique measurement in the SOX (Short distance neutrino Oscillation with BoreXino) project. In this work the apparatus is described and the most important results from the calibration measurements are shown, where the final precision of few per thousand is demonstrated.
Absence of a day-night asymmetry in the7Be solar neutrino rate in Borexino
2012
We report on a search for the day-night asymmetry of the Be-7 solar neutrino rate measured by Borexino at the Laboratori Nazionali del Gran Sasso (LNGS), Italy. The measured value, Adn=0.001 +- 0.012 (stat) +- 0.007 (syst), shows the absence of a significant asymmetry. This result alone rejects the so-called LOW solution at more than 8.5 sigma. Combined with the other solar neutrino data, it isolates the Large Mixing Angle (LMA) -- MSW solution at DeltaChi2 > 190 without relying on the assumption of CPT symmetry in the neutrino sector. We also show that including the day-night asymmetry, data from Borexino alone restricts the MSW neutrino oscillations to the LMA solution at 90% confidence l…
A test of electric charge conservation with Borexino
2015
Borexino is a liquid scintillation detector located deep underground at the Laboratori Nazionali del Gran Sasso (LNGS, Italy). Thanks to the unmatched radio-purity of the scintillator, and to the well understood detector response at low energy, a new limit on the stability of the electron for decay into a neutrino and a single mono-energetic photon was obtained. This new bound, tau > 6.6 10**28 yr at 90 % C.L., is two orders of magnitude better than the previous limit.